Similar studies for GEO DataSets (Select 3151) - GEO DataSets

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Items: 3

Select item 31511.

Beta-galactoside alpha-2,6-sialyltransferase deficient mammary tumors

Analysis of mammary tumors from animals lacking beta-galactoside alpha-2,6-sialyltransferase (ST6Gal-I). Increased ST6Gal-I expression is reported in several carcinomas including breast carcinoma. Results provide insight into the role of ST6Gal-I in tumor progression.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE9447
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3151

ID:: 3151

Select item 2000094472.

Alpha2-6-linked Sialic Acids on N-Glycans Modulate Carcinoma Differentiation In Vivo

(Submitter supplied) Sialic acids on vertebrate cell surfaces mediate many biological roles. Altered expression of certain sialic acid types or their linkages can have prognostic significance in human cancer. A classic but unexplained example is enhanced α2-6-sialylation on N-glycans, resulting from over-expression of the Golgi enzyme β-galactoside:α2-6-sialyltransferase (ST6Gal-I). Previous data supporting a role for the resulting Siaα2-3Galβ1-4GlcNAc (Sia6LacNAc) structure in tumor biology were based on in vitro studies in transfected carcinoma cells, in which increased Sia6LacNAc on β1-integrins enhanced their binding to ligands, and stimulated cell motility. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3151
Platform:: GPL1261
4 Samples

Download data: CEL, CHP

Series

Accession:: GSE9447

ID:: 200009447

Select item 2001585273.

Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells

(Submitter supplied) RNA-Seq results suggested that epithelial to mesenchymal transition (EMT) -related pathways were upregulated in the metastatic subclones. Furthermore, forced expression of ST6Gal-I in the parental Suit2 line was sufficient to upregulate EMT, indicating a functional role for ST6Gal-I in this process.