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Links from GEO DataSets

Items: 20

1.
Full record GDS3912

Adrenocortical adenomas harboring β-catenin gene CTNNB1 mutations

Analysis of adrenocortical adenomas (AA) with β-catenin missense mutations and AAs with wild-type CTNNB1. Mutations of CTNNB1 are common in AA and adrenocortical carcinomas (ACC). Results provide insight into molecular mechanisms deregulated in adrenocortical tumors with CTNNB1 genetic alterations.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 genotype/variation, 3 other, 2 tissue sets
Platform:
GPL570
Series:
GSE28476
8 Samples
Download data: CEL
DataSet
Accession:
GDS3912
ID:
3912
2.

Characterization of differential gene expression in adrenocortical tumors harbouring β-catenin (CTNNB1) mutations.

(Submitter supplied) Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes of CTNNB1 have not yet been identified in adrenocortical tumors. Our objective was to identify genes de-regulated in adrenocortical tumors harbouring CTNNB1 genetic alterations.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3912
Platform:
GPL570
8 Samples
Download data: CEL
Series
Accession:
GSE28476
ID:
200028476
3.

Gene exrpression profiling of childhood adrenocortical tumors

(Submitter supplied) Pediatric adrenocortical tumors (ACT) are rare and often fatal malignancies; little is known regarding their etiology and biology. To provide additional insight into the nature of ACT, we determined the gene expression profiles of 24 pediatric tumors (five adenomas, 18 carcinomas, and one undetermined) and seven normal adrenal glands. Distinct patterns of gene expression, validated by quantitative real-time PCR and Western blot analysis, were identified that distinguish normal adrenal cortex from tumor. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
31 Samples
Download data: CEL
Series
Accession:
GSE75415
ID:
200075415
4.

Beta-catenin status effects in human adrenocortical carcinomas (33), adenomas (22), and normal adrenal cortex (10)

(Submitter supplied) We scored adrenocortical carcinomas and adenomas for abnormal beta-catenin staining, and sequenced the beta-catenin gene in some samples. We compared adrenocortincal carcinomas with and without abnormal beta-catenin staining and found many significant expression differences and significant results from enrichment testing. A similar comparison in the adenomas gave relatively few differences, and they did not correlate to differences found for the carcinomas. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
65 Samples
Download data: CEL, XLS
Series
Accession:
GSE33371
ID:
200033371
5.

Genome wide DNA Methylation analysis of benign and malignant adrenocortical tumors

(Submitter supplied) Genome wide DNA methylation profiling of normal adrenocortical tissue, adrenocortical adenomas and adrenocortical carcinomas. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles. Samples included 6 normal adrenocortical tissue samples, 27 adenomas and 15 carcinomas.
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL8490
48 Samples
Download data: TXT
Series
Accession:
GSE36353
ID:
200036353
6.

Analysis of adrenocortical tumors identify IGF2 and Ki-67 as useful in differentiating carcinomas from adenomas

(Submitter supplied) Purpose: The management of adrenocortical tumors (ACTs) is complex, compounded by the difficulty in discriminating benign from malignant tumors using conventional histology. The Weiss score is the current most widely used system for ACT diagnosis but it has limitations, particularly with ACTs with a score of 3. The am of this study was to identify molecular markers whose expression can discriminate adrenocortical carcinomas (ACCs) from adrenocortical adenomas (ACAs) by microarray gene expression profiling and to determine their clinical applicability by using immunohistochemistry (IHC). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
34 Samples
Download data: CEL, CHP
Series
Accession:
GSE12368
ID:
200012368
7.

SNP array profiling of childhood adrenocortical tumours reveals distinct pathways of tumourigenesis and highlights candidate driver genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platforms:
GPL6985 GPL6986 GPL8887
31 Samples
Download data
Series
Accession:
GSE35066
ID:
200035066
8.

SNP data from 12 childhood adrenocortical tumors from outside Brazil

(Submitter supplied) SNP array data from 12 childhood adrenocortical tumors (ACT) were used to identify recurrent chromosome rearrangements and candidate driver genes.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platforms:
GPL6986 GPL8887
12 Samples
Download data: TXT
Series
Accession:
GSE35064
ID:
200035064
9.

SNP data from 13 childhood adrenocortical tumours from Brazilian patients and 6 matched normal samples

(Submitter supplied) SNP array data from 13 Brazilian childhood adrenocortical tumors (ACTs) were analyzed to detect recurrent copy number changes and highlight potential candidate driver genes.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platforms:
GPL6986 GPL6985
19 Samples
Download data
Series
Accession:
GSE24804
ID:
200024804
10.

