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Links from GEO DataSets

Items: 13

1.
Full record GDS4253

Lung epithelial cells response to lipopolysaccharide exposure

Analysis of laser-microdissected airway epithelial cells from snap-frozen lung 0 and 2 days after lipopolysaccharide (LPS) exposure. Inhalation of LPS can lead to chronic lung diseases like cystic fibrosis and asthma. Results provide insight into inflammatory mediators modulated by LPS exposure.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 time sets
Platform:
GPL85
Series:
GSE36174
6 Samples
Download data: CEL, CHP, TXT
2.

LPS-induced expression in rat lung epithelial cells

(Submitter supplied) Acute lung inflammation can alter the pulmonary function of susceptible individuals and exacerbate the pathogenesis of chronic inflammatory lung diseases including chronic obstructive pulmonary disease (COPD), cystic fibrosis and asthma. Exposure to lipopolysaccharide (LPS) or endotoxin, a constituent of outer cell membrane of gram negative bacteria, induces airway inflammation that is primarily characterized by increased polymorphonuclear neutrophils (PMNs) at early time points. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS4253
Platform:
GPL85
6 Samples
Download data: CEL, CHP, TXT
Series
Accession:
GSE36174
ID:
200036174
3.

IL-13 and EGF receptor signaling in normal human bronchial epithelial cells

(Submitter supplied) To investigate the role of interleukin-13 (IL-13) and the epidermal growth factor (EGF) receptor pathway in controlling mucus metaplasia, normal human bronchial epithelial (NHBE) cells were cultured on air-liquid interface for 14 days and were treated with IL-13, anti-EGFR antibody or both during the final 48 h of culture. Keywords: Stimulus response
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL3732
9 Samples
Download data: GPR
Series
Accession:
GSE4804
ID:
200004804
4.

Progressive human proteinuric nephropathies

(Submitter supplied) We obtained gene-expression profiles of microdissected renal-tubule cells from patients with proteinuric nephropathies. Based on the renal function during follow-up, the patients were divided in stable (n=14) and progressive (n=7) subjects (table 1). The cells of interest were laser-capture microdissected from frozen sections from archived kidney biopsy material. Initially all samples were processed as technical duplicates (2 x 21 arrays); due to a large number of signal-negative spots several arrays were excluded leaving 36 arrays for analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
4 related Platforms
36 Samples
Download data
Series
Accession:
GSE11513
ID:
200011513
5.

Effect of 10 Cigarette Smoke Condensates on Primary Human Airway Epithelial Cells

(Submitter supplied) Nine cigarette smoke condensates (CSCs) were produced under a standard ISO smoking machine regimen and one was produced by a more intense smoking machine regimen. These CSCs were used to treat primary normal human bronchial epithelial cells for 18 hours.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4917
Platform:
GPL570
22 Samples
Download data: CEL, CHP
Series
Accession:
GSE18235
ID:
200018235
6.
Full record GDS4917

Airway epithelial cell response to various cigarette smoke condensates

Analysis of primary airway epithelial cells treated for 18 hours with cigarette smoke condensates prepared from 5 commercial and 4 research cigarettes, at doses of about 4 ug/ml nicotine. Cigarettes vary in tobacco blend, filter ventilation, additives, and other physical and chemical properties.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 10 agent, 3 protocol sets
Platform:
GPL570
Series:
GSE18235
22 Samples
Download data: CEL, CHP
7.

POU2AF1 Functions in the Human Airway Epithelium to Regulate Expression of Host Defense Genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL11154 GPL570
193 Samples
Download data: CEL, CHP, FPKM_TRACKING
Series
Accession:
GSE77659
ID:
200077659
8.

POU2AF1 Functions in the Human Airway Epithelium to Regulate Expression of Host Defense Genes [array]

(Submitter supplied) In the process of seeking novel lung host defense regulators by analyzing genome-wide RNA sequence data from normal human airway epithelium, we detected expression of POU2AF1, a known transcription co-factor previously thought to be expressed only in lymphocytes. Lymphocyte contamination of human airway epithelial samples obtained by bronchoscopy and brushing was excluded by immunohistochemistry staining, the observation of up-regulation of POU2AF1 in purified airway basal stem/progenitor cells undergoing differentiation and analysis of differentiating single basal cell clones. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
184 Samples
Download data: CEL, CHP
Series
Accession:
GSE77658
ID:
200077658
9.

POU2AF1 Functions in the Human Airway Epithelium to Regulate Expression of Host Defense Genes [RNA-Seq]

(Submitter supplied) In the process of seeking novel lung host defense regulators by analyzing genome-wide RNA sequence data from normal human airway epithelium, we detected expression of POU2AF1, a known transcription co-factor previously thought to be expressed only in lymphocytes. Lymphocyte contamination of human airway epithelial samples obtained by bronchoscopy and brushing was excluded by immunohistochemistry staining, the observation of up-regulation of POU2AF1 in purified airway basal stem/progenitor cells undergoing differentiation and analysis of differentiating single basal cell clones. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
9 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE60989
ID:
200060989
10.

Ets homologous factor regulates pathways controlling response to injury in Calu-3 airway epithelial cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platform:
GPL11154
40 Samples
Download data: BED
Series
Accession:
GSE63400
ID:
200063400
11.

Ets homologous factor regulates pathways controlling response to injury in Calu-3 airway epithelial cells [DNAse-seq]

(Submitter supplied) Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithelial cell types including those lining the respiratory system. Disruption of the airway epithelium is central to many lung diseases, and a network of transcription factors coordinates its normal function. EHF can act as a transcriptional activator or a repressor, though its targets in lung epithelial cells are largely uncharacterized. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL11154
1 Sample
Download data: BED
12.

Ets homologous factor regulates pathways controlling response to injury in Calu-3 airway epithelial cells [ChIP-seq]

(Submitter supplied) Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithelial cell types including those lining the respiratory system. Disruption of the airway epithelium is central to many lung diseases, and a network of transcription factors coordinates its normal function. EHF can act as a transcriptional activator or a repressor, though its targets in lung epithelial cells are largely uncharacterized. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: BED
Series
Accession:
GSE63398
ID:
200063398
13.

Ets homologous factor regulates pathways controlling response to injury in Calu-3 airway epithelial cells [RNA-seq]

(Submitter supplied) Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithelial cell types including those lining the respiratory system. Disruption of the airway epithelium is central to many lung diseases, and a network of transcription factors coordinates its normal function. EHF can act as a transcriptional activator or a repressor, though its targets in lung epithelial cells are largely uncharacterized. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
33 Samples
Download data: DIFF
Series
Accession:
GSE63397
ID:
200063397
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