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Links from GEO DataSets

Items: 18

1.
Full record GDS3621

Huntington disease model: brain striatum (Ref-6 V1)

Analysis of brain striata from YAC128 trangenic animals at 12 and 24 months of age. The YAC128 transgenic animal is a model for Huntington disease (HD). Results provide insight into the pathogenesis of HD.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 genotype/variation sets
Platform:
GPL6333
Series:
GSE19677
18 Samples
Download data
2.

Striatum of Huntington's disease model mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS3620 GDS3621
Platforms:
GPL6333 GPL1261
36 Samples
Download data: CEL
Series
Accession:
GSE19677
ID:
200019677
3.

Striatum of Huntington's disease model mice [Illumina data]

(Submitter supplied) Evaluation of transcriptional changes in the striatum may be an effective approach to understanding the natural history of changes in expression contributing to the pathogenesis of Huntington disease (HD). We have performed genome-wide expression profiling of the YAC128 transgenic mouse model of HD at 12 and 24 months of age using two platforms in parallel; Affymetrix and Illumina. We performed gene expression profiling on the same striatal mRNA across both platforms. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6333
18 Samples
Download data: TXT
Series
Accession:
GSE19676
ID:
200019676
4.

Striatum of Huntington's disease model mice [Affymetrix data]

(Submitter supplied) Evaluation of transcriptional changes in the striatum may be an effective approach to understanding the natural history of changes in expression contributing to the pathogenesis of Huntington disease (HD). We have performed genome-wide expression profiling of the YAC128 transgenic mouse model of HD at 12 and 24 months of age using two platforms in parallel; Affymetrix and Illumina. We performed gene expression profiling on the same striatal mRNA across both platforms.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
18 Samples
Download data: CEL
Series
Accession:
GSE18551
ID:
200018551
5.
Full record GDS3620

Huntington disease model: brain striatum (430 2.0)

Analysis of brain striata from YAC128 trangenic animals at 12 and 24 months of age. The YAC128 transgenic animal is a model for Huntington disease (HD). Results provide insight into the pathogenesis of HD.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE19677
18 Samples
Download data: CEL
6.

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

(Submitter supplied) Huntington’s disease (HD), caused by a CAG repeat expansion in the huntingtin (HTT) gene, is characterized by abnormal protein aggregates and motor and cognitive dysfunction. Htt protein is ubiquitously expressed, but the striatal medium spiny neuron (MSN) is most susceptible to neuronal dysfunction and death. Abnormal gene expression represents a core pathogenic feature of HD, but the relative roles of cell-autonomous and non-cell-autonomous effects on transcription remain unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
7 Samples
Download data: TXT
Series
Accession:
GSE25232
ID:
200025232
7.

Elucidating a normal function of huntingtin by analysis of huntingtin-null mouse embryonic fibroblasts

(Submitter supplied) The polyglutamine expansion in huntingtin (Htt) protein is a cause of Huntington’s disease (HD). Htt is an essential gene as deletion of the mouse Htt gene homolog (Hdh) is embryonic lethal in mice. Therefore, in addition to elucidating the mechanisms responsible for polyQ-mediated pathology, it is also important to understand the normal function of Htt protein for both basic biology and for HD. To systematically search for a mouse Htt function, we took advantage of the Hdh +/- and Hdh-floxed mice and generated four mouse embryonic fibroblast (MEF) cells lines which contain a single copy of the Hdh gene (Hdh-HET) and four MEF lines in which the Hdh gene was deleted (Hdh-KO). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6731
12 Samples
Download data: TXT
Series
Accession:
GSE11139
ID:
200011139
8.

Gene Expression Profiling of PGC-1a KO mouse striata

(Submitter supplied) Huntington’s Disease (HD) is an inherited neurodegenerative disease caused by a glutamine repeat expansion in huntingtin protein. Transcriptional deregulation and altered energy metabolism have been implicated in HD pathogenesis. We report here that mutant huntingtin causes disruption of mitochondrial function by inhibiting expression of PGC-1a, a transcriptional coactivator that regulates several metabolic processes including mitochondrial biogenesis and respiration. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2391
Platform:
GPL1261
6 Samples
Download data
Series
Accession:
GSE5786
ID:
200005786
9.
Full record GDS2391

PGC-1alpha transcriptional coactivator null mutation effect on the brain striatum

Analysis of brain striatum of PGC-1alpha transcriptional coactivator null mutants. PGC-1alpha regulates several metabolic processes. Altered energy metabolism is implicated in Huntington's disease (HD). Results provide insight into the role of PGC-1alpha in HD pathogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5786
6 Samples
Download data
DataSet
Accession:
GDS2391
ID:
2391
10.

