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Links from GEO DataSets

Items: 20

1.
Full record GDS3411

Low doses of perfluorooctanoic acid effect on fetal liver and lung

Analysis of livers or lungs of fetuses dosed during gestation with up to 3 mg/(kg day) perfluorooctanoic acid (PFOA), an industrial chemical that induces growth deficits and mortality in murine neonates. Results provide insight into the molecular basis of PFOA-induced developmental toxicity.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 dose, 2 tissue sets
Platform:
GPL1261
Series:
GSE13044
29 Samples
Download data: CEL
DataSet
Accession:
GDS3411
ID:
3411
2.

Gene expression profiling in the lung and liver of low and high dose Perfluorooctanoic Acid exposed mouse fetuses

(Submitter supplied) Exposure to PFOA during gestation altered the expression of genes related to fatty acid catabolism in both the fetal liver and lung. In the fetal liver, the effects of PFOA were robust and also included genes associated with lipid transport, ketogenesis, glucose metabolism, lipoprotein metabolism, cholesterol biosynthesis, steroid metabolism, bile acid biosynthesis, phospholipid metabolism, retinol metabolism, proteosome activation, and inflammation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS3410 GDS3411
Platform:
GPL1261
59 Samples
Download data: CEL
Series
Accession:
GSE13044
ID:
200013044
3.
Full record GDS3410

High doses of perfluorooctanoic acid effect on fetal liver and lung

Analysis of livers or lungs of fetuses dosed during gestation with up to 10 mg/(kg day) perfluorooctanoic acid (PFOA), an industrial chemical that induces growth deficits and mortality in murine neonates. Results provide insight into the molecular basis of PFOA-induced developmental toxicity.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 dose, 2 tissue sets
Platform:
GPL1261
Series:
GSE13044
30 Samples
Download data: CEL
DataSet
Accession:
GDS3410
ID:
3410
4.

Gene Profiling in the Livers of Wild-Type and PPARalpha-Null Mice Exposed to Perfluorooctanoic Acid (PFOA)

(Submitter supplied) Unlike the PPARalpha agonist W14,643, PFOA is capable of inducing effects independently of PPARa. Genes altered in the PPARalpha-null mouse following exposure to PFOA included those associated with fatty acid metabolism, inflammation, xenobiotic metabolism, and cell cycle progression. The specific signaling pathway(s) responsible for these effects is not readily apparent but it is conceivable that other members of the nuclear receptor superfamily such as PPARbeta/delta and CAR may be involved. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2995
39 Samples
Download data
Series
Accession:
GSE9796
ID:
200009796
5.

Gene expression profiling in the lung and liver of Perfluorooctane sulfonate (PFOS) exposed mouse fetuses

(Submitter supplied) Most of the transcriptional changes induced by PFOS in the fetal mouse liver and lung were related to activation of PPARalpha. When compared to the transcript profiles induced by PFOA (Pubmed ID 17681415), few remarkable differences were found other than up-regulation of Cyp3a genes. Because PFOS and PFOA have been shown to differ in their mode of action in the murine neonate, these data suggest that changes related to PFOS-induced neonatal toxicity may not be evident in the fetal transcriptome at term.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
30 Samples
Download data: CEL
Series
Accession:
GSE13302
ID:
200013302
6.

Orotic acid induced fatty liver disease

(Submitter supplied) A time course of orotic acid induced fatty liver disease. Kyoto and Wistar strain rats were exposed to orotic acid for days 1, 3 and 14. Controls are also included. Keywords = Wistar Keywords = Kyoto Keywords = orotic acid Keywords: time-course
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS765
Platform:
GPL85
14 Samples
Download data
Series
Accession:
GSE665
ID:
200000665
7.
Full record GDS765

Fatty liver disease induced by orotic acid: time course

Expression profiling of livers from inbred Kyotos and outbred Wistars fed a diet with 1% orotic acid to induce fatty liver disease. Profiles examined at various time points up to 14 days. Results used together with NMR spectroscopic analysis of the liver to identify perturbed metabolic pathways.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 2 strain, 4 time sets
Platform:
GPL85
Series:
GSE665
18 Samples
Download data
DataSet
Accession:
GDS765
ID:
765
8.

