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Links from GEO DataSets

Items: 12

1.
Full record GDS3158

Rheumatoid arthritis-related cartilage destruction model: chondrocytes

Analysis of chondrocytes treated with a supernatant from SV40 T-antigen immortalized human synovial fibroblasts derived from a patient with rheumatoid arthritis (RA). Results provide insight into the molecular mechanism underlying RA-related cartilage destruction.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent sets
Platform:
GPL96
Series:
GSE10024
6 Samples
Download data: CEL, EXP
2.

Key Regulatory Molecules of Cartilage Destruction in Rheumatoid Arthritis: An in vitro Study

(Submitter supplied) We have studied the expression profile of 3D cultured human chondrocytes that were stimulated with supernatant of synovial fibroblasts derived from a RA patient (RASF=HSE cell line) and from a normal donor (NDSF=K4IM cell line), respectively. For this purpose, passage 2 human chondrocytes were cultured for 14 days in alginate beads and subsequently stimulated for 48 hours with supernatant of RASF and NDSF. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3158
Platform:
GPL96
6 Samples
Download data: CEL, EXP
Series
Accession:
GSE10024
ID:
200010024
3.

Antirheumatic Drug Response in Human Chondrocytes: Potential Molecular Targets to Stimulate Cartilage Regeneration

(Submitter supplied) Rheumatoid arthritis (RA) leads to progressive destruction of articular structures. Despite recent progress in controlling inflammation and pain, little cartilage repair has yet been observed. This in vitro study aims to determine the role of chondrocytes in RA-related cartilage destruction and antirheumatic drug-related regenerative processes. Human chondrocytes were three-dimensionally cultured in alginate beads. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
20 Samples
Download data: CEL, EXP, TXT
Series
Accession:
GSE12860
ID:
200012860
4.

Murine chondrocytes: Control vs Ad-Epas1 infected

(Submitter supplied) Transcriptional profiling of mouse chondrocytes comparing chondrocytes infected with empty adenovirus and Epas1 adenovirus. RNA was extracted from each chondrocytes. We used microarrays to determine the effect of Epas1 overexpression on chondrocytes and identify the noble regulatory molecules during osteoarthritic pathogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
4 Samples
Download data: TXT
Series
Accession:
GSE73659
ID:
200073659
5.

Murine fibroblast-like synoviocytes: Control vs Ad-Epas1 infected

(Submitter supplied) Transcriptional profiling of mouse fibroblast-like synoviocytes (FLS) comparing FLS infected with empty adenovirus and Epas1 adenovirus. RNA was extracted from each FLS. We used microarrays to determine the effect of Epas1 overexpression on FLS and identifying the noble regulatory molecules during rheumatoid arthritic pathogenesis
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
6 Samples
Download data: CEL
Series
Accession:
GSE73658
ID:
200073658
6.

Adult Human Chondrocyte Response to IL-1B

(Submitter supplied) IL-1B is an important cytokine that is often found to be up-regulated during osteoarthritic and rheumatoid joint diseases. It is viewed as a catabolic factor, inducing enzymes that allow for the degradation of the cartilage extracellular matrix and also has essential roles as an autocrine and paracrine factor in fibronectin fragment-mediated degradation. It can also reduce the synthesis of the major cartilage components, type II collagen and aggrecan. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6824
4 Samples
Download data: TXT
Series
Accession:
GSE11427
ID:
200011427
7.

Microrray expression data of Osteoarthritis synovial fibroblasts (OASF) transfected with TBX5

(Submitter supplied) TBX5 is hypomethylated in Rheumatoid Arthritis synovial fibroblasts (RASF). Hypomethylation increased the TBX5 expression in RASF. We performed a microarray expression analysis upon TBX5 overexpression to find TBX5 molecular targets.TBX5 belongs to the T-box transcription factor family all of which possess a T-box DNA binding domain in their sequence. It has been shown to play an important role in tissue development and cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5188
4 Samples
Download data: CEL
Series
Accession:
GSE60162
ID:
200060162
8.

Stimulation of RA SFBs with IL1 or PDGF-D

(Submitter supplied) Synovial fibroblasts of 6 RA patients were treated with IL1 or PDGF-D. The aim of this study was to outline mechanism of the disease RA by a treatment with one of these cytokines.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15445
60 Samples
Download data: CEL
Series
Accession:
GSE58203
ID:
200058203
9.

Adapted Boolean Network Models for Extracellular Matrix Formation

(Submitter supplied) Background Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by joint destruction and perpetuated by the synovial membrane (SM). In the inflamed SM, activated synovial fibroblasts (SFB) form the major cell type promoting development and progression of the disease by an abnormal expression/secretion of pro-inflammatory cytokines, tissue-degrading enzymes resulting in a predominant degradation of the extra-cellular matrix (ECM), and collagens causing joint fibrosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
60 Samples
Download data: CEL, CHP
Series
Accession:
GSE13837
ID:
200013837
10.

Culture effects on rheumatoid arthrits synovial fibroblasts

(Submitter supplied) Comparison between early passage to later passages of rheumatoid arthritis synovial fibroblast (RASF) populations using two different AtlasTM Human Arrays Gene expression changes during culture with increasing number of changes at higher passages depending on individual expression pattern of the respective cell populations
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL139 GPL131
112 Samples
Download data
Series
Accession:
GSE21385
ID:
200021385
11.

Human bone marrow-derived mononuclear cells (BMMC): rheumatoid arthritis vs. osteoarthritis

(Submitter supplied) Gene expression profiling of BMMC from patients with rheumatoid arthritis (RA) vs. osteoarthritis (OA).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
19 Samples
Download data: CEL
Series
Accession:
GSE27390
ID:
200027390
12.

Gene expression of the intermediate and outer interzone of murine embryos at 15.5 days of gestation

(Submitter supplied) Nascent embryonic joints, interzones, contain a distinct cohort of progenitor cells responsible for the formation of the majority of articular tissues. However, to date the interzone has largely been studied using in situ analysis for candidate genes in the context of the embryo rather than using an unbiased genome wide expression analysis on isolated interzone cells, leaving significant controversy regarding the exact role of the intermediate and outer interzone layers in joint formation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
6 Samples
Download data: TXT
Series
Accession:
GSE51098
ID:
200051098
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