GEO DataSets

Analysis of MLP-29 liver cells bearing the heterozygous Kras G12D mutation. KRAS mutations are present at a high frequency in human cancers. Results identify a gene expression signature for the presence of the mutated Kras.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL4865

Series:

GSE8711

4 Samples

Download data

(Submitter supplied) KRAS mutations are present at a high frequency in human cancers. The development of therapies targeting mutated KRAS requires cellular and animal preclinical models. We exploited adeno-associated virus-mediated homologous recombination to insert the KRAS G12D allele in the genome of mouse somatic cells. Heterozygous mutant cells displayed a constitutively active Kras protein, marked morphologic changes, increased proliferation and motility but were not transformed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3455 GDS3456

Platforms:

GPL4865 GPL8321

12 Samples

Download data: CEL

Analysis of MLP-29 liver cells bearing the heterozygous Kras G12D mutation. KRAS mutations are present at a high frequency in human cancers. Results identify a gene expression signature for the presence of the mutated Kras.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL8321

Series:

GSE8711

8 Samples

Download data: CEL

(Submitter supplied) We compared the transformation efficiencies of mutant NRAS and KRAS in immortal, non-transformed Ink4a/Arf-deficient melanocytes. NRAS mutation leads to increased cellular proliferation and is potently tumorigenic. In contrast, KRAS mutation does not enhance melanocyte proliferation and is only weakly tumorigenic on its own. While both NRAS and KRAS activate MAPK signaling, only NRAS enhances MYC activity in these cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4487

12 Samples

Download data: GPR

(Submitter supplied) Mouse lung cancers were generated using the KrasLA model, in which a latent mutated Kras2 allele (resulting in the amino acid substitution G12D) is sporadically activated through spontaneous homologous recombination. These mice develop lung adenomas with full penetrance; over time, the tumors acquire morphologic characteristics reminiscent of those of human adenocarcinoma, such as nuclear atypia and a high mitotic index. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

50 Samples

Download data: CEL

(Submitter supplied) Gene expression and Comparative genomic hybridization (CGH) microarrays performed in a set of 8 Lung cancer Cell lines.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by array

Platform:

GPL1998

16 Samples

Download data: GPR

(Submitter supplied) Microarray expression data generated to compare the biological impact of KrasG12D allelic duplication in p53null mouse embryonic fibroblasts (MEFs). The RAS/MAPK-signalling pathway is frequently deregulated in non-small cell lung cancer (NSCLC), often through activating mutations in KRAS. Mouse models demonstrated that activation of a single endogenous mutant Kras allele is sufficient to promote lung tumour formation, but acquisition of other genetic alterations is required for malignant progression. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

6 Samples

Download data: TXT

(Submitter supplied) We generated RNAseq profiles from Small Airway Epithelial Cells (SALE) expressing either KRAS G12V or GFP control.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

10 Samples

Download data: TXT

(Submitter supplied) We sequenced mRNA from HCC44 and YAPC cell lines stably expressing Cas9, and infecting with indicated gRNAs against regulators of KRAS transcriptional components.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

21 Samples

Download data: GCT