GEO DataSets

Analysis of heart left ventricles of diabetic animals. Diabetes induced by streptozotocin treatment. Results provide insight into the molecular mechanisms underlying diabetes-induced cardiac dysfunction.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL341

Series:

GSE6880

6 Samples

Download data: CEL

(Submitter supplied) 8 week old rats injected with streptozotocin or buffer alone at age of 8 weeks, heart obtained at 12 weeks (thus animals were diabetic for 4 weeks). Left vent of heart. Keywords: Disease state analysis (diabetes)

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3153

Platform:

GPL341

6 Samples

Download data: CEL

(Submitter supplied) Experiment protocol: Experiment was performed on 10 to 15 weeks old male NMRI mice (Harlan, Holland) housed in standard conditions (temperature 22°C, humidity 60 ± 10 %, artificial light from 8.00 am to 8.00 pm, normally 5 animals per cage). Animals had free access to tap water and food pellets (R36, Labfor, Stockholm, Sweden). Animals were randomly divided into healthy and diabetic groups. The diabetic group received a single peritoneal injection of streptozotocin (STZ, Sigma-Aldrich, France, 180 mg/kg) dissolved in sodium citrate buffer solution (0.1 mol/l, pH 4.5) to induce experimental diabetes similar to type 1. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1541

Platform:

GPL81

12 Samples

Download data: CEL, EXP

Analysis of experimental type 1 diabetic skeletal muscle subjected to endurance training. Diabetic muscle atrophy is accompanied by changes in the extracellular matrix (ECM). Results suggest the diabetes-induced decrease in gene expression of ECM proteins is partially attenuated by training.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 protocol, 3 time sets

Platform:

GPL81

Series:

GSE1659

12 Samples

Download data: CEL, EXP

(Submitter supplied) RNA was obtained from rear leg muscle of normal and diabetic rats in the presence and absence of oral treatment with vandyl sulfate. Diabetes was induced with streptozotocin and expression profiles were determined using Affymetrix Rat Genechip U34A. The effect of treatment and disease on gene expression was examined. Keywords: vanadium treatment

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1913

Platform:

GPL85

20 Samples

Download data

Expression profiling of rear leg muscles of diabetic Wistars treated with vanadyl sulfate. Diabetes induced with streptozotocin (STZ). Studies show that vanadyl sulfate relieves diabetic hyperglycemia.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 2 disease state sets

Platform:

GPL85

Series:

GSE3068

20 Samples

Download data

(Submitter supplied) Analysis of gene expression changes in the LV of a rodent heart that occur with uncontrolled diabetes We used microarrays to detail the global changes that occur in gene expression in the LV of the heart as a result of STZ-induced diabetes. Keywords: single time point, comparison control animal v. diabetic animal

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

14 Samples

Download data: CEL

(Submitter supplied) 8 week old rats injected with streptozotocin or buffer alone at age of 8 weeks, diaphragm muscle obtained at age of 12 weeks (thus animals were diabetic for 4 weeks) Keywords: Disease state analysis (diabetes)

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

6 Samples

Download data

(Submitter supplied) Comparison of gene expression of heart (left vent) and diaphragm of normal Sprague Dawley rats, young adult Keywords: Cell type comparison

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3224

Platform:

GPL341

12 Samples

Download data: CEL

Analysis of normal heart left ventricle and diaphragm of young-adult Sprague Dawley males. Concurrent rhythmic contractions of the diaphragm and heart are needed to sustain life. Results provide insight into transcriptional strategies for ensuring long-term energy supplies in these two muscles.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL341

Series:

GSE6943

12 Samples

Download data: CEL

(Submitter supplied) Effect of type 1 diabetes (induced by streptozotocin 60 mg/kg) on lung gene expression. Wistar rats, male. At age 8 weeks control rats got IP buffer, diabetic rats got streptozotocin. At age 12 weeks animals were anesthetized and lungs removed. RNA was extracted with Trizol, and gene expression array analysis was performed using Affymetrix RAE 230A microarrays according to the directions from the manufacturer. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS5255

Platform:

GPL341

12 Samples

Download data: CEL

Analysis of lungs of diabetic animals. Diabetes induced by streptozotocin treatment. Results provide insight into the impact of diabetes on the cellular and molecular processes in the lung.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL341

Series:

GSE15900

12 Samples

Download data: CEL

(Submitter supplied) Type 2 diabetes differs from type 1 diabetes in its pathogenesis. Type 1 diabetic diaphragm has altered gene expression which includes lipid and carbohydrate metabolism, ubiquitination and oxidoreductase activity. The objectives of the present study were to assess respiratory muscle gene expression changes in type 2 diabetes and to determine whether they are greater for the diaphragm than an upper airway muscle. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

22 Samples

Download data: CEL, CHP