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Links from GEO DataSets

Items: 14

1.
Full record GDS4074

Zinc finger transcription factor induced fulvestrant resistant MCF7-R73 breast cancer cell lines

Analysis of fulvestrant-sensitive MCF7-R73 cells retrovirally induced with various zinc finger transcription factors. Six unique ZF-TFs conferred stable fulvestrant-resistance. Results provide insight into molecular mechanisms underlying acquired fulvestrant-resistance in breast cancer cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 7 genotype/variation, 2 infection sets
Platform:
GPL570
Series:
GSE27444
14 Samples
Download data: CEL
2.

Expression data from zinc-finger-transcription-factor-induced Fulvestrant-Resistant MCF7 Cell Lines

(Submitter supplied) Multiple gene expression studies have demonstrated that breast cancer biological diversity is associated with distinct transcriptional programs. Transcription factors, because of their unique ability to coordinate the expression of multiple genes, are speculated to play a role in generating phenotypic plasticity associated with cancer progression including acquired drug resistance. Combinatorial libraries of artificial zinc-finger transcription factors (ZF-TFs) provide a robust means for inducing and understanding various functional components of the cancer phenotype. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4074
Platform:
GPL570
14 Samples
Download data: CEL
Series
Accession:
GSE27444
ID:
200027444
3.

The expression patterns of 17b-estradiol responsive genes in wt MCF7, OHT resistant MCF7 and ICI resistant MCF7

(Submitter supplied) Compare the expression pattern of 17b-estradiol responsive genes in parent, OHT-resistant and ICI-resistant breast cancer cells. Keywords: 17b-estradiol responsive genes, OHT resistance, Fulvestrand resistance
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
24 Samples
Download data
Series
Accession:
GSE5840
ID:
200005840
4.

Integrative Analyses of Gene Expression and DNA Methylation Profiles in a Breast Cancer Cell Line Model of Tamoxifen-Resistance Indicate a Crucial Role of Cells with Stem-like Properties

(Submitter supplied) Purpose: Development of resistance to tamoxifen is an important clinical issue in the treatment of patients with breast cancer. Tamoxifen resistance may be the result of the acquisition of epigenetic regulation such as DNA methylation within breast cancer cells resulting in changed mRNA expression of genes being pivotal for estrogen dependent growth. Alternatively, tamoxifen resistance may be due to selection of preexisting resistant cells, which may exhibit cancer stem-like characteristics or a combination of the two mechanisms. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platform:
GPL11154
10 Samples
Download data: TXT
Series
Accession:
GSE40665
ID:
200040665
5.

Genome-wide maps of Tamoxifen resistance MCF7 cell line

(Submitter supplied) We report the ER alpha regulatory network of Tamoxifen resistance MCF7 cell line using the Chromatin immunoprecipitated high-throughput sequencing technology (ChIP-seq). By Integrating the gene expression data (previously reported) with the ChIP-seq data, we generated ER alpha regulatory network and pathways. For ER alpha regulatory network, hub TFs with enriched motifs were identified from ER alpha peak together with PolII peaks. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9052
4 Samples
Download data: BED
Series
Accession:
GSE26083
ID:
200026083
6.

Gene expression patterns associated with p53 status in breast cancer

(Submitter supplied) Breast cancer subtypes identified in genomic studies have different underlying genetic defects. Mutations in the tumor suppressor p53 occur more frequently in estrogen receptor (ER) negative, basal-like and HER2-amplified tumors than in luminal, ER positive tumors. Thus, because p53 mutation status is tightly linked to other characteristics of prognostic importance, it is difficult to identify p53's independent prognostic effects. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL887 GPL885
48 Samples
Download data
Series
Accession:
GSE3178
ID:
200003178
7.

