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Links from GEO DataSets

Items: 18

1.
Full record GDS3092

Endometriosis

Analysis of ectopic endometrial tissues implanted in the peritoneal cavity of 11 subjects. The growth of endometrial tissue outside of the uterus is called endometriosis. Results provide insight into the molecular pathology of endometriosis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 11 individual sets
Platform:
GPL2895
Series:
GSE5108
22 Samples
Download data
DataSet
Accession:
GDS3092
ID:
3092
2.

Whole human genome DNA microarray analysis of gene expression in ectopic vs. eutopic endometrium

(Submitter supplied) Brief description of the experiment: The objective of this experiment was to use DNA microarrays to identify differentially expressed genes in eutopic uterine endometrium compared to ectopic endometrium. 174 of the 53,000 genes on the whole human DNA microarrays were changed by 5-fold or greater in ectopic vs. eutopic endometrium. Families of genes that were differentially expressed include immune system and inflammatory pathway genes, genes whose cognate proteins code for cell adhesion, junctional proteins, the extracellular matrix and its remodeling, and cytoskeletal proteins, and ligands, receptors, and components of specific signal transduction pathways. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3092
Platform:
GPL2895
22 Samples
Download data
Series
Accession:
GSE5108
ID:
200005108
3.

Differentially expressed genes in HEECs of eutopic endometrium of patients with endometriosis compared with control

(Submitter supplied) The pathogenesis of endometriosis may result from aberrant angiogenesis that occurs in eutopic endometrium with retrograde menstruation. The difference in gene expression profile between human endometrial endothelial cells (HEECs) from eutopic endometria of patients with and without endometriosis would be determinant that affects the occurrence of endometriosis. To explore this kind of difference, we performed in vitro culture and identified their endothelial origin, as well as observed growth features of HEECs from the two different origins. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3060
Platform:
GPL570
10 Samples
Download data: CEL
Series
Accession:
GSE7846
ID:
200007846
4.
Full record GDS3060

Endometriosis: endometrial endothelial cells

Analysis of cultured endometrial endothelial cells derived from the eutopic endometria of patients with endometriosis. Results provide insight into the role of aberrant angiogenesis in the pathogenesis of endometriosis.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE7846
10 Samples
Download data: CEL
DataSet
Accession:
GDS3060
ID:
3060
5.

Gene expression profile for ectopic vs. eutopic endometrium

(Submitter supplied) Endometriosis is a common gynecological disorder characterized by pain and infertility, where the lesions disseminate everywhere in the body with a preference for the pelvis. In that, it could be regarded as a “benign metastatic disease”, since its issue is not fatal. However, the molecular bases of this intriguing clinical condition are not well known. The objective of this study is to characterize the transcriptome differences between eutopic vs ectopic endometrium with a special interest in pathways involved in cancerogenesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7304
4 Samples
Download data: TXT
Series
Accession:
GSE12768
ID:
200012768
6.

Expression and methylation profiles of choriodecidua from pregnant women affected with deep endometriosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Methylation profiling by array
Platforms:
GPL13534 GPL17425
12 Samples
Download data: PAIR
Series
Accession:
GSE57832
ID:
200057832
7.

Profile of differential expression and DNA methylation status in choriodecidua of women affected with severe endometriosis [DNA methylation]

(Submitter supplied) Endometriosis is a common gynecological disease that affects 10-20% of women in child-bearing age. It is defined by the presence of endometrial tissues outside the uterus. The causes remain elusive, but the endometrium of these patients differs profoundly from that of disease-free subjects. During pregnancy, the maternal-fetal interface is built onto decidualized endometrium. We investigated whether this interface is normal when the subjects suffer of endometriosis and showed remarkly properties of eutopic endometrium from endometriosis-affected women to spontaneously develop endometriotic-like lesions within direct contact to non-uterine tissues.
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL13534
6 Samples
Download data: TXT
Series
Accession:
GSE57831
ID:
200057831
8.

Profile of differential expression and DNA methylation status in choriodecidua of women affected with severe endometriosis [Gene Expression]

(Submitter supplied) Endometriosis is a common gyncological disease that affects 10-20% of women in child-bearing age. It is defined by the presence of endometrial tissues outside the uterus. The causes remain elusive, but the endometrium of these patients differs profoundly from that of disease-free subjects. During pregnancy, the maternal-fetal interface is built onto decidualized endometrium. We investigated whether this interface is normal when the subjects suffer of endometriosis and showed remarkly properties of eutopic endometrium from endometriosis-affected women to spontaneously develop endometriotic-like lesions within direct contact to non-uterine tissues.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17425
6 Samples
Download data: PAIR, TXT
Series
Accession:
GSE57733
ID:
200057733
9.

