GEO DataSets

Analysis of liver from ob/ob animals treated with 12.5 or 25 ng/hour of leptin. Treatment of ob/ob animals with 12.5 ng/hour of leptin lowers blood glucose and that with 25 ng/hour normalizes plasma glucose and insulin without reducing body weight.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 dose sets

Platform:

GPL6885

Series:

GSE19185

8 Samples

Download data

(Submitter supplied) Ob/ob mice were given 0, 12.5 or 25 ng/hr leptin through an osmotic pump. After 12 days, livers RNA was prepared and illumina microarrays were done. We tested whether leptin can ameliorate diabetes independent of weight loss by defining the lowest dose at which leptin treatment of ob/ob mice reduces plasma [glucose] and [insulin]. We found that a leptin dose of 12.5 ng/hour significantly lowers blood glucose and that 25 ng/hour of leptin normalizes plasma glucose and insulin without significantly reducing body weight, thus establishing that leptin exerts its most potent effects on glucose metabolism. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3653

Platform:

GPL6885

8 Samples

Download data: TXT

(Submitter supplied) Background and aim: The Insulin-like growth factor (IGF) axis is increasingly suggested to be involved in fatty liver disease and progression. We identified IGFBP2 as transcriptional regulatory effect network in liver steatosis and conducted a translational approach of its role in liver pathology from mouse to human, and whether it is influenced by conventional clinical intervention that mitigate hepatic steatosis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

4 Samples

Download data: CEL, CHP