GEO DataSets

Analysis of aorta from hypercholesterolemic, apolipoprotein E (APOE)-null animals treated with captopril, an angiotensin-converting enzyme (ACE) inhibitor. Captopril attenuates atherosclerosis. Results provide insight into the molecular basis of the antiatherosclerotic effect of captopril.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 disease state, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE19286

6 Samples

Download data: CEL, CHP

(Submitter supplied) Microarray gene expression profiling of aorta genes of APOE-deficient mice receiving atherosclerosis treatment with the ACE inhibitor captopril. Hypercholesterolemic APOE-deficient mice were used as a standard model of atherosclerosis to study gene expression changes during atherosclerosis treatment with the ACE inhibitor captopril. Microarray analysis was performed of whole aortas isolated from captopril-treated APOE-deficient mice relative to untreated APOE-deficient mice with overt atherosclerosis, and nontransgenic control mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3683

Platform:

GPL1261

6 Samples

Download data: CEL, CHP

(Submitter supplied) Affymetrix Microarrays were used to analyse gene expression in aortas and circulating CD115+ cells of ApoE- and ApoE/Lymphotoxin beta receptor (LTbR)-double-deficent mice fed a Western diet from 8 to 12 weeks of age in order to identify regulated genes and pathways leading to reduced atherosclerosis in ApoE-/-/LTbR-/- mice compared to ApoE-/- littermate controls.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

14 Samples

Download data: CEL

(Submitter supplied) Hypercholesterolemic APOE-deficient mice are a widely used experimental model of atherosclerosis and increased generation of reactive oxygen species (ROS) is a prominent feature of atherosclerosis development. To study the impact of ROS on atherogenesis, we treated APOE-deficient mice for 7 months with the antioxidant vitamin E (2000 IU/kg diet) and performed whole genome microarray gene expression profiling of aortic genes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

6 Samples

Download data: CEL, CHP

(Submitter supplied) Extracellular senile plaques of amyloid beta (Abeta) are a pathological hallmark in brain of patients with Alzheimer`s Disease (AD). Abeta is generated by the amyloidogenic processing of the amyloid precursor protein (APP). Concomitant to Abeta load, AD brain is characterized by an increase in protein level and activity of the angiotensin-converting enzyme (ACE). ACE inhibitors are a widely used class of drugs with established benefits for patients with cardiovascular disease. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

6 Samples

Download data: CEL, CHP

(Submitter supplied) We performed high-throughput RNA sequencing to characterize possible differences in the transcriptome of bone marrow-derived macrophages from wilde type mice and EndoV knockout mice to further examine how ENDOV affect the CCL2 signaling. we stimulated both type of BMDMs with recombinant CCL2 and analyzed the transcriptome using mRNA sequencing analysis

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

6 Samples

Download data: H5, TSV