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Links from GEO DataSets

Items: 20

1.
Full record GDS3841

Lean and overweight-obese polycystic ovary syndrome patients: cultured cumulus cells

Analysis of cumulus cells from lean and overweight-obese polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization (IVF). PCOS is a heterogeneous endocrinopathy in women of reproductive age, mostly associated with ovulation failure. Results provide insight into PCOS pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 2 other sets
Platform:
GPL570
Series:
GSE10946
23 Samples
Download data: CEL
DataSet
Accession:
GDS3841
ID:
3841
2.

Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients

(Submitter supplied) Objective: The etiology of PCOS is mostly unknown. Existing data support both genetic and environmental factors in its pathogenesis. Design: Prospective case - control study. Setting: University Hospital. Patients: 25 patients undergoing IVF-ICSI treatment. Intervention: Genome-wide oligonucleotide microarray technology was used to study differential gene-expression patterns of cultured human cumulus cells from IVF patients divided into 4 groups according to disease state (PCOS vs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3841
Platform:
GPL570
23 Samples
Download data: CEL
Series
Accession:
GSE10946
ID:
200010946
3.

Expression data from human cumulus cells isolated from oocytes at MI and MII stages in polycystic ovary syndrome (PCOS) patients

(Submitter supplied) Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that is characterized by increased circulating androgen levels, anovulatory infertility, and frequently, insulin resistance and hyperinsulinemia.The abnormity of oocyte nuclear maturity is the main reason for anovulatory infertility and pregnancy loss in PCOS patients.The bidirectional exchanges between oocyte and contiguous CCs are important for oocyte competence acquisition, early embryonic development and CC expansion.Gene expression profiles of CCs has been suggested to predict embryo development and pregnancy outcome. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE40400
ID:
200040400
4.

Reduced expression of mitochondrial oxidative metabolism genes in skeletal muscle of women with PCOS

(Submitter supplied) Recently, abnormalities in mitochondrial oxidative phosphorylation (OXPHOS) have been implicated in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin resistance in the polycystic ovary syndrome (PCOS). Using the HG-U133 Plus 2.0 expression array from Affymetrix, we analyzed gene expression in skeletal muscle from obese women with PCOS (n=16) and age- and body mass index-matched control women (n=13) metabolically characterized by euglycemic-hyperinsulinemic clamp and indirect calorimetry. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3104
Platform:
GPL570
29 Samples
Download data: CEL
Series
Accession:
GSE6798
ID:
200006798
5.
Full record GDS3104

Insulin-resistant polycystic ovary syndrome: muscle

Analysis of vastus lateralis muscles from women with insulin-resistant polycystic ovary syndrome (PCOS). Insulin resistance in skeletal muscles is a risk factor for the development of type 2 diabetes in women with PCOS. Results provide insight into the pathogenesis of insulin resistance in PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE6798
29 Samples
Download data: CEL
DataSet
Accession:
GDS3104
ID:
3104
6.

miRNAs expression profile of the cumulus cell samples with PCOS and non-PCOS

(Submitter supplied) To reveal microRNAs expression differences in cumulus cells between polycystic ovary syndrome (PCOS) and non-PCOS women. miRNAs expression profile of the cumulus cell samples with PCOS and non-PCOS were determined by Affymetrix miRNA 2.0.
Organism:
Homo sapiens; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL14613
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE68285
ID:
200068285
7.

LncRNAs expression signatures of cumulus cells isolated from PCOS patients revealed by microarray

(Submitter supplied) Our study is the first one to determine genome-wide lncRNAs expression patterns in cumulus cells of PCOS patients by microarray. The results displayed that clusters of lncRNAs (n=623) were aberrantly expressed in PCOS patients compared with non-PCOS patients. Many differentially expressed lncRNAs were transcribed from regions on chromosome 2 and classified into enhancer-like lncRNA subgroup. XLOC_011402 (PWRN2) was found for the first time that it was not only expressed in testis but also in cumulus cells. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL19748
10 Samples
Download data: TXT
Series
Accession:
GSE65746
ID:
200065746
8.

Altered microRNA profiles in cumulus cells isolated from PCOS patients

(Submitter supplied) To identify the altered miRNA expression profiles of PCOS patients, the differentially expressed miRNAs were identified from cumulus cells of PCOS patients by comparing to that of normal women.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL16543
10 Samples
Download data: TXT
Series
Accession:
GSE72274
ID:
200072274
9.