Human blood expression for Huntington's disease versus control, Codelink

(Submitter supplied) Codelink Human Uniset I, II, and 20K expression levels for 12 symptomatic and 5 presymptomatic Huntington's disease patients versus 14 healthy controls. Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1332
Platform:
GPL1449
31 Samples
Download data
Series
Accession:
GSE1767
ID:
200001767
11.

Human blood expression for Huntington's disease versus control

(Submitter supplied) Affymetrix U133A expression levels for 12 symptomatic and 5 presymptomatic Huntington's disease patients versus 14 healthy controls. Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1331
Platform:
GPL96
31 Samples
Download data
Series
Accession:
GSE1751
ID:
200001751
12.
Full record GDS1332

Huntington's disease: peripheral blood expression profile (Codelink Uniset 20K)

Analysis of blood samples of 5 presymptomatic and 12 symptomatic Huntington's disease (HD) patients. Studies suggest that gene expression may be altered in a variety of tissues in HD, including peripheral blood. Results identify potential markers for HD.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 disease state sets
Platform:
GPL1449
Series:
GSE1767
31 Samples
Download data
13.
Full record GDS1331

Huntington's disease: peripheral blood expression profile (HG-U133A)

Analysis of blood samples of 5 presymptomatic and 12 symptomatic Huntington's disease (HD) patients. Studies suggest that gene expression may be altered in a variety of tissues in HD, including peripheral blood. Results identify potential markers for HD.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 disease state sets
Platform:
GPL96
Series:
GSE1751
31 Samples
Download data
14.

The CNS-Heart Axis is a Source of Cardiac Dysfunction in Mouse Models of Huntington’s Disease

(Submitter supplied) Purpose: Transcriptome profiling (RNA-seq) to microarray to evaluate transcriptional changes in the heart of HD mouse models Methods: Heart mRNA profiles of 4-weeks-old wild-type (WT) and R6/2 transgenic; 15-weeks-old WT and R6/2 transgenic mice; 8-month-old WT and HdhQ150 knock-in mice; 22-month-old WT and HdhQ150 knock-in mice were generated by deep sequencing, in triplicate, using Illumina Hi-seq 2000. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
30 Samples
Download data: TXT
Series
Accession:
GSE58996
ID:
200058996
15.

Microarray gene expression data from Hdh knock-out, wild-type and knock-in embryonic stem cells

(Submitter supplied) Huntington's disease (HD) features a unique disease-initiating mechanism hypothesized to entail an impact of the CAG repeat encoded polyglutamine region on the full-length huntingtin protein, with dominant effects that are continuous with CAG size, in a simple gain of function. To evaluate these predictions, we generated a series of heterozygous Hdh CAG knock-in mouse embryonic stem (ES) cell lines, with 18, 48, 89, 109 CAGs, and found that a continuous analytic strategy efficiently identified, from genome-wide datasets, 73 genes and 172 pathways whose expression varied continuously with CAG length. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4533
Platform:
GPL1261
24 Samples
Download data: CEL
Series
Accession:
GSE26001
ID:
200026001
16.
Full record GDS4533

Huntington's disease Hdh knock-out and knock-in embryonic stem cells

Analysis of embryonic stem cells without Hdh or with knock-in alleles with different Hdh CAG-polyglutamine repeat sizes. CAG-repeat length is inversely correlated with the age of onset of Huntington's disease (HD) symptoms in humans. Results provide insight into molecular mechanisms underlying HD.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 6 cell line, 3 genotype/variation, 7 other sets
Platform:
GPL1261
Series:
GSE26001
24 Samples
Download data: CEL
17.

Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS

(Submitter supplied) Forkhead box protein P1 (Foxp1), a transcription factor showing highly enriched expression in the striatum, has been implicated in CNS development, but its role in the mature brain is unknown. In order to ascertain functional roles for Foxp1 in the CNS, we have identified gene targets for Foxp1 in vitro using gene expression microarrays and chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) assays. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
6 Samples
Download data: TXT
Series
Accession:
GSE31560
ID:
200031560
18.

N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice

(Submitter supplied) Longitudinal microarray data from BACHD-ΔN17 mice with wildtype littermate controls
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
48 Samples
Download data: TXT
Series
Accession:
GSE64386
ID:
200064386
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