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Links from GEO DataSets

Items: 10

1.
Full record GDS3608

Liver response to perinatal exposure to 2,2',4,4'-tetrabromodiphenyl ether: dose response

Analysis of livers of animals exposed to low doses of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) from gestational day 15 to post-natal day 20. Polybrominated diphenyl ethers are flame-retardant chemicals used in consumer products. Results provide insight into the mechanisms of toxicity of BDE-47.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 agent, 3 dose sets
Platform:
GPL6101
Series:
GSE19868
18 Samples
Download data
2.

Liver of rat offsprings exposed perinatally to low doses of 2,2',4,4'-tetrabromodiphenyl ether

(Submitter supplied) Background: Polybrominated diphenyl ethers are a group of flame-retardant chemicals appearing increasingly in the environment. Their health effects and mechanisms of toxicity are poorly understood.Objectives: We screened for the sensitive effects and mechanisms of toxicity of 2,2 ,4,4 -tetra-bromodiphenyl ether (BDE-47) by analyzing the gene expression profile in rats exposed to doses comparable to human exposure.Methods: Wistar dams were exposed to vehicle or BDE-47 (0.002 and 0.2 mg/kg body weight) every fifth day from gestation day 15 to postnatal day 20 by injections to caudal vein. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3608
Platform:
GPL6101
18 Samples
Download data: TXT
Series
Accession:
GSE19868
ID:
200019868
3.

Expression data from PBDE treated rats at PND22 and Week 13

(Submitter supplied) Liver gene transcripts patterns were used to characterize toxicity from exposure to polybrominated diphenyl ethers (PBDEs), flame retardant components. In this study, Wistar Han dams were exposed by gavage to the PBDE mixture (DE71) starting at gestation day 6 (GD 6) and continuing to weaning on postnatal day 21 (PND 21). Offspring from the dams began PBDE direct dosing on PND 12 and were dosed daily through PND 21. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS5034
Platform:
GPL1355
30 Samples
Download data: CEL
Series
Accession:
GSE32156
ID:
200032156
4.
Full record GDS5034

Polybrominated diphenyl ether effect on the liver

Analysis of livers collected from postnatal day (PND) 22 and 13-week-old Wistar/Han rats exposed in utero to polybrominated diphenyl ether (PBDE) and directly dosed with PBDE. PBDEs are flame retardants. Results provide insight into the molecular basis of PBDE toxicities.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 age, 2 agent, 2 gender sets
Platform:
GPL1355
Series:
GSE32156
30 Samples
Download data: CEL
5.

Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism

(Submitter supplied) Purpose: The goal of this study was to investigate how PBDEs regulate both PCGs and lncRNAs in a PXR/CAR ligand-dependent and independent manner Methods: HepaRG cells, which are human-derived hepatic cells that accurately represent gene expression profiles of human liver tissue, were exposed to BDE-47 and BDE-99 at a dose of 25 μM for 24 hours. Differentially expressed lncRNA-PCG pairs were identified through DESeq2 and HOMER; significant canonical pathways were determined through Ingenuity Pathway Analysis (IPA). more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL16791
13 Samples
Download data: CSV
Series
Accession:
GSE143260
ID:
200143260
6.

Environmentally relevant concentrations of the flame retardant BDE-209 in sediment cause minimal effects on Zebrafish embryos.

(Submitter supplied) Polychlorinated diphenyl ethers are lipophilic, persistent, and bioaccumulable compounds widely used as flame-retardants. These are chemicals of increasing environmental concern due to their lipophilic, persistent, and bioaccumulable characteristics. The objective of this study was to analyze the potential bioavailability and bioaccumulation of BDE-209 as a source of toxicity. Zebrafish embryos were exposed for 8 days to sediments spiked with an environmentally relevant concentration of BDE-209. more...
Organism:
Danio rerio
Type:
Expression profiling by array
Platform:
GPL6457
8 Samples
Download data: TXT
Series
Accession:
GSE39169
ID:
200039169
7.

Polybrominated diphenyl ethers (PBDEs)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
24 Samples
Download data
Series
Accession:
GSE119588
ID:
200119588
8.

Effects of Polybrominated Diphenyl Ether (PBDE) Mixture on estrogen receptor positive (ER+) patient-derived tumor xenograft (PDX) model

(Submitter supplied) ER+ PDX (COH-SC31) were exposed to PBDE mixture for 1 weeks. RNA-sequencing analysis was performed to evalaute the gene expression changes.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TXT
Series
Accession:
GSE119587
ID:
200119587
9.

Effect of Polybrominated diphenyl ethers (PBDEs) on gene expression of MCF7 cells

(Submitter supplied) RNA sequence analysis showed that PBDE47 had estrogenic activity through cell cycle regulation, and PBDE100 and PBDE153 had anti-estrogenic activity throguth ER and AhR cross talk.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
18 Samples
Download data: TXT
Series
Accession:
GSE111203
ID:
200111203
10.

Novel Interactions between Gut Microbiome and Host Drug-processing Genes Modify the Hepatic Metabolism of the Environmental Chemicals PBDEs

(Submitter supplied) Purpose: Next-generation sequencing (NGS) has been utilized for systems-based analysis of all liver samples. The goals of this study were to compare the hepatic transcriptome and PBDE metabolism between conventional (CV) and germ-free (GF) mice. Methods: Livers from vehicle (corn oil), BDE-47, or BDE-99 treated adult male CV and GF mice were used for RNA-Seq (biological replicates: n=3 for CV corn oil, n=4 for CV BDE-47, n=2 for CV BDE-99, n=3 for GF corn oil, n=3 for GF BDE-47, and n=3 for BDE-99) using a HiSeq 2000 sequencer. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
18 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE101650
ID:
200101650
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