Deregulated miRNAs in adrenocortical tumors

(Submitter supplied) We performed miRNA expression profiling in a series of adrenocortical carcinomas, adrenocortical adenomas and normal adreno cortex using a microarray approach. Significant differentially expressed miRNAs among groups were identified using SAM analysis.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL13347
52 Samples
Download data: TXT
Series
Accession:
GSE22816
ID:
200022816
11.

Adrenocortical Carcinoma Gene Expression Profiling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL887 GPL570
63 Samples
Download data: CEL, TXT
Series
Accession:
GSE19776
ID:
200019776
12.

Adrenocortical Carcinoma Gene Expression Profiling [Agilent]

(Submitter supplied) Adrenocortical carcinoma (ACC) is an aggressive endocrine tumor with a poor 5 year survival rate of 10-20%. We used expression profiling to assess the transcriptional changes associated with ACC as compared to normal adrenal glands with the goal of identifying new targets for treatment. Fourteen ACC tumors were profiled on both Affymetrix U133 Plus 2 or Agilent 22K Human Genome arrays; an additional six tumors were profiled on one or the other array. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
15 Samples
Download data: TXT
Series
Accession:
GSE19775
ID:
200019775
13.

Adrenocortical Carcinoma Gene Expression Profiling [Affymetrix]

(Submitter supplied) Background: Adrenocortical carcinoma (ACC) is associated with poor survival rates. The objective of the study was to analyze ACC gene expression profiling data prognostic biomarkers and novel therapeutic targets. Methods: 44 ACC and 4 normal adrenal glands were profiled on Affymetrix U133 Plus 2 expression microarrays and pathway and transcriptional enrichment analysis performed. Protein levels were determined by western blot. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
48 Samples
Download data: CEL, TXT
Series
Accession:
GSE19750
ID:
200019750
14.

microRNA expression analysis of metastatic adrenocortical tumors

(Submitter supplied) Background: Adrenocortical carcinoma (ACC) is a rare, often-aggressive neoplasm of the adrenal cortex, with a 14.5-month median overall survival. We asked whether tumors from patients with advanced or metastatic ACC would offer clues as to putative genes that might have critical roles in disease progression or in more aggressive disease biology. Methods: We conducted comprehensive genomic and expression analyses, including microRNA profiling, of 33 ACCs and 6 normal adrenals. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL27982
39 Samples
Download data
Series
Accession:
GSE143385
ID:
200143385
15.

Gene expression analysis of metastatic adrenocortical tumors

(Submitter supplied) Background: Adrenocortical carcinoma (ACC) is a rare, often-aggressive neoplasm of the adrenal cortex, with a 14.5-month median overall survival. We asked whether tumors from patients with advanced or metastatic ACC would offer clues as to putative genes that might have critical roles in disease progression or in more aggressive disease biology. Methods: We conducted comprehensive genomic and expression analyses of 43 ACCs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16043
63 Samples
Download data: CEL, CHP
Series
Accession:
GSE143383
ID:
200143383
16.

Human Adrenocortical Tumors: normal cortex vs inactive adenoma vs cortisol secreting adenoma vs adrenocortical cancer

(Submitter supplied) Transcriptional profiling of human adrenocortical tumors. Gene expression profile of normal adrenal cortex, hormonally inactive adenoma, cortisol-secreting Cushing-adenoma and primary adrenocortical cancer tissues were compared. The goal of this study was to identify significant differences in the gene expression of these groups. Further aim was to reveal biologically relevant pathogenetic pathways altered at transcriptional and posttranscriptional level, as well.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
16 Samples
Download data: TXT
Series
Accession:
GSE14922
ID:
200014922
17.

SNP data from 76 adrenocortical carcinomas

(Submitter supplied) SNP array data from 76 adrenocortical carcinomas were used to detect recurrent copy number alterations.
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL17913
76 Samples
Download data
Series
Accession:
GSE52296
ID:
200052296
18.

Integrated genomic analyses of adrenocortical tumors (SNP array, DNA methylation, mRNA and miRNA expression).

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by high throughput sequencing; SNP genotyping by SNP array; Methylation profiling by genome tiling array; Genome binding/occupancy profiling by array
6 related Platforms
324 Samples
Download data: CEL
Series
Accession:
GSE49280
ID:
200049280
19.

Micro-RNA sequencing from 78 adrenocortical carcinomas

(Submitter supplied) Micro-RNA sequencing of adrenocortical tumors and normal adrenal samples.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL11154
78 Samples
Download data: TXT
Series
Accession:
GSE49279
ID:
200049279
20.

Expression profiling by array of 44 adrenocortical carcinomas

(Submitter supplied) Gene expression profiles of adrenocortical carcinomas were analyzed using Affymetrix Human Gene 2.0 ST Array to identify homogeneous molecular subgroups
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
44 Samples
Download data: CEL
Series
Accession:
GSE49278
ID:
200049278
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