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Links from GEO DataSets

Items: 18

1.
Full record GDS3160

Methotrexate resistant colon cancer cell line

Analysis of HT29 derived colon cancer cells resistant to the anticancer drug methotrexate (MTX). Results provide insight into the molecular mechanisms contributing to MTX resistance.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 cell line sets
Platform:
GPL571
Series:
GSE9412
6 Samples
Download data: CEL
DataSet
Accession:
GDS3160
ID:
3160
2.

Transcriptional regulation of aldo-keto reductase 1C1 in human colon cancer cells resistant to methotrexate

(Submitter supplied) The abstract of the associated publication (Selga E, Noé V, Ciudad CJ. Biochemical Pharmacology, 2008) is the following: While studying differentially expressed genes between sensitive and 10-5 M Methotrexate (MTX) resistant HT29 human colon cancer cells, we identified some members of the aldo-keto reductase (AKR) superfamily. The study was followed with the member AKR1C1 (EC 1.1.1.213), validating its increase in mRNA and protein levels in MTX resistant cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3160
Platform:
GPL571
6 Samples
Download data: CEL
Series
Accession:
GSE9412
ID:
200009412
3.

Role of Caveolin 1, E-Cadherin, Enolase 2 and PKCa on resistance to methotrexate in human HT29 colon cancer cells

(Submitter supplied) A summary of the work associated to these microarrays is the following: Methotrexate (MTX) is one of the earliest cytotoxic drugs used in cancer therapy, and despite the isolation of multiple other folate antagonists, methotrexate maintains its significant role as a treatment for different types of cancer and other disorders. The usefulness of treatment with methotrexate is limited by the development of drug resistance, which may be acquired through different ways. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3330
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE11440
ID:
200011440
4.
Full record GDS3330

Methotrexate-resistant HT29 colon adenocarcinoma cell line

Analysis of HT29 colon cancer cells sensitive or resistant to methotrexate (MTX). MTX is used in the treatment of cancer. Chemotherapy effectiveness in cancer cells is compromised by development of drug resistance. Results provide insight into molecular mechanisms associated with drug resistance.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 cell line sets
Platform:
GPL570
Series:
GSE11440
6 Samples
Download data: CEL
5.

Expression data from AKR1C1 over-expression in Cal-27 cells or knockdown in HSC-2 cells, respectively

(Submitter supplied) To exmaine the AKR1C1 controls transcriptome in HNSCC cells, we preformed the Affymetrix Human Genome U133 Plus 2.0 Array with empty vector or AKR1C1 expression vector in Cal-27 cells and shLuc control or shAKR1C1 in HSC-2 cells
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE119444
ID:
200119444
6.

Underexpression of miR-224 in methotrexate resistant human colon cancer cells

(Submitter supplied) A summary of the work associated to these microarrays is the following: MicroRNAs (miRNAs) are small non-coding RNAs involved in RNA silencing that play a role in many biological processes. They are involved in the development of many diseases, including cancer. Extensive experimental data show that they play a role in the pathogenesis of cancer as well as the development of drug resistance during treatment. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8227
6 Samples
Download data: GPR, TXT
Series
Accession:
GSE28547
ID:
200028547
7.

RNA-seq data of endometrium from Yorkshire pigs

(Submitter supplied) RNA-seq data of endometrium from Yorkshire pigs
Organism:
Sus scrofa
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19176
2 Samples
Download data: CSV
Series
Accession:
GSE141564
ID:
200141564
8.

AKR1C enzymes sustain therapy resistance in pediatric T-ALL

(Submitter supplied) Although intensification of chemotherapy approaches considerably increased the outcome of pediatric T-cell Acute Lymphoblastic Leukemia (T-ALL) patients, a subgroup of them still experience treatment failure and relapse. In this context, we hypothesized that the Nrf2 signalling and its downstream effectors could be involved in sustain therapy resistance in T-ALL, as previously reported in other cancers. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
54 Samples
Download data: CEL
Series
Accession:
GSE87865
ID:
200087865
9.

