Similar studies for GEO DataSets (Select 3556) - GEO DataSets

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Items: 3

Select item 35561.

Torcetrapib effect on adrenal carcinoma cell line

Analysis of H295 adrenal carcinoma cells treated with torcetrapib, an anti-cholesterol drug. Adverse side effects of torcetrapib treatment include changes in blood pressure, potassium, sodium, and aldosterone. Results provide insight into the molecular basis of the off-target side effects.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 agent sets

Platform:: GPL570
Series:: GSE15918
9 Samples

Download data: CEL

DataSet

Accession:: GDS3556

ID:: 3556

Select item 2000159182.

Torcetrapib induces aldosterone and cortisol production in an intracellular calcium-dependent mechanism

(Submitter supplied) ILLUMINATE (Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events), the phase 3 morbidity and mortality trial of torcetrapib, a cholesteryl ester transfer protein (CETP) inhibitor, identified previously undescribed changes in plasma levels of potassium, sodium, bicarbonate, and aldosterone. A key question after this trial is whether the failure of torcetrapib was a result of CETP inhibition or of some other pharmacology of the molecule. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3556
Platform:: GPL570
9 Samples

Download data: CEL

Series

Accession:: GSE15918

ID:: 200015918

Select item 2000055533.

H295R human adrenocortical cells treated with Angiotensin II, Potassium or Forskolin

(Submitter supplied) H295R human adrenocortical cells were cultured in H295R complete media containing DMEM:F12 (1:1) supplemented with 2% Ultroser G (Biosepra, Villeneuve-la-Garenne, France), ITS-Plus (Discovery Labware, Bedford, MA) and an antibiotic/antimycotic mixture (Invitrogen, Carlsbad, CA) in 175 cm2 flasks until subconfluente. Media was replaced with 40 ml fresh media containing different agents and cultured for 3 h. more...