GEO DataSets

Analysis of PBMCs from chronically lonely, older adults. Lack of close social ties is a well-established risk factor for diseases involving the immune system and inflammation. Results provide insight into the molecular mechanisms underlying those effects.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 individual sets

Platform:

GPL6883

Series:

GSE25837

93 Samples

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(Submitter supplied) Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 93 older adults participating in the Chicago Health Aging and Social Relations Study (CHASRS). The primary research question is whether gene expression differs in participants who are chronically lonely. Keywords: Risk prediction

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3898

Platform:

GPL6883

93 Samples

Download data: TXT

(Submitter supplied) Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation. Keywords: Risk prediction

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3207

Platform:

GPL96

14 Samples

Download data: CEL

Analysis of leukocytes from individuals experiencing chronically high levels of subjective social isolation (loneliness). Social environment is known to influence human health. Results provide insight into transcriptional alterations in the immune system induced by chronic social isolation.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 individual sets

Platform:

GPL96

Series:

GSE7148

14 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 4 mo old rhesus macaques subject to maternal rearing, peer rearing, or surrogate peer rearing. The primary research question is whether gene expression differs as a function of early rearing conditions.

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

13 Samples

Download data: CEL

(Submitter supplied) Loneliness is associated with impaired mental and physical health. Studies of lonely individuals reported differential expression of inflammatory genes in peripheral leukocytes and diminished activation in brain reward regions such as nucleus accumbens, but could not address gene expression in the human brain. Here, we examined genome-wide RNA expression in postmortem nucleus accumbens from donors (N = 26) with known loneliness measures. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15314

26 Samples

Download data: TXT

(Submitter supplied) Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10904

100 Samples

Download data: TXT

(Submitter supplied) Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10904

92 Samples

Download data: TXT

(Submitter supplied) Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10399

93 Samples

Download data: TXT

(Submitter supplied) Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10399

62 Samples

Download data: TXT

(Submitter supplied) Differences in basal leukocyte gene expression profiles in macaques classified as showing low, moderate, or high behavioral indications of perceived social isolation (PSI)

Organism:

Homo sapiens; Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL10904

56 Samples

Download data: TXT

(Submitter supplied) Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10399

98 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

32 Samples

Download data: CEL

(Submitter supplied) Background: Biological interpretation of gene expression data may differ depending on underlying assumptions and statistical tests used by the chosen bioinformatic tool. We used Gene Set Enrichment Analysis (GSEA) and Ingenuity Pathway Analysis (IPA) to analyze previously generated gene expression profiles induced in human monocytes by N. meningitidis and IL-10 (“the model system”), and by meningococcal sepsis plasma before and after immunodepletion of IL-10 (“the patient plasma system”). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

12 Samples

Download data: CEL

(Submitter supplied) Background: Biological interpretation of gene expression data may differ depending on underlying assumptions and statistical tests used by the chosen bioinformatic tool. We used Gene Set Enrichment Analysis (GSEA) and Ingenuity Pathway Analysis (IPA) to analyze previously generated gene expression profiles induced in human monocytes by N. meningitidis and IL-10 (“the model system”), and by meningococcal sepsis plasma before and after immunodepletion of IL-10 (“the patient plasma system”). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

20 Samples

Download data: CEL

(Submitter supplied) The Human T-cell Leukemia Virus (HTLV)-type-I non-structural protein p30 plays an important role in virus transmission and gene regulation. p30 has been documented to inhibit the export of certain viral mRNA transcripts from the nucleus to the cytoplasm. This nuclear retainment of RNA molecules essentially results in gene silencing, where protein products are not produced. Considering this unique function of p30, we used microarray analysis to assess the ability of p30 to inhibit not only the regulation of transcription of cellular genes, but also the ability of p30 to regulate the export of cellular transcripts to the cytoplasm.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

4 Samples

Download data: CEL, CHP

(Submitter supplied) Monocyte-derived dendritic cells (DC) and macrophages (MΦ) generated in vitro from the same individual blood donors were exposed to five different pathogens, and gene expression profiles were assessed by microarray analysis. Responses to Mycobacterium tuberculosis and to phylogenetically distinct protozoan (Leishmania major, L. donovani, Toxoplasma gondii) and helminth (Brugia malayi) parasites were examined, each of which produces chronic infections in humans yet vary considerably in the nature of the immune responses they trigger. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

28 Samples

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(Submitter supplied) Blood genomic profiling has been applied to disorders of the blood and various organ systems including brain to elucidate disease mechanisms and identify surrogate disease markers. Since most studies have not examined specific cell types, we performed a preliminary genomic survey of major blood cell types from normal individuals using microarrays. CD4+ T cells, CD8+ T cells, CD19+ B cells, CD56+ natural killer cells, and CD14+ monocytes were negatively selected using the RosetteSep antibody cocktail, while polymorphonuclear leukocytes were separated with density gradient media. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

18 Samples

Download data: CEL

(Submitter supplied) SAGE was used to profile gene expression in leukemic myeloid progenitor cells of AML patients with t(8;21), t(15;17), t(9;11) and inv(16). Keywords: SAGE analysis of gene expression in leukemic myeloid progenitor cells isolated from bone marrow

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL4

22 Samples

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(Submitter supplied) Background: Expression level of many genes shows abundant natural variation in human populations. The variations in gene expression are believed to contribute to phenotypic differences. Emerging evidence has shown that microRNAs (miRNAs) are one of the key regulators of gene expression. However, past studies have focused on the miRNA target genes and use loss- or gain-of-function approach that may not reflect natural association between miRNA and mRNAs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL6102 GPL8178

180 Samples

Download data: TXT