Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 20

1.
Full record GDS3795

Myelodysplastic syndrome: CD34+ hematopoietic stem cells

Analysis of bone marrow CD34+ hematopoietic stem cells of myelodysplastic syndrome (MDS) patients. MDS is a group of clonal hematopoietic stem cell malignancies characterized by ineffective hematopoiesis. Results provide insight into the molecular pathogenesis of MDS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state, 5 specimen sets
Platform:
GPL570
Series:
GSE19429
200 Samples
Download data: CEL
DataSet
Accession:
GDS3795
ID:
3795
2.

Expression data from bone marrow CD34+ cells of MDS patients and healthy controls

(Submitter supplied) In order to gain insight into the molecular pathogenesis of the myelodysplastic syndromes (MDS), we performed global gene expression profiling and pathway analysis on the hematopoietic stem cells (HSC) of 183 MDS patients as compared with the HSC of 17 healthy controls. The most significantly deregulated pathways in MDS include interferon signaling, thrombopoietin signaling and the Wnt pathway. Among the most significantly deregulated gene pathways in early MDS are immunodeficiency, apoptosis and chemokine signaling, whereas advanced MDS is characterized by deregulation of DNA damage response and checkpoint pathways. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3795
Platform:
GPL570
200 Samples
Download data: CEL
Series
Accession:
GSE19429
ID:
200019429
3.

Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Methylation profiling by genome tiling array
Platforms:
GPL16100 GPL2040
45 Samples
Download data: CEL, GPR
Series
Accession:
GSE41216
ID:
200041216
4.

Methylation profiling of Low-Risk Myelodysplastic Syndromes (MDSs)

(Submitter supplied) Genome-wide expression and methylation profiling identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes (MDSs). Gene expression profiling signatures may be used to classify the subtypes of Myelodysplastic syndrome (MDS) patients. However, there are few reports on the global methylation status in MDS. The integration of genome-wide epigenetic regulatory marks with gene expression levels would provide additional information regarding the biological differences between MDS and healthy controls. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL2040
20 Samples
Download data: GPR
Series
Accession:
GSE41215
ID:
200041215
5.

Expression profiling of Low-Risk Myelodysplastic Syndromes (MDSs)

(Submitter supplied) Genome-wide expression and methylation profiling identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes (MDSs). Gene expression profiling signatures may be used to classify the subtypes of Myelodysplastic syndrome (MDS) patients. However, there are few reports on the global methylation status in MDS. The integration of genome-wide epigenetic regulatory marks with gene expression levels would provide additional information regarding the biological differences between MDS and healthy controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16100
25 Samples
Download data: CEL
Series
Accession:
GSE41130
ID:
200041130
6.

Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukaemia (AML)

(Submitter supplied) A 10K cDNA microarray was used to compare neutrophil RNA from 21 MDS patient and 2 AML patients to pooled neutrophil RNA from 7 healthy controls. Keywords: repeat sample
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL334
45 Samples
Download data
Series
Accession:
GSE971
ID:
200000971
7.

Differential Gene Expression Profiles in CD34+ Myelodysplastic Syndrome Marrow cells to Disease Subtype and Progression

(Submitter supplied) Microarray analysis with 40,000 cDNA gene chip arrays determined differential gene expression profiles (GEPs) in CD34+ marrow cells from myelodysplastic syndrome (MDS) patients compared to normal individuals. Using focused bioinformatics analyses, we found 1175 genes significantly differentially expressed by MDS vs Normal, requiring a minimum of 39 genes to separately classify these patients. Major GEP differences were demonstrated between Normal and MDS patients and between several MDS subgroups: (1) those whose disease remained stable (sMDS) and those who subsequently transformed (tMDS) to acute myeloid leukemia (AML); (2) between del(5q) and other MDS patients. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL9335
41 Samples
Download data: TXT
Series
Accession:
GSE18366
ID:
200018366
8.

Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network

(Submitter supplied) Chromosome 5q deletions (del(5q)) are common in high-risk (HR) Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML); however, the gene regulatory networks that sustain these aggressive diseases are unknown. Reduced miR-146a expression in del(5q) HR-MDS/AML and miR-146a-/- hematopoietic stem/progenitor cells (HSPC) results in TRAF6/NF-κΒ activation. Increased survival and proliferation of HSPC from miR-146alow HR-MDS/AML is sustained by a neighboring haploid gene, SQSTM1 (p62), expressed from the intact 5q allele. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
9 Samples
Download data: CEL
Series
Accession:
GSE60649
ID:
200060649
9.

Gene expression profiling of myelodysplastic CD34+ hematopoietic stem cells treated in vitro with decitabine

(Submitter supplied) Epigenetic mechanisms contribute to deregulated gene expression of hematopoietic progenitors in Myelodysplastic Syndromes (MDS). Hypomethylating agents are able to improve peripheral cytopenias in MDS patients. To identify critical gene expression changes induced by hypomethylating agents, we analyzed gene expression profiling (GEP) of myelodysplastic and normal CD34+ hematopoietic stem cells treated in vitro with or without decitabine. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
30 Samples
Download data: CEL
Series
Accession:
GSE19610
ID:
200019610
10.

Precise Delination of 5q-Breakpoints and Detection of Hidden Aberrations in patients with MDS using Array CGH

(Submitter supplied) Isolated deletions of the long arm of chromosome 5 (del(5q)) are observed in 10% of myelodysplastic syndromes (MDS) and are associated with a more favorable prognosis, although the clinical course varies considerably. If one or more additional chromosomal aberration/s are present this correlates with a significant shorter overall survival. To assess the frequency of hidden abnormalities in cases with an isolated cytogenetic del(5q), we have performed a genome wide high resolution 44K 60mer oligonucleotide array CGH study using DNA from bone marrow cells of 12 MDS and one AML patient. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platforms:
GPL2873 GPL2879
13 Samples
Download data: TXT
Series
Accession:
GSE8804
ID:
200008804
11.

RNA sequencing of bone marrow CD34+ cells from myelodysplastic syndrome patients with and without SF3B1 mutation and from healthy controls

(Submitter supplied) The splicing factor SF3B1 is the most commonly mutated gene in the myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ring sideroblasts (RARS). MDS is a disorder of the hematopoietic stem cell and we thus studied the transcriptome of CD34+ cells from MDS patients with SF3B1 mutations using RNA-sequencing. Genes significantly differentially expressed at the transcript and/or exon level in SF3B1 mutant compared to wildtype cases include genes involved in MDS pathogenesis (ASXL1, CBL), iron homeostasis and mitochondrial metabolism (ALAS2, ABCB7, SLC25A37) and RNA splicing/processing (PRPF8, HNRNPD). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
17 Samples
Download data: TXT
Series
Accession:
GSE63569
ID:
200063569
12.

The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS

(Submitter supplied) Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on human chromosome 5q, associated with myelodysplastic syndrome (MDS) suggesting that haploinsufficiency of APC contributes to the MDS phenotype. Analysis of the hematopoietic system of mice with the Apcmin allele that results in a premature stop codon and loss of function, showed no abnormality in steady state hematopoiesis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE20352
ID:
200020352
13.

Gene expression profiling of AML

(Submitter supplied) AML/MDS patients carrying 11q amplifications involving the mixed lineage leukemia gene (MLL) locus are characterized by a later onset, a complex aberrant karyotype (CAK) frequently including deletions within 5q, 17p and 7q, as well as fast progression of the disease with extremely poor prognosis. We and other have shown that the MLL gene is over expressed in amplified cases, however, in most of the cases the amplified region is not restricted to the MLL locus. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
15 Samples
Download data: CEL
Series
Accession:
GSE10258
ID:
200010258
14.

