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Links from GEO DataSets

Items: 20

1.
Full record GDS3104

Insulin-resistant polycystic ovary syndrome: muscle

Analysis of vastus lateralis muscles from women with insulin-resistant polycystic ovary syndrome (PCOS). Insulin resistance in skeletal muscles is a risk factor for the development of type 2 diabetes in women with PCOS. Results provide insight into the pathogenesis of insulin resistance in PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE6798
29 Samples
Download data: CEL
DataSet
Accession:
GDS3104
ID:
3104
2.

Reduced expression of mitochondrial oxidative metabolism genes in skeletal muscle of women with PCOS

(Submitter supplied) Recently, abnormalities in mitochondrial oxidative phosphorylation (OXPHOS) have been implicated in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin resistance in the polycystic ovary syndrome (PCOS). Using the HG-U133 Plus 2.0 expression array from Affymetrix, we analyzed gene expression in skeletal muscle from obese women with PCOS (n=16) and age- and body mass index-matched control women (n=13) metabolically characterized by euglycemic-hyperinsulinemic clamp and indirect calorimetry. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3104
Platform:
GPL570
29 Samples
Download data: CEL
Series
Accession:
GSE6798
ID:
200006798
3.

Gene expression profiling in skeletal muscle of PCOS after pioglitazone therapy

(Submitter supplied) Insulin resistance is a common metabolic abnormality in women with PCOS and leads to an elevated risk of type 2 diabetes. Studies have shown that thiazolidinediones (TZD) improve metabolic disturbances in PCOS patients. We hypothesized that the effect of TZD in PCOS is in part mediated by changes in the transcriptional profile of muscle favoring insulin sensitivity. Using Affymetrix microarrays, we examined the effect of pioglitazone (30 mg/day for 16 weeks) on gene expression in skeletal muscle of 10 obese women with PCOS metabolically characterized by a euglycemic-hyperinsulinemic clamp. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS4132 GDS4133
Platform:
GPL570
43 Samples
Download data: CEL
Series
Accession:
GSE8157
ID:
200008157
4.
Full record GDS4133

Obese women with polycystic ovary syndrome and obese, healthy women: skeletal muscle

Analysis of skeletal muscle from obese women with polycystic ovary syndrome (PCOS) and obese, healthy women. Results provide insight into whether pioglitazone ameliorates preexisting abnormalities in PCOS patients.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE8157
23 Samples
Download data: CEL
5.
Full record GDS4132

PPAR-γ agonist pioglitazone effect on obese women with polycystic ovary syndrome: skeletal muscle

Analysis of skeletal muscle from obese women with polycystic ovary syndrome (PCOS) before and after thiazolidinedione (TZD) pioglitazone treatment. TZDs improve metabolic disturbances in PCOS patients. Results provide insight into the molecular mechanisms underlying the effect of TZD in PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL570
Series:
GSE8157
20 Samples
Download data: CEL
6.

Microarray skeletal muscle PPARalpha overexpressing mice

(Submitter supplied) This experiment was conducted to identify target genes of the peroxisome proliferator-activated receptor alpha (PPARa) in skeletal muscle of transgenic mice that overexpressed PPARa. The following abstract from the published manuscript describes the major findings of this work. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2289
Platform:
GPL339
4 Samples
Download data
Series
Accession:
GSE5777
ID:
200005777
7.
Full record GDS2289

PPARalpha overexpression effect on skeletal muscles

Analysis of skeletal muscles of transgenics (trs) overexpressing PPARalpha. Trs overexpressing PPARalpha develop glucose intolerance despite protection from diet-induced obesity. Results provide insight into the role of PPARalpha in the development of insulin-resistant diabetes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE5777
4 Samples
Download data
8.

A PGC-1alpha-dependent decrease in mitochondrial oxidative metabolism in muscle of humans with inherited insulin resistance

(Submitter supplied) We used microarrays to assess gene expression profiling of 6 patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR) and 10 matched healthy controls
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4897
Platform:
GPL571
16 Samples
Download data: CEL
Series
Accession:
GSE36297
ID:
200036297
9.
Full record GDS4897

Skeletal muscle of patients with inherited insulin resistance

Analysis of muscle from patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR). This mutation is associated with inherited insulin resistance. Results provide insight into molecular mechanisms underlying insulin resistance in skeletal muscle.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL571
Series:
GSE36297
16 Samples
Download data: CEL
DataSet
Accession:
GDS4897
ID:
4897
10.

Transcription profiling of myotubes from patients with type 2 diabetes

(Submitter supplied) Microarray-based studies of skeletal muscle from patients with type 2 diabetes and high-risk individuals have demonstrated that insulin resistance and reduced mitochondrial biogenesis co-exist early in the pathogenesis of type 2 diabetes independent of hyperglycaemia and obesity. It is unknown whether reduced mitochondrial biogenesis or other transcriptional alterations co-exist with impaired insulin-responsiveness in primary human muscle cells from patients with type 2 diabetes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3681
Platform:
GPL8300
20 Samples
Download data: CEL
Series
Accession:
GSE12643
ID:
200012643
11.
Full record GDS3681

Type 2 diabetes: myotube

Analysis of myotube cell lines established from type 2 diabetes (T2D) subjects. Insulin resistance and reduced mitochondrial biogenesis coexist early in T2D pathogenesis independent of hyperglycemia and obesity. Results provide insight into the effect of T2D on developing skeletal muscle cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL8300
Series:
GSE12643
20 Samples
Download data: CEL
DataSet
Accession:
GDS3681
ID:
3681
12.

