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Items: 4

1.
Full record GDS3180

Estrogen effect on myometrium of ovariectomized females: time course

Analysis of myometria of ovariectomized animals following treatment with estradiol for 6 or 24 hours. Estrogen reduces the increased uterine sympathetic nerve density induced by ovariectomy. Results provide insight into the molecular mechanisms underlying estrogen-modulated sympathetic innervation.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL85
Series:
GSE9117
4 Samples
Download data: CEL, EXP
2.

Expression data from rat uterine myometrium -effect of estrogen

(Submitter supplied) Uterine tissue is highly responsive to estrogen, which plays a mayor role in sympathetic innervation remodeling in myometrium Microarrays were used to investigate which estrogen resposive myometrial proteins can be involved in innervation modulation Keywords: control vs. treatment, timepoints
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3180
Platform:
GPL85
4 Samples
Download data: CEL, EXP
Series
Accession:
GSE9117
ID:
200009117
3.

Transcriptomic effects of estradiol treatment on cultured human uterine smooth muscle cells

(Submitter supplied) The myometrium is an important reproductive tissue composed primarily of smooth muscle cells. Contractility of the myometrial smooth muscle cells during the estrous cycle and pregnancy is modulated by estrogen. Despite much research, little is known about the molecular mechanism by which estrogen regulates myometrial contractility. This study investigates global gene expression profile of cultured human uterine smooth muscle cells (hUtSMCs) following 17β-estradiol (E2) treatment using cDNA microarray technology. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8950
22 Samples
Download data: TXT
Series
Accession:
GSE51470
ID:
200051470
4.

Effect of prolonged stretch on transcript profile of human pregnant myometrium

(Submitter supplied) Context: Increased uterine stretch appears to increase the risk of preterm labour, but the mechanism is unknown. Objectives: To identify a targetable mechanism mediating the effect of stretch on human myometrium. Design: Myometrial explants, prepared from biopsies obtained at elective caesarean delivery, were either studied acutely, or were maintained in prolonged culture (up to 65 h) under tension with either a 0.6 g or 2.4 g mass, and compared using in vitro contractility, whole genome array, and qRT-PCR. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6883
18 Samples
Download data: TXT
Series
Accession:
GSE31329
ID:
200031329
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