Expression data from in vitro decidualized human uterine fibroblast cells (HuF cells) with or without NOTCH1 silencing

(Submitter supplied) Decidualization is a critical process for embryo implatation during which uterine stromal fibroblasts are transformed into large, epithelioid-like decidual cell. NOTCH1 is recepotor of Notch signaling that plays important roles for cell-cell communication, which involves gene regulatory mechanisms that control multiple cellular differentiation processes during embryonic and adult life. Here we silenced NOTCH1 by shRNA in HuF cells and studied how it affects decidualization
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
8 Samples
Download data: CEL
Series
Accession:
GSE61827
ID:
200061827
10.

Endometriosis transcription profiling

(Submitter supplied) Endometriosis is a complex pathological condition in which multiple components are involved in the disease development and clinical outcome. Endometriosis is mainly an inflammatory codition estrogen-dependent, with unknown pathogenesis, that is characterized by dissemination of edometrium tissue in ectopic position (ovary or pelvic peritoneum). Two main theories rise the pathologic onset: the presence of retrograde menstruation and celomic metaplasia in the pelvic peritoneum, that can occur for development defects. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5339
Platform:
GPL571
22 Samples
Download data: CEL
Series
Accession:
GSE25628
ID:
200025628
11.
Full record GDS5339

Endometriosis: ectopic and eutopic endometrium

Analysis of ectopic endometria and eutopic endometria from endometriosis patients. Endometriosis is characterized by the presence of endometrial tissue at extra-uterine sites. Results provide insight into the molecular mechanisms underlying endometriosis pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 3 tissue sets
Platform:
GPL571
Series:
GSE25628
22 Samples
Download data: CEL
DataSet
Accession:
GDS5339
ID:
5339
12.

Macrophages in eutopic endometrium endometriosis

(Submitter supplied) Comparison of macrophages M1 (M1) and M2 (M2) from eutopic endometrium from women with and without endometriosis
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
18 Samples
Download data: TXT
Series
Accession:
GSE130435
ID:
200130435
13.

Analysis of ectopic human endometrium and peritoneal tissues in nude mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL81 GPL8300 GPL96
36 Samples
Download data: CEL
Series
Accession:
GSE11769
ID:
200011769
14.

Nude mouse model of endometriosis

(Submitter supplied) The pathophysiology of endometriotic lesion development remains unclear but involves a complex interaction between ectopic endometrium and host peritoneal tissues. We hypothesised that disruption of this interaction was likely to suppress endometriotic lesion formation. We hoped to delineate the molecular and cellular dialogue between ectopic human endometrium and peritoneal tissues in nude mice, as a first step towards testing this hypothesis. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL8300 GPL81
18 Samples
Download data: CEL
Series
Accession:
GSE11768
ID:
200011768
15.

Euctopic and ectopic human endometrium (endometriosis)

(Submitter supplied) The pathophysiology of endometriotic lesion development remains unclear but involves a complex interaction between ectopic endometrium and host peritoneal tissues. We hypothesised that disruption of this interaction was likely to suppress endometriotic lesion formation. We hoped to delineate the molecular and cellular dialogue between ectopic human endometrium and peritoneal tissues in nude mice, as a first step towards testing this hypothesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
18 Samples
Download data: CEL
Series
Accession:
GSE11691
ID:
200011691
16.

Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis

(Submitter supplied) Endometriosis is defined as the presence of endometrial tissue (eutopic tissue) outside the uterus (ectopic tissue). We assessed differentially expressed microRNAs in ectopic endometrium compared with eutopic endometrium.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL7372
3 Samples
Download data: TXT
Series
Accession:
GSE26346
ID:
200026346
17.

Unique Transcriptome, Pathways, and Networks in the Human Endometrial Fibroblast Response to Progesterone in Endometriosis

(Submitter supplied) Eutopic endometrium in endometriosis has molecular evidence of resistance to progesterone (P4) and activation of the PKA pathway in the stromal compartment. To investigate global and temporal responses of eutopic endometrium to P4, we compared early (6-h), intermediate (48-h), and late (14-day) transcriptomes, signaling pathways, and networks of human endometrial stromal fibroblasts (hESFs) from women with endometriosis (hESFendo) to hESFs from women without endometriosis (hESFnonendo). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
80 Samples
Download data: CEL, TXT
Series
Accession:
GSE35287
ID:
200035287
18.

Promoter methylation profiles for ectopic vs. eutopic endometrium in SUP, VES and OME

(Submitter supplied) Several lines of evidence indicate that endometriosis could be partially due to epigenetic dysregulations. Hypermethylation of some key gene promoters, such as progesterone receptor or aromatase, has been reported to be associated with silencing of these genes. However, it is unknown whether global alterations in DNA methylation are a hallmark of endometriosis and to what extent they are involved in its pathogenesis. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL5082
4 Samples
Download data: BAR, CEL, TXT
Series
Accession:
GSE16079
ID:
200016079
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