GEO DataSets

Analysis of skeletal muscle of C57BL/6J males fed a high fat diet (HFD) for 8 weeks to induce obesity and insulin resistance. Results provide insight into the molecular mechanisms underlying the development of diet-induced obesity and insulin resistance.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 growth protocol, 2 time sets

Platform:

GPL7546

Series:

GSE17576

30 Samples

Download data: CEL

(Submitter supplied) An 8-week high fat palm oil diet causes obesity and insulin resistance in C57BL/6J mice, but induces only small changes in the muscle transcriptome. Introduction: The metabolic syndrome (MS) is a cluster of metabolic abnormalities linked to an increased risk of type 2 diabetes and cardiovascular diseases. Two major characteristics of the MS are obesity and insulin resistance. In the present study we investigated the effect of obesity and insulin resistance on the mouse muscle transcriptome. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4015

Platform:

GPL7546

30 Samples

Download data: CEL

(Submitter supplied) There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play a causal role. In this experiment, we have studied all these aspects to validate the suggested protective effect of Ca supplementation, independent of other dietary changes, on the development of diet-induced obesity and insulin resistance. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3831

Platform:

GPL1261

6 Samples

Download data: CEL, EXP

Analysis of small intestine (proximal, middle, distal) mucosal cells of C57BL/6J males fed high-fat diets differing in Ca concentration. High-Ca (150mmol/kg) stimulates fecal fat and bile acid excretion. Results provide insight into role of dietary Ca on development of obesity or insulin resistance.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol, 3 tissue sets

Platform:

GPL1261

Series:

GSE18581

6 Samples

Download data: CEL, EXP

(Submitter supplied) High energy intake and, specifically, high dietary fat intake challenges the mammalian metabolism and correlates with many metabolic disorders, such as obesity and diabetes. Dietary restriction (DR) is, on the other hand, known to prevent the development of metabolic disorders. The current Western diets are highly enriched in fat and it is as yet unclear whether DR on a certain high-fat (HF) diet elicits similar beneficial effects on health. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3986

Platform:

GPL7202

36 Samples

Download data: TXT

Analysis of epididymal WAT from C57BL/6J adult males adapted to a high-fat diet for 3 wks, then fed a high-fat diet on an ad-libitum basis (HF-AL) or on a restricted basis (HF-DR) for 12 wks. Results provide insight into molecular mechanisms underlying improved metabolic health induced by HF-DR.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL7202

Series:

GSE27213

36 Samples

Download data: TXT

(Submitter supplied) This experiment was conducted to identify target genes of the peroxisome proliferator-activated receptor alpha (PPARa) in skeletal muscle of transgenic mice that overexpressed PPARa. The following abstract from the published manuscript describes the major findings of this work. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2289

Platform:

GPL339

4 Samples

Download data

Analysis of skeletal muscles of transgenics (trs) overexpressing PPARalpha. Trs overexpressing PPARalpha develop glucose intolerance despite protection from diet-induced obesity. Results provide insight into the role of PPARalpha in the development of insulin-resistant diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE5777

4 Samples

Download data

(Submitter supplied) The prevalence of the metabolic syndrome (MS) is rapidly increasing all over the world. Consequently, there is an urgent need for more effective intervention strategies. Both animal and human studies indicate that lipid oversupply to skeletal muscle can result in insulin resistance which is one of the charecteristices of the MS. C57BL/6J mice were fed a low fat (10 kcal%) palm oil diet or a high fat (45 kcal%; HF) palm oil diet for 3 or 28 days. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3078

Platform:

GPL5766

24 Samples

Download data: CEL

Analysis of skeletal muscles of C57BL/6J animals fed a low or high fat diet for 3 or 28 days. Oversupply of lipid to skeletal muscle can result in insulin resistance, a characteristic of metabolic syndrome (MS). Results provide insight into the molecular events underlying the early onset of MS.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol, 2 time sets

Platform:

GPL5766

Series:

GSE8524

24 Samples

Download data: CEL

(Submitter supplied) Timecourse analysis of the effect high fat and low fat diets have on liver gene expression. C57 and AJ strains examined at 0, 1, 3, 4, 5 ,6, 7, 8, 9, 10 and 11 weeks. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL359

435 Samples

Download data

(Submitter supplied) Excessive intake of dietary fat is known to be a contributing factor in the development of obesity. In this study, we determined the dose-dependent effects of dietary fat on the development of this metabolic condition with a focus on changes in gene expression in the small intestine. C57BL/6J mice were fed diets with either 10, 20, 30 or 45 energy% (E%) derived from fat for four weeks (n=10 mice/diet). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7440

120 Samples

Download data: CEL