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Links from GEO DataSets

Items: 20

1.
Full record GDS3496

Alveolar macrophages of cigarette smokers

Analysis of alveolar macrophages from cigarette smokers. Cigarette smoking is associated with increased lung cell turnover. Mononuclear phagocytes, such as macrophages, play an important role in the removal of apoptotic cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 other sets
Platform:
GPL570
Series:
GSE8823
24 Samples
Download data: CEL, CHP
2.

Overexpression of the Apoptotic Cell Removal Receptor, MERTK, in Alveolar Macrophages of Cigarette Smokers

(Submitter supplied) Mononuclear phagocytes play an important role in the removal of apoptotic cells by expressing cell surface receptors that recognize and remove apoptotic cells. Based on the knowledge that cigarette smoking is associated with increased lung cell turnover, we hypothesized that alveolar macrophages (AM) of normal cigarette smokers may exhibit enhanced expression of apoptotic cell removal receptor genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3496
Platform:
GPL570
24 Samples
Download data: CEL, CHP
Series
Accession:
GSE8823
ID:
200008823
3.

Smoking-dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of COPD

(Submitter supplied) Background: When exposed to specific stimuli, macrophages exhibit distinct activation programs, M1 and M2 polarization, that define macrophage function as inflammatory/immune effectors or anti-inflammatory/tissue remodeling cells, respectively. Due to their position on the lung epithelial surface, alveolar macrophages (AM) directly interact with environmental stimuli such as cigarette smoke, the major risk factor for the development of chronic obstructive pulmonary disease (COPD). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
70 Samples
Download data: CEL, CHP
Series
Accession:
GSE13896
ID:
200013896
4.

Cell origin dictates programming of resident versus recruited macrophages during acute lung injury

(Submitter supplied) The primary objective of this study was to compare global differences in transcriptional programming of resident and recruited alveolar macrophages in a time-limited murine model of lung inflammation. We first performed RNA sequencing of the resident and recruited alveolar macrophages from initiation through resolution of LPS-induced lung inflammation in the mouse. Our results indicate that despite existing in a shared environment, cell origin is the major determinant of programming of resident and recruited AMs during an acute inflammatory response. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18635
27 Samples
Download data: TXT
Series
Accession:
GSE94749
ID:
200094749
5.

Upregulation of Expression of Matrix Metalloproteinases in Alveolar Macrophages of HIV1+ Smokers with Early Emphysema

(Submitter supplied) HIV1+ smokers develop emphysema at an earlier age and with a higher incidence than HIV1- smokers. Based on the knowledge that human alveolar macrophages (AM) are capable of producing proteases that degrade extracellular matrix components, we hypothesized that upregulation of AM matrix metalloproteinases may be associated with the emphysema of HIV1+ smokers. To test this hypothesis, microarray analysis was used to screen which MMP genes were expressed by AM isolated by bronchoalveolar lavage (BAL) of HIV1+ smokers with early emphysema. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
11 Samples
Download data: CEL, CHP
Series
Accession:
GSE10038
ID:
200010038
6.

Disparate Oxidant-related Gene Expression of Human Small Airway Epithelium Compared to Autologous Alveolar Macrophages

(Submitter supplied) Disparate Oxidant-related Gene Expression of Human Small Airway Epithelium Compared to Autologous Alveolar Macrophages in Response to the In Vivo Oxidant Stress of Cigarette Smoking The oxidant burden of cigarette smoking induces lung cell dysfunction, and play a significant role in the pathogenesis of lung disease. Two cell populations directly exposed to the oxidants in cigarette smoke are the small airway epithelium and alveolar macrophages. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
98 Samples
Download data: CEL, CHP
Series
Accession:
GSE13931
ID:
200013931
7.

Airway epithelium, large and small airways, phenotypically normal smokers, non-smokers, early COPD and COPD

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL96 GPL80 GPL570
124 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE5060
ID:
200005060
8.

Airway epithelium, large airways, phenotypically normal smokers vs non-smokers, MAS5 (HG-U133 2.0)

(Submitter supplied) Upregulation of Expression of the Ubiquitin Carboxyl Terminal Hydrolase L1 Gene in Human Airway Epithelium of Cigarette Smokers The microarray data deposited here is from 9 HG-U133 Plus 2.0 GeneChips, from 4 normal non-smokers, and 5 phenotypic normal smokers, all large airways. These data are part of a study aimed at understanding how cigarette smoking modifies neuroendocrine cells, in which microarray analysis with TaqMan confirmation was used to assess airway epithelial samples obtained by fiberoptic bronchoscopy from 81 individuals (normal nonsmokers, normal smokers, smokers with early COPD and smokers with established COPD). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2491
Platform:
GPL570
9 Samples
Download data
Series
Accession:
GSE5059
ID:
200005059
9.

Airway epithelium, small airways, normal non-smokers, phenotypic normal smokers, smokers with COPD and early COPD

(Submitter supplied) Upregulation of Expression of the Ubiquitin Carboxyl Terminal Hydrolase L1 Gene in Human Airway Epithelium of Cigarette Smokers The microarray data deposited here is from 39 HG-U133 Plus 2.0 GeneChips, from 12 normal non-smokers, 12 phenotypic normal smokers, 9 Early COPD and 6 COPD individuals, all small airways, all small airway. A subset of these samples have been already submitted under GEO Accession Number GSE 4498. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
39 Samples
Download data: CEL, CHP
Series
Accession:
GSE5058
ID:
200005058
10.