Networking of differentially expressed genes in human cancer cell lines resistant to methotrexate

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
42 Samples
Download data: CEL
Series
Accession:
GSE16648
ID:
200016648
10.

Networking of differentially expressed genes in human Saos-2 osteosarcoma cells resistant to methotrexate

(Submitter supplied) A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through the expression of genes. To address this issue in the case of drug resistance, we constructed Biological Association Networks of genes differentially expressed in cell lines resistant to methotrexate (MTX). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE16089
ID:
200016089
11.

Networking of differentially expressed genes in human K562 erythtoblastic leukemia cells resistant to methotrexate

(Submitter supplied) A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through the expression of genes. To address this issue in the case of drug resistance, we constructed Biological Association Networks of genes differentially expressed in cell lines resistant to methotrexate (MTX). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE16085
ID:
200016085
12.

Networking of differentially expressed genes in human MIA PaCa2 pancreatic cancer cells resistant to methotrexate

(Submitter supplied) A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through the expression of genes. To address this issue in the case of drug resistance, we constructed Biological Association Networks of genes differentially expressed in cell lines resistant to methotrexate (MTX). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE16082
ID:
200016082
13.

Networking of differentially expressed genes in human MDA-MB-468 breast cancer cells resistant to methotrexate

(Submitter supplied) A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through the expression of genes. To address this issue in the case of drug resistance, we constructed Biological Association Networks of genes differentially expressed in cell lines resistant to methotrexate (MTX). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE16080
ID:
200016080
14.

Networking of differentially expressed genes in human MCF7 breast cancer cells resistant to methotrexate

(Submitter supplied) A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through the expression of genes. To address this issue in the case of drug resistance, we constructed Biological Association Networks of genes differentially expressed in cell lines resistant to methotrexate (MTX). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE16070
ID:
200016070
15.

Networking of differentially expressed genes in CaCo2 human colon cancer cells resistant to methotrexate

(Submitter supplied) A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through the expression of genes. To address this issue in the case of drug resistance, we constructed Biological Association Networks of genes differentially expressed in cell lines resistant to methotrexate (MTX). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE16066
ID:
200016066
16.

Genome position and gene amplification - expressional profiling of methotrexate resistant colonies

(Submitter supplied) We investigated the influence of genome position on propensity to amplify. First, we integrated a mutant form of DHFR into different positions in the human genome, challenged cells with methotrexate and then studied the genomic alterations arising in drug resistant cells. We observed site specific differences in methotrexate sensitivity, organization of amplicons and amplification frequency. One site was uniquely associated with a significantly enhanced propensity to amplify and recurrent amplicon boundaries, possibly implicating a rare folate sensitive fragile site in initiating amplification. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4419
12 Samples
Download data: TIFF, TXT
Series
Accession:
GSE6361
ID:
200006361
17.

Genome position and gene amplification - higher resolution mapping of amplicons

(Submitter supplied) We investigated the influence of genome position on propensity to amplify. First, we integrated a mutant form of DHFR into different positions in the human genome, challenged cells with methotrexate and then studied the genomic alterations arising in drug resistant cells. We observed site specific differences in methotrexate sensitivity, organization of amplicons and amplification frequency. One site was uniquely associated with a significantly enhanced propensity to amplify and recurrent amplicon boundaries, possibly implicating a rare folate sensitive fragile site in initiating amplification. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL4422
6 Samples
Download data: TIFF, TXT
Series
Accession:
GSE6360
ID:
200006360
18.

Genome Position and Gene Amplification

(Submitter supplied) Amplifications, regions of focal high level copy number change, lead to overexpression of oncogenes or drug resistance genes in tumors. Their presence is often associated with poor prognosis; however the use of amplification as a mechanism for overexpression of a particular gene in tumors varies. To investigate the influence of genome position on propensity to amplify, we integrated a mutant form of DHFR into different positions in the human genome, challenged cells with methotrexate and then studied the genomic alterations arising in drug resistant cells. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL4421
95 Samples
Download data: TIFF, TXT
Series
Accession:
GSE6262
ID:
200006262
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