Estrogen- and Myc-regulated genes in MCF-7 breast cancer cells

(Submitter supplied) Estrogen-responsive genes were identified by transcript profiling of estrogen-treated MCF-7 breast cancer cells. The gene expression profile generated after estrogen treatment was compared with that following inducible expression of c-Myc or c-Zip (a deletion mutant of c-Myc that lacks the N-terminal transactivation domains) in clonal MCF-7 cell lines. Keywords: Single time point
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
15 Samples
Download data: CEL
Series
Accession:
GSE11791
ID:
200011791
8.

The C2H2-ZF transcription factor Zfp335 recognizes two consensus motifs using separate zinc finger arrays

(Submitter supplied) The complexities of DNA recognition by transcription factors with multiple Cys2-His2 zinc fingers (C2H2-ZFs) remain poorly studied. We previously reported a mutation (R1092W) in the C2H2-ZF transcription factor Zfp335 which led to selective loss of binding at a subset of targets, although the basis for this was unclear. We show that Zfp335 binds DNA and drives transcription via recognition of two distinct consensus motifs by separate ZF clusters, and identify the specific motif interaction disrupted by R1092W. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: BW, NARROWPEAK
Series
Accession:
GSE83116
ID:
200083116
9.

Genome-wide profiling of Zfp335 binding sites in thymocytes

(Submitter supplied) The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein Zfp335. Mutant blt/blt mice exhibit a naïve T cell deficiency due to an intrinsic developmental defect that begins to manifest in the thymus and continues into the periphery, affecting T cells that have recently undergone thymic egress. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
6 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE58333
ID:
200058333
10.

Zinc finger protein Zfp335 is required for formation of the naïve T cell compartment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17777 GPL13112
18 Samples
Download data: BIGWIG, CEL, TXT
Series
Accession:
GSE58293
ID:
200058293
11.

Gene expression profiling of recent thymic emigrants (RTEs) from a mouse strain with an ENU-induced mutation in Zfp335

(Submitter supplied) The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein Zfp335. Mutant blt/blt mice exhibit a naïve T cell deficiency due to an intrinsic developmental defect that begins to manifest in the thymus and continues into the periphery, affecting T cells that have recently undergone thymic egress. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17777
6 Samples
Download data: CEL
Series
Accession:
GSE58289
ID:
200058289
12.

Gene expression profiling of mature CD4 SP thymocytes from a mouse strain with an ENU-induced mutation in Zfp335

(Submitter supplied) The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein Zfp335. Mutant blt/blt mice exhibit a naïve T cell deficiency due to an intrinsic developmental defect that begins to manifest in the thymus and continues into the periphery, affecting T cells that have recently undergone thymic egress. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17777
6 Samples
Download data: CEL
Series
Accession:
GSE58288
ID:
200058288
13.

The Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance (pooled shRNA screens)

(Submitter supplied) Large-scale genomic studies have identified multiple somatic aberrations in breast cancer, including copy number alterations, and point mutations. Still, identifying causal variants and emergent vulnerabilities that arise as a consequence of genetic alterations remain major challenges. We performed whole genome shRNA "dropout screens" on 77 breast cancer cell lines. Using a hierarchical linear regression algorithm to score our screen results and integrate them with accompanying detailed genetic and proteomic information, we identify vulnerabilities in breast cancer, including candidate "drivers," and reveal general functional genomic properties of cancer cells. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL21133
621 Samples
Download data: CEL
Series
Accession:
GSE74702
ID:
200074702
14.

The Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance (RNASeq)

(Submitter supplied) Large-scale genomic studies have identified multiple somatic aberrations in breast cancer, including copy number alterations, translocations, and point mutations. Still, identifying causal variants and emergent vulnerabilities that arise as a consequence of genetic alterations remain major challenges. We performed whole genome shRNA “dropout screens” on 77 breast cancer cell lines. Using a new hierarchical linear regression algorithm to score our screen results and integrate them with accompanying detailed genetic and proteomic information, we identify novel vulnerabilities in breast cancer, including new candidate “drivers,” and reveal general functional genomic properties of cancer cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
82 Samples
Download data: TXT
Series
Accession:
GSE73526
ID:
200073526
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