Similar studies for GEO DataSets (Select 3396) - GEO DataSets

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Items: 2

Select item 33961.

Rosiglitazone effect on kidneys

Analysis of kidneys from lean and obese animals fed a diet supplemented with rosiglitazone for 12 weeks. Rosiglitazone is a thiazolidinedione drug used to treat diabetes. Results provide insight into the mechanism of action of rosiglitazone.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 2 disease state sets

Platform:: GPL1355
Series:: GSE7193
12 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3396

ID:: 3396

Select item 2000071932.

Rosiglitazone effects on kidney gene expression

(Submitter supplied) Thiazolidinediones increase tissue insulin sensitivity and are protective against worsening of nephropathy and hypertension in diabetes. Mechanisms underlying protection at the renal level likely involve a variety of unknown changes in gene expression. We examined kidney gene expression in obese and lean Zucker rats in response to rosiglitazone (Avandia®), a peroxisome proliferator activated receptor (gamma-subtype) agonist. more...