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Links from GEO DataSets

Items: 14

1.
Full record GDS4120

Androgen deprivation effect on prostate xenograft tumor LuCaP35

NOD/SCID mice with established LuCaP35 xenografts were castrated, and tumors were isolated 4 weeks later. Androgen deprivation regresses androgen-dependent disease, but relapse often occurs in an androgen-independent manner. Results provide insight into the molecular basis of castration resistance.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL570
Series:
GSE33316
10 Samples
Download data: CEL
DataSet
Accession:
GDS4120
ID:
4120
2.

Gene expression profiling of mouse prostate stem cells

(Submitter supplied) The mouse prostate tissue exhibits strong power of regeneration, indicating the exisistence of prostate stem cells. Previously we showed that a single mouse prostate cells defined by Lin-CD44+CD133+Sca-1+CD117+ phenotype can generate a prostate after transplantation in vivo. In this study, we compared gene expression profiles of mouse prostate stem cells ( Lin-CD44+CD133+Sca-1+CD117+) and prostate non-stem cells (Lin-CD44-CD133-Sca-1-CD117-).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
9 Samples
Download data: TXT
Series
Accession:
GSE33317
ID:
200033317
3.

The effect of androgen deprivation on human prostate xenograft tumor LuCaP35

(Submitter supplied) Androgen deprivation is a standard of care front-line therapy for human prostate cancer, however, majority of patients will eventally develop resistance to androgen deprivation. In this study, using a human prostate cancer xenograft model -LuCaP35, we examiend the gene expression changes after castration.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4120
Platform:
GPL570
10 Samples
Download data: CEL, TXT
Series
Accession:
GSE33316
ID:
200033316
4.

Human prostate cancer xenografts on intact mice or after castration.

(Submitter supplied) cDNA expression arrays on a panel of human prostate cancer xenografts. The xenografts can divided into three groups: 1) androgen-dependent, 2) androgen-independent with functional expression of the androgen receptor, 3) androgen-independent lacking functional expression of the androgen receptor. Four microarrays were performed per xenograft using tissue samples collected in separate experiments. Two samples were taken from intact male mice, whereas the other two samples were taken 1 to 2 weeks after castration. more...
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2384
Platform:
GPL3349
52 Samples
Download data
Series
Accession:
GSE4084
ID:
200004084
5.

Prostate cancer cell line LNCaP treated for 2, 4, 6, 8 h with the synthetic androgen R1881 (1nM)

(Submitter supplied) Time series of the prostate cancer cell line LNCaP, treated for 2, 4, 6 and 8 hours with the synthetic androgen R1881. As control, the cells were cultured for 2, 4, 6 and 8 hours in the presence of the same concentration of solvent (ethanol). With this short treatment time, we aimed to identify mainly direct targets of the androgen receptor. LNCaP has a very low growth rate in steroid stripped medium and resumes growth on addition of androgens. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2034
Platform:
GPL3349
8 Samples
Download data
Series
Accession:
GSE4027
ID:
200004027
6.
Full record GDS2384

Xenograft model of prostate carcinoma progression

Analysis of prostate cancer (PC) xenografts collected from male mice up to 14 days after castration. The androgen receptor (AR) plays a pivotal role in the growth and survival of prostate carcinoma. Results provide insight into the role of selective adaptations of the AR pathway in PC progression.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array, log2 ratio, 4 disease state, 3 other, 10 protocol, 14 specimen sets
Platform:
GPL3349
Series:
GSE4084
52 Samples
Download data
DataSet
Accession:
GDS2384
ID:
2384
7.
Full record GDS2034

Prostate cancer cell line LNCaP response to synthetic androgen R1881: time course

Expression profiling of prostate cancer cell line LNCaP treated for up to 8 hours with the synthetic androgen R1881. LNCaP cells grow slowly in medium devoid of steroids but resume growth upon the addition of androgens. The study aims to identify direct targets of the androgen receptor.
Organism:
Homo sapiens
Type:
Expression profiling by array, log2 ratio, 4 time sets
Platform:
GPL3349
Series:
GSE4027
8 Samples
Download data
DataSet
Accession:
GDS2034
ID:
2034
8.

