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Links from GEO DataSets

Items: 5

1.
Full record GDS3431

Non-alcoholic steatohepatitis model

Analysis of livers from males fed a high polyunsaturated diet containing 70% corn oil to induce the development of non-alcoholic steatohepatitis (NASH). In NASH, steatosis is accompanied by inflammation, necrosis, apoptosis, and fibrosis. Results provide insight into the pathogenesis of NASH.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL85
Series:
GSE8253
6 Samples
Download data: CEL, CHP, EXP
DataSet
Accession:
GDS3431
ID:
3431
2.

Non-alcoholic Steatohepatitis following feeding of high polyunsaturated fat diets

(Submitter supplied) Most commonly used models of non-alcoholic steatohepatitis (NASH) are diets based on specific gene knockouts or represent extreme manipulations of diet. We have examined the effects of modest increased caloric intake and high dietary unsaturated fat content on the development of NASH in male rats using a model in which overfeeding is accomplished via intragastric infusion of liquid diets as a part of total enteral nutrition. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3431
Platform:
GPL85
6 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE8253
ID:
200008253
3.

Effect of Concentration and type of Dietary Fatty Acid on Development of Nonalcoholic Fatty Liver Disease

(Submitter supplied) The current study was designed to determine if dietary fatty acid concentration and composition affects the development and progression of nonalcoholic fatty liver disease. Male SD rats were overfed diets low (5%) or high (70%) fat diets via total enteral nutrition where the fat source was olive oil (monounsaturated), or corn oil (polyunsaturated). Overfeeding 5% corn oil produced little steatosis relative to feeding 5% olive oil. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL85
12 Samples
Download data: CEL
Series
Accession:
GSE33166
ID:
200033166
4.

Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice

(Submitter supplied) To determine the effect of consumption of a quercetin-rich diet on obesity and dysregulated hepatic gene expression, C56BL/6J mice were fed for 20 weeks on control or a Western diet high in fat, cholesterol and sucrose, both with or without 0.05% quercetin. Chronic dietary intake of quercetin reduced body weight gain and visceral and liver fat accumulation, and improved hyperglyceamia, hyperinsulinaemia, dyslipidaemia in mice fed a Western-style diet. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
18 Samples
Download data: CEL, CHP
Series
Accession:
GSE38141
ID:
200038141
5.

Isocaloric intake of diets differing in macronutrient content (high protein or high fat) in adult rats indicate adverse effects as analysed by hepatic transcriptomics

(Submitter supplied) Intake of high-protein (HP) diets has increased over the last years, mainly due to their popularity for body weight control. Liver is the main organ handling ingested macronutrients and it is associated with the beginning of different pathologies. We aimed to deepen our knowledge on molecular pathways affected by long-term intake of an HP diet. We performed a transcriptome analysis on liver of rats chronically fed with a casein-rich HP diet and analyzed molecular parameters related to liver injury. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL4135
19 Samples
Download data: TXT
Series
Accession:
GSE57858
ID:
200057858
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