GEO DataSets

Analysis of cultured monocytes following TREM-1 activation by treatment with an antibody against TREM-1. TREM-1 is an immunoreceptor expressed on monocytes, macrophages, and neutrophils. Results provide insight into the cellular consequences of TREM-1 activation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 6 agent, 11 individual sets

Platform:

GPL570

Series:

GSE9988

62 Samples

Download data: CEL

(Submitter supplied) TREM-1 is an orphan immunoreceptor expressed on monocytes, macrophages, and neutrophils. TREM-1 associates with and signals via the adapter protein DAP12/TYROBP, which contains an immunoreceptor tyrosine-based activation motif (ITAM). TREM-1 activation by receptor cross-linking is pro-inflammatory, and can amplify cellular responses to Toll-like receptor (TLR) ligands such as bacterial lipopolysaccharide (LPS). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3499

Platform:

GPL570

62 Samples

Download data: CEL

(Submitter supplied) LPS plus ISO and LPS plus PGE2 had non-additive effects on gene expression in RAW 264.7 cells Keywords: time course

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL254

88 Samples

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(Submitter supplied) LPS plus IFG and LPS plus 2MA had non-additive effects on gene expression in RAW 264.7 cells Keywords: time course

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL254

90 Samples

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(Submitter supplied) All samples were gathered from mouse RAW 264.7 cells (macrophages). Control total RNA was extracted from untreated RAW 264.7 cells cultured for either 1, 2, 4, 8, 16 or 48 hours. Test total RNA was extracted from lipopolysaccharide (100ng/ml) and lipopolysaccharide-binding protein (100pM) treated RAW 264.4 cells cultured for either 1, 2, 4, 8, 16 or 48 hours. This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL254

36 Samples

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(Submitter supplied) Paeony root has long been used for its anti-inflammatory effects. In this study, the effects of albiflorin, paeoniflorin, and paeonol, compounds from paeony root, on gene expression profiles were examined in macrophages. The RAW264.7 macrophages were treated with LPS in the presence or absence of albiflorin, paeoniflorin, or paeonol. Global mRNA expression levels were detected by using an oligonucleotide microarray platform covering the mouse whole genome. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2995

33 Samples

Download data: TXT

(Submitter supplied) Dendritic cells (DCs) are professional antigen-presenting cells whose activity is intrinsically linked to the microenvironment. Hypoxia is a condition of low oxygen tension occurring in inflammatory tissues that creates a special microenvironment conditioning cell physiology. We studied the effects of hypoxia on the differentiation of human monocytes into DCs and maturation into mature DCs. Mature DCs were differentiated in vitro from human monocytes under normoxic or hypoxic conditions and the gene expression profile was determined. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3858

Platform:

GPL570

6 Samples

Download data: CEL, CHP

Analysis of mature dendritic cells (mDC) generated from monocytes under chronic hypoxia (1%O2). Hypoxia is a common feature at pathologic sites that creates a unique microenvironment affecting cell phenotype and behavior. Results provide insight into the impact of chronic hypoxia on mDC development.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL570

Series:

GSE22282

6 Samples

Download data: CEL, CHP