TMPRSS2 Influences Prostate Cancer Metastasis

(Submitter supplied) TMPRSS2 is an androgen-regulated cell surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastasis. Through the generation of mouse models with a targeted deletion of Tmprss2, we demonstrate that the activity of this protease regulates cancer cell invasion and metastasis to distant organs. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4070
9 Samples
Download data: GPR
Series
Accession:
GSE58822
ID:
200058822
9.

The ETS transcription factor ESE3 controls prostate epithelial cell differentiation

(Submitter supplied) ETS transcription factors have recently emerged as important elements in the pathogenesis of prostate cancer (PCa). ETS gene rearrangements leading to over-expression of ETS factors, like ERG, ETV1 and ETV4, are found in about 50% of prostate tumors. While the oncogenic potential of translocated ETS has been demonstrated in several contexts, the impact of endogenously expressed ETS factors on prostate tumorigenesis has been largely overlooked. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
1 Sample
Download data: TXT
Series
Accession:
GSE23197
ID:
200023197
10.

Transcriptomic Effects of SSX2 on a Prostate Cancer Cell Line

(Submitter supplied) Prostate cancer is the most commonly diagnosed malignancy in the United States. While the majority of cases are cured with radiation or surgery, about 1/3 of patients will develop metastatic disease which there is no cure, and has a life expectancy of less than 5 years. Identification of antigens associated with this transition to metastatic disease is crucial for future therapies. One such antigen of interest is the SSX gene family, which are cancer/testis antigens that are associated with the epithelial to mesenchymal transition in other cancer types. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
9 Samples
Download data: CEL, CHP
Series
Accession:
GSE77811
ID:
200077811
11.

Motility and stem cell properties induced by the epithelial-mesenchymal transition require destabilization of lipid rafts

(Submitter supplied) The epithelial-mesenchymal transition provides cells with the characteristics needed to metastasize. We hypothesized that it does so through changes in the organization of the plasma membrane. We found that the EMT leads to destabilization of the membrane concomitant with transcriptional reprogramming. However, treatment with DHA stabilizes the membrane and reverts the transcriptional program toward an epithelial state.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
6 Samples
Download data: IDAT, TXT
Series
Accession:
GSE72226
ID:
200072226
12.

KLF4, a gene regulating prostate stem cell homeostasis, is a barrier to malignant progression and predictor of a good prognosis in prostate cancer

(Submitter supplied) We propose that genes that control adult stem cell homeostasis in slowly turning over organs, such as prostate, control cancer fate. One such gene, KLF4, highly expressed in murine prostate stem cells, regulates their homeostasis, blocks malignant transformation and controls the self-renewal of tumor initiating cells. KLF4 loss induces molecular features of aggressive cancer and converts PIN lesions to invasive sarcomatoid carcinomas; its re-expression in vivo reverses this process. more...
Organism:
Mus musculus
Type:
Expression profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
14 Samples
Download data: BW
13.

Androgen deprivation in PTEN/LXR -/- mice

(Submitter supplied) The project is based on the transcriptomic analysis from 8 groups of animal samples : Wild Type Sham Wild Type Castrated LXR-/- Sham LXR-/- Castrated PTEN-/- Sham PTEN-/- Castrated PTEN-/-LXR-/- Sham PTEN-/-LXR-/- Castrated.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
32 Samples
Download data: TSV
Series
Accession:
GSE134137
ID:
200134137
14.

A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer associated with clinical outcome.

(Submitter supplied) The propensity of cancer cells to transition between epithelial and mesenchymal phenotypic states is considered to be critical in metastatic processes, cancer progression, and treatment resistance. To investigate a transient epithelial-mesenchymal transition (EMT) in prostate adenocarcinoma, LNCaP cells with inducible and reversible expression of SNAI1 or SNAI2 were generated. Cells were treated with doxycycline to induce a SNAI1- or SNAI2-mediated EMT for 5 days and then subsequently removed for 3, 5, and 20 days to allow for MET. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16604
44 Samples
Download data: TXT
Series
Accession:
GSE80042
ID:
200080042
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