GEO DataSets

Analysis of H295R adrenocortical carcinoma cells treated with the hydroxylated polybrominated biphenyl ether (PBDE) 2-OH-BDE47 or 2-OH-BDE85. PBDEs are used as flame retardants in various products. The two PBDEs are cytotoxic. Results provide insight into the molecular basis of PBDE cytotoxicity.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL570

Series:

GSE8588

9 Samples

Download data: CEL

(Submitter supplied) Polybrominated diphenyl ethers (PBDEs) are commonly used as flame retardants in a variety of commercial and household products. They have been detected in the environment and accumulate in mammalian tissues and fluids. PBDE toxicity is thought to be associated with endocrine disruption, developmental neurotoxicity and changes in fetal development. Although humans are exposed to PBDEs, our knowledge of the effects of PBDE metabolites on human cells with respect to health risk is insufficient. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3537

Platform:

GPL570

9 Samples

Download data: CEL

(Submitter supplied) Transcriptional profiling of human adrenocortical tumors. Gene expression profile of normal adrenal cortex, hormonally inactive adenoma, cortisol-secreting Cushing-adenoma and primary adrenocortical cancer tissues were compared. The goal of this study was to identify significant differences in the gene expression of these groups. Further aim was to reveal biologically relevant pathogenetic pathways altered at transcriptional and posttranscriptional level, as well.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

16 Samples

Download data: TXT

(Submitter supplied) Pediatric adrenocortical tumors (ACT) are rare and often fatal malignancies; little is known regarding their etiology and biology. To provide additional insight into the nature of ACT, we determined the gene expression profiles of 24 pediatric tumors (five adenomas, 18 carcinomas, and one undetermined) and seven normal adrenal glands. Distinct patterns of gene expression, validated by quantitative real-time PCR and Western blot analysis, were identified that distinguish normal adrenal cortex from tumor. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

31 Samples

Download data: CEL