GEO DataSets

Analysis of normal heart left ventricle and diaphragm of young-adult Sprague Dawley males. Concurrent rhythmic contractions of the diaphragm and heart are needed to sustain life. Results provide insight into transcriptional strategies for ensuring long-term energy supplies in these two muscles.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL341

Series:

GSE6943

12 Samples

Download data: CEL

(Submitter supplied) Comparison of gene expression of heart (left vent) and diaphragm of normal Sprague Dawley rats, young adult Keywords: Cell type comparison

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3224

Platform:

GPL341

12 Samples

Download data: CEL

(Submitter supplied) Normal young adult Sprague Dawley rats (male)

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

12 Samples

Download data: CEL

(Submitter supplied) 8 week old rats injected with streptozotocin or buffer alone at age of 8 weeks, diaphragm muscle obtained at age of 12 weeks (thus animals were diabetic for 4 weeks) Keywords: Disease state analysis (diabetes)

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

6 Samples

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(Submitter supplied) Glycerol kinase (GK) is at the interface of fat and carbohydrate metabolism and has been implicated in insulin resistance and type 2 diabetes mellitus (T2DM). To define GK’s role in insulin resistance, we examined gene expression in brown adipose tissue in a glycerol kinase (Gyk) knockout (KO) mouse model using microarray analysis. Global gene expression profiles of KO mice were distinct from wild type (WT) with 668 genes that were differentially expressed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2610

Platform:

GPL1261

7 Samples

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Analysis of brown adipose tissues from glycerol kinase (GK) knockout mutants. GK is at the interface of fat and carbohydrate metabolism and has been implicated in insulin resistance and type 2 diabetes mellitus. Results provide insight into the role of GK in insulin resistance.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE4656

7 Samples

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(Submitter supplied) It is unknown how soon the diaphragm begins to start the process of atrophy following the start of MV. We hypothesized that genes responsible for maintaining diaphragmatic contractile function, stress response, energy transduction would be altered over the course of a 5 hour cardiothoracic surgery.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4308

Platform:

GPL570

10 Samples

Download data: CEL

Analysis of paired diaphragm biopsies from 5 patients during cardiothoracic surgery: the 1st as soon as diaphragm was exposed, the 2nd as late in surgery as possible (4.9 ± 1.8 hrs between biopsies). Results provide insight into diaphragm muscle biology after prolonged cardiothoracic procedures.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 age, 5 individual, 2 specimen sets

Platform:

GPL570

Series:

GSE19533

10 Samples

Download data: CEL

(Submitter supplied) Aerobic capacity is a strong predictor of cardiovascular mortality. To determine the relationship between aerobic capacity and cardiac gene expression we examined genome-wide gene expression in hearts of rats artificially selected for high- and low running capacity (HCR and LCR, respectively) over 16 generations. HCR were born with an athletic phenotype, whereas LCR exhibited features of the metabolic syndrome. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3131

Platform:

GPL1355

16 Samples

Download data: CEL

Analysis of hearts from low (LCRs) and high capacity runners (HCRs) with or without exercise training. Aerobic capacity is a strong predictor of cardiovascular mortality. Results provide insight into the molecular basis for the difference in inborn aerobic capacity in the LCRs and HCRs.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 protocol, 2 strain sets

Platform:

GPL1355

Series:

GSE9445

16 Samples

Download data: CEL

(Submitter supplied) Analysis of gene expression changes in the LV of a rodent heart that occur with uncontrolled diabetes We used microarrays to detail the global changes that occur in gene expression in the LV of the heart as a result of STZ-induced diabetes. Keywords: single time point, comparison control animal v. diabetic animal

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

14 Samples

Download data: CEL

(Submitter supplied) Time and dose related expression profiles of rat right heart tissue in microsphere bead model for Pulmonary embolism Keywords: Time course and dose response in experimental PE

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3414

Platform:

GPL1355

45 Samples

Download data: CEL

Analysis of right ventricles (RV) of animals for up to 18 hours after injection with polystyrene microsphere beads to induce pulmonary embolism (PE). Animals injected with 1.3 or 2.0 million microspheres/100g body weight. Results provide insight into the mechanisms leading to RV failure after PE.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 3 dose, 3 time sets

Platform:

GPL1355

Series:

GSE6104

45 Samples

Download data: CEL

(Submitter supplied) 8 week old rats injected with streptozotocin or buffer alone at age of 8 weeks, heart obtained at 12 weeks (thus animals were diabetic for 4 weeks). Left vent of heart. Keywords: Disease state analysis (diabetes)

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3153

Platform:

GPL341

6 Samples

Download data: CEL

Analysis of heart left ventricles of diabetic animals. Diabetes induced by streptozotocin treatment. Results provide insight into the molecular mechanisms underlying diabetes-induced cardiac dysfunction.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL341

Series:

GSE6880

6 Samples

Download data: CEL

(Submitter supplied) High energy intake and, specifically, high dietary fat intake challenges the mammalian metabolism and correlates with many metabolic disorders, such as obesity and diabetes. Dietary restriction (DR) is, on the other hand, known to prevent the development of metabolic disorders. The current Western diets are highly enriched in fat and it is as yet unclear whether DR on a certain high-fat (HF) diet elicits similar beneficial effects on health. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3986

Platform:

GPL7202

36 Samples

Download data: TXT

Analysis of epididymal WAT from C57BL/6J adult males adapted to a high-fat diet for 3 wks, then fed a high-fat diet on an ad-libitum basis (HF-AL) or on a restricted basis (HF-DR) for 12 wks. Results provide insight into molecular mechanisms underlying improved metabolic health induced by HF-DR.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL7202

Series:

GSE27213

36 Samples

Download data: TXT

(Submitter supplied) Pulmonary vascular occlusions due to thromboemboli can result in pulmonary hypertension and right heart damage. Treatments to clear the vascular obstructions such as i.v. heparain or thrombolytics can resolve the hypertension but right ventricular damage often occurs first. Methods of protecting the right ventricle from hypertensive damage during the course of acute treatment to clear the thromboemboli are needed. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

20 Samples

Download data: CEL, CHP

(Submitter supplied) In the present study, we examined duodenal gene expression in rats subjected to immobilization, to elucidate the mechanism of the stress response in the duodenum. Keywords: stress response

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

2 Samples

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(Submitter supplied) We used high density oligonucleotide arrays to measure the relative expression levels of ~27,000 probe sets in the left ventricles of inbred rat strains; DA (high performing), Copenhagen (COP, low performing), as well as F1(COPxDA) rats bred from these two strains whose performance was intermediate relative to both parental strains. DA and COP rats differ for both intrinsic aerobic running capacity (assessed with a treadmill exercise test to exhaustion) and intrinsic cardiac performance (as assessed by the Langendorff-Neeley working heart model). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS778 GDS779 GDS780

Platforms:

GPL86 GPL87 GPL85

36 Samples

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