Analysis of AML/MDS patients with 11q/MLL amplification

(Submitter supplied) AML/MDS patients carrying 11q amplifications involving the mixed lineage leukemia gene (MLL) locus are characterized by a complex aberrant karyotype (CAK) frequently including deletions within 5q, 17p and 7q, a later onset and fast progression of the disease with extremely poor prognosis. We and others have shown that the MLL gene is overexpressed in amplified cases; however, in most of the cases the amplified region is not restricted to the MLL locus. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL5000
12 Samples
Download data: GPR
Series
Accession:
GSE9928
ID:
200009928
15.

Understanding Early Stage Myelodysplastic Syndrome Pathobiology

(Submitter supplied) Delineating key HSC regulators is of significant interest for informing the treatment of hematologic malignancy. While HSC activity is enhanced by overexpression of SKI, the transforming growth factor-beta (TGFβ) signaling antagonist corepressor, its requirement in HSC is unknown. Here we reveal a profound defect in Ski-/- HSC fitness but not specification. Transcriptionally, Ski-/- HSC exhibited striking upregulation of TGFb superfamily signaling and splicing alterations. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
94 Samples
Download data: TXT
Series
Accession:
GSE115903
ID:
200115903
16.

NHD13 vs wild type LK cells

(Submitter supplied) Investigation of differences in gene expression between NHD13 mice with myelodysplastic syndrome and wild type littermates.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data: TXT
Series
Accession:
GSE39692
ID:
200039692
17.

Affymetrix SNP array data for 5q- myelodysplastic syndromes

(Submitter supplied) Myelodysplastic syndromes (MDS) are uncommon entities, heterogeneous clinically and cytogenetically. Recently, a new drug, Lenalidomide, has demonstrated to be very effective in patients with MDS and 5q- reaching 70% of hematological responses whereas patients with MDS without 5q- has only 20-30% of hematological responses. The aim of the present study is to determine genetic alteration in this subset of patients, and describe candidate genes related with response or resistance to Lenalidomide.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platform:
GPL6801
4 Samples
Download data: CEL, CNCHP
Series
Accession:
GSE59244
ID:
200059244
18.

Induced pluripotent stem cell modeling of bone marrow failure and MDS identifies therapeutic targets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
12 Samples
Download data
Series
Accession:
GSE118378
ID:
200118378
19.

The effect of spontaneous acquisition of an extra chromosome 7 for engineered del(7q) on induced pluripotent stem cells (iPSCs) derived from patients with Shwachman Diamond Syndrome (SDS).

(Submitter supplied) Monosomy 7 or deletion of 7q (del(7q)) frequently arise in inherited and acquired bone marrow failure, and are associated with progression to high grade Myelodysplastic Syndrome (MDS) and acute leukemia. Current non-transplant approaches to treat marrow failure may be complicated by potential stimulation of clonal outgrowth. To study the biological consequences of del(7q) within the context of a failing marrow, we utilized induced pluripotent stem cells (iPSCs) derived from patients with Shwachman Diamond Syndrome (SDS) and genomically engineered a deletion of (7q). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TXT
Series
Accession:
GSE118377
ID:
200118377
20.

The effect of engineered del(7q) on induced pluripotent stem cells (iPSCs) derived from patients with Shwachman Diamond Syndrome (SDS).

(Submitter supplied) Monosomy 7 or deletion of 7q (del(7q)) frequently arise in inherited and acquired bone marrow failure, and are associated with progression to high grade Myelodysplastic Syndrome (MDS) and acute leukemia. Current non-transplant approaches to treat marrow failure may be complicated by potential stimulation of clonal outgrowth. To study the biological consequences of del(7q) within the context of a failing marrow, we utilized induced pluripotent stem cells (iPSCs) derived from patients with Shwachman Diamond Syndrome (SDS) and genomically engineered a deletion of (7q). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TXT
Series
Accession:
GSE118372
ID:
200118372
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=3|blobid=MCID_6170f694326a155ba684b0de|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center