Expression data from mouse liver

(Submitter supplied) Exposure to high levels of arsenic in drinking water is associated with several types of cancers including lung, bladder and skin, as well as vascular disease and diabetes. Drinking water standards are based primarily on epidemiology and extrapolation from higher dose experiments, rather than measurements of phenotypic changes associated with chronic exposure to levels of arsenic similar to the current standard of 10ppb, and little is known about the difference between arsenic in food as opposed to arsenic in water. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
59 Samples
Download data: CEL, CHP
Series
Accession:
GSE9630
ID:
200009630
9.

Embryo exposure to heat shock and teratogen

(Submitter supplied) Analysis of embryos exposed to either: [1] 40 uM 4-hydroperoxycyclophosphamide for 1 or 5 hours at 37°C [2] 43°C heat shock for 15 minutes followed by 1 or 5 hours at 37°C This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL777 GPL776
112 Samples
Download data
Series
Accession:
GSE905
ID:
200000905
10.

Effect of TCPOBOP and PCN in combination with high-cholesterol diet on genes involved in cholesterol homeostasis

(Submitter supplied) TCPOBOP (1,4-bis[2-(3,5-dichloropyridyloxy)]benzene) and PCN (pregnenolone 16α-carbonitrile) are inducers of drug metabolism through activation of nuclear receptors CAR (constitutive androstane receptor) and PXR (pregnane X receptor), respectively. Mouse experiment was designed to study the effect of CAR and PXR activation on cholesterol homeostasis genes and other genes, which are present on the Steroltalk v2 microarray. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7190
42 Samples
Download data: TAB, TXT
Series
Accession:
GSE13688
ID:
200013688
11.

Exposure of pregnant mice to carbon black by intratracheal instillation: toxicogenomics effects in dams and offspring

(Submitter supplied) Exposure to nanomaterials (NM) during sensitive stages of development may predispose organisms to diseases later in life. However, direct translocation of NM from mother to fetus through the placenta is limited. The present study tests the hypothesis that pulmonary exposure to NM and NM-induced stress, such as inflammation during gestation, can lead to secondary effects in the growing fetus. Time mated C57BL/6BomTac mice were exposed by intratracheal instillation to vehicle (Milli Q water) or one of three concentrations (2.75, 13.5 or 67 µg/animal) of carbon black Printex 90 (CB) dispersions on gestational days 7, 10, 15 and 18 to a total final dose of 11, 54 or 268 µg/animal. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
38 Samples
Download data: TXT
Series
Accession:
GSE29764
ID:
200029764
12.

Exposure of pregnant mice to carbon black by intratracheal instillation: toxicogenomics effects in dams and offspring (offspring samples)

(Submitter supplied) Exposure to nanomaterials (NM) during sensitive stages of development may predispose organisms to diseases later in life. However, direct translocation of NM from mother to fetus through the placenta is limited. The present study tests the hypothesis that pulmonary exposure to NM and NM-induced stress, such as inflammation during gestation, can lead to secondary effects in the growing fetus. Time mated C57BL/6BomTac mice were exposed by intratracheal instillation to vehicle (Milli Q water) or one of three concentrations (2.75, 13.5 or 67 µg/animal) of carbon black Printex 90 (CB) dispersions on gestational days 7, 10, 15 and 18 to a total final dose of 11, 54 or 268 µg/animal. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
18 Samples
Download data: TXT
Series
Accession:
GSE29762
ID:
200029762
13.

Exposure of pregnant mice to carbon black by intratracheal instillation: toxicogenomics effects in dams and offspring (dams samples)

(Submitter supplied) Exposure to nanomaterials (NM) during sensitive stages of development may predispose organisms to diseases later in life. However, direct translocation of NM from mother to fetus through the placenta is limited. The present study tests the hypothesis that pulmonary exposure to NM and NM-induced stress, such as inflammation during gestation, can lead to secondary effects in the growing fetus. Time mated C57BL/6BomTac mice were exposed by intratracheal instillation to vehicle (Milli Q water) or one of three concentrations (2.75, 13.5 or 67 µg/animal) of carbon black Printex 90 (CB) dispersions on gestational days 7, 10, 15 and 18 to a total final dose of 11, 54 or 268 µg/animal. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
20 Samples
Download data: TXT
Series
Accession:
GSE29761
ID:
200029761
14.

