GEO DataSets

Analysis of HaCaT keratinocytes treated with alkylphospholipids (APLs) Ino-C2-PAF, Glc-PAF, and edelfosine. APLs interfere with a variety of key enzymes implicated in cell growth, motility, invasion, and apoptosis. Results provide insight into mechanism of action of APLs.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 agent sets

Platform:

GPL6480

Series:

GSE20722

12 Samples

Download data: TXT

(Submitter supplied) New alkyl-phospholipids (APLs) that are structurally derived from the platelet-activating factor are promising candidates for anticancer treatment. After the incorporation into cell membranes, APLs are able to interfere with a wide variety of key enzymes implicated in cell growth, motility, invasion and apoptosis. Besides the prototype edelfosine, we presented a novel group of APLs, glycosidated phospholipids that efficiently inhibit cell proliferation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3796

Platform:

GPL6480

12 Samples

Download data: TXT

(Submitter supplied) The cytotoxic drug edelfosine is a synthetic analog of 2-lysophosphatidylcholine. Edelfosine is incorporated by highly proliferating cells, e.g. activated immune cells. It is unknown if the described mechanisms for edelfosine action attained by in vitro approaches exclusively contribute to the observed EAE-amelioration or if edelfosine may exert additional, probably more general and possibly immunoablative effects within the setting of autoimmunity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS5304 GDS5544

Platform:

GPL6244

20 Samples

Download data: CEL

Analysis of stimulated CD4+ T cells (derived from buffy coat PBMCs) treated with edelfosine at 3.3µg/ml. Edelfosine is a cytotoxic drug taken up by highly proliferating cells such as activated immune cells. Results provide insight into the molecular basis of edelfosine action in immune T cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 protocol sets

Platform:

GPL6244

Series:

GSE44392

12 Samples

Download data: CEL

Analysis of unstimulated CD4+ T cells (derived from buffy coat PBMCs) treated with edelfosine at 3.3 or 10 µg/ml. Edelfosine is a cytotoxic drug taken up by highly proliferating cells such as activated immune cells. Results provide insight into molecular basis of edelfosine action in immune Tcells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 3 dose sets

Platform:

GPL6244

Series:

GSE44392

12 Samples

Download data: CEL