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Links from GEO DataSets

Items: 9

1.
Full record GDS4182

WHO 2008-classified acute myeloid leukemia subgroups (Analysis II): bone marrow mononuclear cells

Analysis of BMMCs from untreated patients with AML-MRC (AML with myelodysplasia-related changes) and from the combined group AML-NOS plus AML-MLD-sole on the basis of cytogenetics or a myelodysplastic syndrome (MDS) history. Results provide insight into the relevance of MLD for AML classification.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL570
Series:
GSE21261
96 Samples
Download data: CEL
DataSet
Accession:
GDS4182
ID:
4182
2.

Multilineage Dysplasia (MLD) in AML correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance

(Submitter supplied) Full Title: Multilineage Dysplasia (MLD) in AML correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: A comparison of 408 cases classified as “AML not otherwise specified” or “AML with myelodysplasia-related changes” The WHO classification of acute myeloid leukemia (AML) is hierarchically structured and integrates genetic information, data on patients’ history, and multilineage dysplasia (MLD). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS4181 GDS4182
Platform:
GPL570
96 Samples
Download data: CEL
Series
Accession:
GSE21261
ID:
200021261
3.
Full record GDS4181

WHO 2008-classified acute myeloid leukemia subgroups (Analysis I): bone marrow mononuclear cells

Analysis of BMMCs from untreated patients diagnosed as AML-MLD-sole (AML with myelodysplasia-related changes solely because of multilineage dysplasia) or AML-NOS (AML-not otherwise specified) according to WHO 2008 guidelines. Results provide insight into the relevance of MLD for AML classification.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL570
Series:
GSE21261
80 Samples
Download data: CEL
DataSet
Accession:
GDS4181
ID:
4181
4.

Multilineage dysplasia and AML with mutated nucleophosmin

(Submitter supplied) Multilineage dysplasia (MLD) has no impact on biological, clinico-pathological and prognostic features of AML with mutated nucleophosmin (NPM1) NPM1-mutated AML is a provisional entity in the WHO-2008 classification of myeloid neoplasms. The significance of concomitant multilineage dysplasia (MLD) in NPM1-mutated AML is unclear. Thus, in the WHO-2008 classification, NPM1-mutated AML with MLD is classified as AML with myelodysplasia(MD)-related changes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
48 Samples
Download data: CEL
Series
Accession:
GSE18018
ID:
200018018
5.

Multilineage dysplasia does not influence prognosis in patients with CEBPA mutated AML supporting the WHO proposal to classify these patients as a unique entity

(Submitter supplied) By WHO 2008, CEBPA-mutated AML became a provisional subentity, but it remains to be clarified how CEBPAmut AML with multilineage dysplasia (MLD; ≥50% dysplastic cells in 2-3 lineages) but no other MDS-related feature should be classified. We investigated 108 CEBPAmut AML (15.7-87.6 years) for the impact of MLD and genetic features. MLD-positive patients differed from MLD-negative only by lower mean WBC counts (p=0.004), but not by other blood values, biologic characteristics, cytogenetic risk profiles, or additional molecular markers (NPM1mut, FLT3-ITD/TKD, RUNX1, MLL-PTD, IDH1/2). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4407
Platform:
GPL570
30 Samples
Download data: CEL
Series
Accession:
GSE33223
ID:
200033223
6.
Full record GDS4407

Biallelic CEBPA-mutated acute myeloid leukemia with multilineage dysplasia: peripheral blood mononuclear cells

Analysis of PBMCs from biallelic CEBPA (encoding CCAAT/enhancer binding protein)-mutated, acute myeloid leukemia (AML) patients with or without multilineage dysplasia (MLD). Cases without CEBPA mutations also examined. Results provide insight into the classification of CEBPA-mutated AML patients.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 disease state, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE33223
30 Samples
Download data: CEL
DataSet
Accession:
GDS4407
ID:
4407
7.

Long non-coding RNA HOXB-AS3 promotes myeloid cell proliferation and its higher expression is an adverse prognostic marker in myeloid malignancies [MDS_normal]

(Submitter supplied) The mononucleated cells were collected from the bone marrow samples of MDS patients and healthy controls. We compared the expressions between MDS patients and the healthy controls.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
320 Samples
Download data: CEL
Series
Accession:
GSE114869
ID:
200114869
8.

Long non-coding RNA HOXB-AS3 promotes myeloid cell proliferation and its higher expression is an adverse prognostic marker in myeloid malignancies [AML_normal]

(Submitter supplied) The mononucleated cells were collected from the bone marrow samples of AML patients and healthy controls. We compared the expressions between AML patients and the healthy controls.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
214 Samples
Download data: CEL
Series
Accession:
GSE114868
ID:
200114868
9.

HOXB-AS3 expressions promote cell proliferation

(Submitter supplied) We knock down HOXB-AS3 with shRNA in OCI/AML3 cell line to investigate the downstream pathways of HOXB-AS3 in the cell proliferation.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
4 Samples
Download data: CEL
Series
Accession:
GSE114823
ID:
200114823
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