Theca cell gene expression

(Submitter supplied) Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects 5-10% of reproductive aged women. The hallmark characteristic of PCOS is increased ovarian androgen synthesis. Previous studies by our laboratory demonstrated that increased androgen synthesis is a stable biochemical phenotype of PCOS theca cells which are the primary source of ovarian androgen production. The increase in theca cell steroidogenesis was due to an increase in expression of several steroidogenic enzymes including CYP17 and CYP11A but not StAR. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS1050 GDS1051
Platforms:
GPL96 GPL97
26 Samples
Download data: CEL, EXP
Series
Accession:
GSE1615
ID:
200001615
10.
Full record GDS1051

Valproic acid effect on theca cells (HG-U133B)

Analysis of normal theca cells treated with 500 uM valproic acid (VPA), an anti-epilipetic that induces polycystic ovary syndrome (PCOS)-like symptoms. Theca cells from PCOS patients also examined. Results provide insight into the underlying mechanisms contributing to VPA-induced PCOS-like symptoms.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 disease state sets
Platform:
GPL97
Series:
GSE1615
13 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS1051
ID:
1051
11.
Full record GDS1050

Valproic acid effect on theca cells (HG-U133A)

Analysis of normal theca cells treated with 500 uM valproic acid (VPA), an anti-epilipetic that induces polycystic ovary syndrome (PCOS)-like symptoms. Theca cells from PCOS patients also examined. Results provide insight into the underlying mechanisms contributing to VPA-induced PCOS-like symptoms.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 disease state sets
Platform:
GPL96
Series:
GSE1615
13 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS1050
ID:
1050
12.

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types from Women with Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

(Submitter supplied) Context: Endometrium in polycystic ovary syndrome (PCOS) presents altered gene expression indicating progesterone resistance and predisposing to reduced endometrial receptivity and endometrial cancer. Objective: We hypothesized that an altered endocrine/metabolic environment in PCOS may result in an endometrial “disease phenotype” affecting the gene expression of different endometrial cell populations, including stem cells and their differentiated progeny. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4987
Platform:
GPL6244
29 Samples
Download data: CEL
Series
Accession:
GSE48301
ID:
200048301
13.
Full record GDS4987

Polycystic ovary syndrome: proliferative phase endometrial cell types

Analysis of FACS-sorted endometrial cell types from proliferative phase endometrial biopsies collected from overweight/obese women with PCOS. Results provide insight into the molecular mechanisms underlying an endometrial disease phenotype in women with PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 cell type, 2 disease state sets
Platform:
GPL6244
Series:
GSE48301
29 Samples
Download data: CEL
14.

Expression data from cumulus cells that surround oocytes resulting in early or late cleaving embryos

(Submitter supplied) Besides the established selection criteria based on embryo morphology and blastomere number, new parameters for embryo viability are needed to improve the clinical outcome of in vitro fertilization (IVF) and more particular of elective single embryo transfer (eSET). The aim of the study was to analyse genome-wide whether the embryo viability was reflected by the expression of genes in the oocyte surrounding cumulus cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
16 Samples
Download data: CEL
Series
Accession:
GSE9526
ID:
200009526
15.

Folic acid supplementation normalizes the endothelial progenitor cell transcriptome of patients with type 1 diabetes

(Submitter supplied) Background: Endothelial progenitor cells play an important role in vascular wall repair. Patients with type 1 diabetes have reduced levels of endothelial progenitor cells of which their functional capacity is impaired. Reduced nitric oxide bioavailability and increased oxidative stress play a role in endothelial progenitor cell dysfunction in these patients. Folic acid, a B-vitamin with anti-oxidant properties, may be able to improve endothelial progenitor cell function. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3656
Platform:
GPL2700
32 Samples
Download data: TXT
Series
Accession:
GSE17635
ID:
200017635
16.
Full record GDS3656

Folic acid effect on endothelial progenitor cells of type 1 diabetes patients

Analysis of endothelial progenitor cells (EPCs) from patients with type 1 diabetes (T1D) before and 4 weeks of dietary folic acid (FA) supplementation. EPCs are involved in vascular wall repair. T1D results in reduced circulating EPCs. Results provide insight into the effect of FA on EPC function.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 disease state, 12 individual sets
Platform:
GPL2700
Series:
GSE17635
32 Samples
Download data
17.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3643
Platform:
GPL1355
24 Samples
Download data: CEL
Series
Accession:
GSE10748
ID:
200010748
18.
Full record GDS3643

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 6 dose sets
Platform:
GPL1355
Series:
GSE10748
24 Samples
Download data: CEL
DataSet
Accession:
GDS3643
ID:
3643
19.

Subcutaneous adipose tissue from lean and obese subjects

(Submitter supplied) Obtaining adipose tissue samples are paramount to the understanding of human obesity. We have examined the impact of needle-aspirated and surgical biopsy techniques on the study of subcutaneous adipose tissue (scAT) gene expression in both obese and lean subjects. Biopsy sampling methods have a significant impact on data interpretation and revealed that gene expression profiles derived from surgical tissue biopsies better capture the significant changes in molecular pathways associated with obesity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL7034 GPL7038
36 Samples
Download data: GPR
Series
Accession:
GSE12050
ID:
200012050
20.

Transcriptome Analysis of Human Injured Meniscus Reveals a Distinct Phenotype of Meniscus Degeneration with Aging

(Submitter supplied) In this study, we have tested the variation in gene expression signatures in human injured meniscus with age and degree of chondrosis in the knee. We found several genes that were differentially regulated with each of these factors and they represent important biological pathways in osteoarthritis research.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE45233
ID:
200045233
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