Burn20

(Submitter supplied) Type of experiment: Comparison of liver samples between sham (control) and 20% TBSA (total burn surface area) burn rats collected at 1h, 4h, 8h, and 24h. Experimental factors: Burn injury and time Experiment design: All experimental liver samples collected after 1h, 4h, 8h, and 24h after burn injury were compared to a common reference (sham control treated as 0h time point) Bio source: Sprague-Drawley male rats weighing 150-200 g supplied through Charles river laboratories, MA (www.criver.com) Bio material manipulations: Rats (n=3 for each scald-burn and sham-burn time point) were individually housed in a temperature-controlled (25oC) and light-controlled room (12h light-dark cycle) and allowed to adjust to their new surroundings for at least 5 days prior to the experiment. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS599
Platform:
GPL85
10 Samples
Download data
Series
Accession:
GSE802
ID:
200000802
15.
Full record GDS599

Burn injury: liver metabolic and inflammatory response

Temporal analysis of metabolic and inflammatory response to burn injury. Livers from male Sprague-Dawleys examined at 1, 4, 8, and 24 hours following 20% total burn surface area scald-burn injury.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 5 time sets
Platform:
GPL85
Series:
GSE802
10 Samples
Download data
16.

Murine Müllrian duct Day0 DES

(Submitter supplied) Diethylstilbestrol (DES) inhibits the differentiation of female reproductive tracts during fetal and neonatal days . We examined global gene expressions in the oviduct, uterus and vagina in newborn mice with or without DES. These results suggest understanding the mechanism of the differentiation of female reproductive tracts. Keywords: ordered
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL339 GPL81
18 Samples
Download data: CEL, EXP, RPT, TXT
Series
Accession:
GSE1886
ID:
200001886
17.

The effects of subchronic arsenate exposure on gene expression in the mouse lung

(Submitter supplied) Eight week old female C57BL/6 mice were exposed to arsenate in drinking water (50 ppm) for a period of twelve weeks (n = 5). Control animals received distilled deionized water (n = 5). Lung tissue was dissected and used for RNA isolation and gene expression microarray analysis.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4914
Platform:
GPL1261
10 Samples
Download data: CEL
Series
Accession:
GSE21193
ID:
200021193
18.
Full record GDS4914

Lung response to arsenate

Analysis of lungs of females exposed to 50 ppm arsenate (As) for 90 days. Results compared with those from bisulfite sequencing in order to provide insight into the molecular mechanisms underlying the toxicological effects of As.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL1261
Series:
GSE21193
10 Samples
Download data: CEL
DataSet
Accession:
GDS4914
ID:
4914
19.

Expression data from wild-type and PPARalpha-null mice exposed to perfluorooctane sulfonate (PFOS)

(Submitter supplied) Perfluorooctane sulfonate (PFOS) is a perfluoroalkyl acid (PFAA) and a persistent environmental contaminant found in the tissues of humans and wildlife. Although blood levels of PFOS have begun to decline, health concerns remain because of the long half-life of PFOS in humans. Like other PFAAs, such as perfluorooctanoic acid (PFOA), PFOS is an activator of peroxisome proliferator-activated receptor-alpha (PPARα) and exhibits hepatocarcinogenic potential in rodents. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
30 Samples
Download data: CEL
Series
Accession:
GSE22871
ID:
200022871
20.

Human fetal penile smooth muscle cells (hfPSCM): Control vs PCB mixtures treatments

(Submitter supplied) The effects exerted by three mixtures of Polychlorinated Biphenyls (PCB), one featuring dioxin-like (DL) and two featuring non dioxin-like (NDL) congeners, on human fetal corpora cavernosa cells representative of a major male endocrine-sensitive organ, have been evaluated by gene expression profiling. PCB congeners concentrations used were derived from human internal exposure data to explore the impact of the adult body burden on a fetal tissue. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
16 Samples
Download data: TXT
Series
Accession:
GSE25193
ID:
200025193
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