Zucker diabetic fatty (ZDF)/Zucker lean control (ZLC) comparisons

(Submitter supplied) Gene expression profiles in tissues of Zucker diabetic fatty (ZDF) rats compared with age matched Zucker lean control (ZLC) rats. Keywords: other
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS1767
Platform:
GPL1002
24 Samples
Download data
Series
Accession:
GSE1080
ID:
200001080
13.
Full record GDS1767

Zucker diabetic fatty model of type 2 diabetes: various insulin-sensitive tissues

Analysis of adipose, skeletal muscle, and liver tissues of Zucker diabetic fatty animals at pre-diabetic and diabetic stages. ZDF animals have a mutated leptin receptor. Results provide insight into the molecular mechanisms responsible for insulin resistance and progression to type 2 diabetes.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, log ratio, 2 age, 3 tissue sets
Platform:
GPL1002
Series:
GSE1080
24 Samples
Download data
DataSet
Accession:
GDS1767
ID:
1767
14.

Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients

(Submitter supplied) Objective: The etiology of PCOS is mostly unknown. Existing data support both genetic and environmental factors in its pathogenesis. Design: Prospective case - control study. Setting: University Hospital. Patients: 25 patients undergoing IVF-ICSI treatment. Intervention: Genome-wide oligonucleotide microarray technology was used to study differential gene-expression patterns of cultured human cumulus cells from IVF patients divided into 4 groups according to disease state (PCOS vs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3841
Platform:
GPL570
23 Samples
Download data: CEL
Series
Accession:
GSE10946
ID:
200010946
15.
Full record GDS3841

Lean and overweight-obese polycystic ovary syndrome patients: cultured cumulus cells

Analysis of cumulus cells from lean and overweight-obese polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization (IVF). PCOS is a heterogeneous endocrinopathy in women of reproductive age, mostly associated with ovulation failure. Results provide insight into PCOS pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 2 other sets
Platform:
GPL570
Series:
GSE10946
23 Samples
Download data: CEL
DataSet
Accession:
GDS3841
ID:
3841
16.

Theca cell gene expression

(Submitter supplied) Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects 5-10% of reproductive aged women. The hallmark characteristic of PCOS is increased ovarian androgen synthesis. Previous studies by our laboratory demonstrated that increased androgen synthesis is a stable biochemical phenotype of PCOS theca cells which are the primary source of ovarian androgen production. The increase in theca cell steroidogenesis was due to an increase in expression of several steroidogenic enzymes including CYP17 and CYP11A but not StAR. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS1050 GDS1051
Platforms:
GPL96 GPL97
26 Samples
Download data: CEL, EXP
Series
Accession:
GSE1615
ID:
200001615
17.
Full record GDS1051

Valproic acid effect on theca cells (HG-U133B)

Analysis of normal theca cells treated with 500 uM valproic acid (VPA), an anti-epilipetic that induces polycystic ovary syndrome (PCOS)-like symptoms. Theca cells from PCOS patients also examined. Results provide insight into the underlying mechanisms contributing to VPA-induced PCOS-like symptoms.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 disease state sets
Platform:
GPL97
Series:
GSE1615
13 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS1051
ID:
1051
18.
Full record GDS1050

Valproic acid effect on theca cells (HG-U133A)

Analysis of normal theca cells treated with 500 uM valproic acid (VPA), an anti-epilipetic that induces polycystic ovary syndrome (PCOS)-like symptoms. Theca cells from PCOS patients also examined. Results provide insight into the underlying mechanisms contributing to VPA-induced PCOS-like symptoms.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 disease state sets
Platform:
GPL96
Series:
GSE1615
13 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS1050
ID:
1050
19.

Type 2 diabetes and insulin resistance

(Submitter supplied) Global transcript profiling to identify differentially expressed skeletal muscle genes in insulin resistance, a major risk factor for Type II (non-insulin-dependent) diabetes mellitus. Compared gene expression profiles of skeletal muscle tissues from 18 insulin-sensitive versus 17 insulin-resistant equally obese, non-diabetic Pima Indians. Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS157 GDS158 GDS160 GDS161 GDS162
5 related Platforms
50 Samples
Download data
Series
Accession:
GSE121
ID:
200000121
20.

Insulin resistant muscle sample pool 5

(Submitter supplied) Muscle sample pool #5 from 2 insulin resistant subjects. Keywords: parallel sample
Organism:
Homo sapiens
Type:
Expression profiling by array
5 related Platforms
5 Samples
Download data
Series
Accession:
GSE73
ID:
200000073
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