Airway epithelium, large airways, phenotypically normal smokers vs non-smokers, MAS5 (HG-U133A)

(Submitter supplied) Upregulation of Expression of the Ubiquitin Carboxyl Terminal Hydrolase L1 Gene in Human Airway Epithelium of Cigarette Smokers The microarray data deposited here is from 11 HG-U133A GeneChips, from 5 normal non-smokers and 6 phenotypic normal smokers, large airways. Samples from the small airways of these individuals have been obtained and analyzed using the HG-U133A GeneChip; the small airway samples are in GEO Accession Number GSE 3320, and the data analysis is described in Harvey, B-G; Heguy, A.; Leopold, P.L.; Carolan, B.; Ferris, B. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2490
Platform:
GPL96
11 Samples
Download data
Series
Accession:
GSE5057
ID:
200005057
11.

Airway epithelium, large airways, phenotypically normal smokers vs non-smokers, MAS5 (HuGeneFL)

(Submitter supplied) Upregulation of Expression of the Ubiquitin Carboxyl Terminal Hydrolase L1 Gene in Human Airway Epithelium of Cigarette Smokers The microarray data deposited here is from 44 HuGeneFL GeneChips, from 9 normal non-smokers and 13 phenotypic normal smokers, large airways, 2 samples per individual, one from the right lung and one from the left lung. These samples were previously described in Hackett NR, Heguy A, Harvey BG, O'Connor TP, Luettich K, Flieder DB, Kaplan R, Crystal RG. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2489
Platform:
GPL80
44 Samples
Download data
Series
Accession:
GSE5056
ID:
200005056
12.
Full record GDS2491

Large airway epithelium response to cigarette smoking (HG-U133 2.0)

Analysis of large airway epithelial cells of phenotypically normal smokers. Lung cancer tumors exhibit neuroendocrine properties, and chronic smokers have increased numbers of neuroendocrine cells. Results provide insight into the effect of cigarette smoking on neuroendocrine cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 stress sets
Platform:
GPL570
Series:
GSE5059
9 Samples
Download data
DataSet
Accession:
GDS2491
ID:
2491
13.
Full record GDS2490

Large airway epithelium response to cigarette smoking (HG-133A)

Analysis of large airway epithelial cells of phenotypically normal smokers. Lung cancer tumors exhibit neuroendocrine properties, and chronic smokers have increased numbers of neuroendocrine cells. Results provide insight into the effect of cigarette smoking on neuroendocrine cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 stress sets
Platform:
GPL96
Series:
GSE5057
11 Samples
Download data
DataSet
Accession:
GDS2490
ID:
2490
14.
Full record GDS2489

Large airway epithelium response to cigarette smoking (HuGeneFL)

Analysis of large airway epithelial cells of phenotypically normal smokers. Lung cancer tumors exhibit neuroendocrine properties, and chronic smokers have increased numbers of neuroendocrine cells. Results provide insight into the effect of cigarette smoking on neuroendocrine cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 stress sets
Platform:
GPL80
Series:
GSE5056
44 Samples
Download data
DataSet
Accession:
GDS2489
ID:
2489
15.

Decreased Expression of Intelectin 1 in The Human Airway Epithelium of Smokers Compared to Nonsmokers

(Submitter supplied) Lectins are proteins present on cell surfaces or as shed extracellular proteins that function in innate immune defense as phagocytic receptors to recognize specific bacterial cell wall components. Based on the knowledge that cigarette smoking is associated with increased risk of bacterial infection, we hypothesized that cigarette smoking may modulate the expression of lectin genes in the airway epithelium. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
87 Samples
Download data: CEL, CHP
Series
Accession:
GSE10006
ID:
200010006
16.

Genes Associated with MUC5AC Expression in the Human Airway Epithelium

(Submitter supplied) To help define the genes associated with mucus synthesis and secretion in the human small airway epithelium, we hypothesized that comparison of the transcriptomes of the small airway epithelium of individuals that express high vs low levels of MUC5AC, a major secretory mucin and the major component of airway mucus, could be used as a probe to identify the genes related to human small airway mucus production / secretion. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
132 Samples
Download data: CEL, CHP, TXT
Series
Accession:
GSE34450
ID:
200034450
17.

Cigarette Smoking Induces Overexpression of a Fat Depleting Gene AZGP1 in the Human Airway Epithelium

(Submitter supplied) Smokers weigh less and have less body fat than non-smokers, and increased body fat and weight gain are observed following smoking cessation. To assess a possible molecular mechanism underlying the inverse association between smoking and body weight, we hypothesized that smoking may induce the expression of a fat depleting gene in the airway epithelium, the cell population that takes the brunt of the stress of cigarette smoke. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL80 GPL570 GPL96
92 Samples
Download data: CEL, CHP
Series
Accession:
GSE10135
ID:
200010135
18.

Expression data from polarized adult human microglia and macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
30 Samples
Download data: CEL, CHP
Series
Accession:
GSE76737
ID:
200076737
19.

Expression data from polarized adult human macrophages

(Submitter supplied) Myeloid cells are prominent cellular constituents of the CNS. Under physiologic conditions, these include microglia within the parenchyma and systemic compartment derived macrophages localized to the perivascular spaces. Defining the relative distribution and functions of microglia versus blood-derived macrophages in the CNS parenchyma under pathologic conditions remains a challenge due to limitations in being able to distinguish these cell types. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
15 Samples
Download data: CEL, CHP
Series
Accession:
GSE76736
ID:
200076736
20.

Expression data from polarized adult human microglia

(Submitter supplied) Myeloid cells are prominent cellular constituents of the CNS. Under physiologic conditions, these include microglia within the parenchyma and systemic compartment derived macrophages localized to the perivascular spaces. Defining the relative distribution and functions of microglia versus blood-derived macrophages in the CNS parenchyma under pathologic conditions remains a challenge due to limitations in being able to distinguish these cell types. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
15 Samples
Download data: CEL, CHP
Series
Accession:
GSE76734
ID:
200076734
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