GEO DataSets

Analysis of peripheral blood mononuclear cells treated with the recombinant staphylococcal superantigen (SAg) toxin SEI or SEB. SEI is located in the enterotoxin gene cluster (egc). Antibodies against non-egc SAgs are common in the healthy population, while those against egc SAgs are rare.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent, 3 individual sets

Platform:

GPL570

Series:

GSE11281

9 Samples

Download data: CEL

(Submitter supplied) The species Staphylococcus (S.) aureus harbors 19 superantigen gene loci, six of which are located in the enterotoxin gene cluster (egc). While these egc superantigens are far more prevalent in clinical S. aureus isolates than non-egc superantigens, they are not a prominent cause of toxic shock. Moreover, neutralizing antibodies against egc superantigens are very rare, even among carriers of egc-positive S. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3399

Platform:

GPL570

9 Samples

Download data: CEL

(Submitter supplied) Purpose: The goal of this study was to determine what genes and canonical pathways are altered by exposure of human keratinocytes to S. aureus superantigens TSST-1 or SEB; Methods: Primary human keratinocytes were treated with 100 ug purified TSST-1, SEB, or vehicle for 6 hours. RNA was extracted with Trizol, DNase treated, and purifed using a Qiagen column. RNAseq was used to assess gene expression. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

10 Samples

Download data: CSV, XLSX

(Submitter supplied) Staphylococcus aureus, a gram-positive bacterium, causes food poisoning and toxic shock syndrome through the production of superantigenic toxins known as Staphylococcal enterotoxins serotypes A-J (SEA, SEB, etc.) and toxic shock syndrome toxin-1 (TSST-1). A subset of these toxins have been classified as potential biothreat agents. The chronology of molecular events that could potentially characterize superantigenic toxicity and early pathogenesis is not well understood. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

19 Samples

Download data: TXT