GEO DataSets

Analysis of the gastrointestinal tracts of animals up to 72 hours following treatment with the chemotherapy agent irinotecan to induce gastrointestinal mucositis (GM). GM is caused by the cytotoxic effects of cancer chemotherapy and radiotherapy. Results provide insight into the pathogenesis of GM.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 5 time, 3 tissue sets

Platform:

GPL1355

Series:

GSE11722

30 Samples

Download data: CEL

(Submitter supplied) The regional specificity and timing of gene activation following chemotherapy, and how this relates to subsequent mucositis development is currently unknown. The aim of the study was therefore to determine the early time course of gene expression changes along the gastrointestinal tract (GIT) of the DA rat following irinotecan treatment, so as to provide an insight into the genetic component of mucositis. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3466

Platform:

GPL1355

30 Samples

Download data: CEL

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL16027

72 Samples

Download data: TXT

(Submitter supplied) This is an experiment to study the effects of total body irradiation on intestinal gene expression. There are 24 male animals in the study; 4 controls, 10 animals received 6.7 Gy, 10 received 7.4 Gy. Animals were killed 4, 7 or 12 days after irradiation

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL16027

24 Samples

Download data: TXT

(Submitter supplied) This is an experiment to study the effects of total body irradiation on intestinal gene expression. There are 24 male animals in the study; 4 controls, 10 animals received 6.7 Gy, 10 received 7.4 Gy. Animals were killed 4, 7 or 12 days after irradiation

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL16027

24 Samples

Download data: TXT

(Submitter supplied) This is an experiment to study the effects of total body irradiation on intestinal gene expression. There are 24 male animals in the study; 4 controls, 10 animals received 6.7 Gy, 10 received 7.4 Gy. Animals were killed 4, 7 or 12 days after irradiation

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL16027

24 Samples

Download data: TXT

(Submitter supplied) Whole tissues corresponding to the corpus, jejunum, descending colon and rectum were dissected from each mouse, washed with ice-cold PBS, placed into 2ml of RNA-later and flash-frozen in liquid nitrogen. The corpus was defined as the part of the stomach different from the antrum (distinguished by a difference in colour). The jejunum was defined as the tissue between the first 4 cm and the last 2 cm of the small intestinal tube. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS640

Platform:

GPL81

24 Samples

Download data

Analysis of germ-free and conventional corpus, jejunum, descending colon and rectum. Findings identify important interaction between commensal microbiota and gastrointestinal tract transcriptome.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 other, 4 tissue sets

Platform:

GPL81

Series:

GSE1392

24 Samples

Download data

(Submitter supplied) Background and aims: Dysregulation of intestinal epithelial cells performance associates with an array of pathologies whose onset mechanisms are incompletely understood. The aim of the present study was to provide a map of gene expresssion patterns along the human healthy adult gastro-intestinal tract and to implement a new procedure for microarray data noise filtering that would allow their use as a reference when screening for pathological deviations, such as inflammatory bowel disease (IBD). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

20 Samples

Download data: CEL, CHP