GEO DataSets

Analysis of heart, kidney, and lung from C57BL/6 males at 1, 4, 8 weeks of age. Mammalian somatic growth is rapid in early postnatal life but slows and eventually ceases in multiple tissues. Results provide insight into molecular events common to multiple tissues that regulate growth deceleration.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 time, 3 tissue sets

Platform:

GPL1261

Series:

GSE38754

40 Samples

Download data: CEL

(Submitter supplied) Temporal changes of gene expression from 1-wk- to 4-wk and 8-wk-old mouse in heart, kidney and lung. Mammalian somatic growth is rapid in early postnatal life but then slows and eventually ceases in multiple tissues. We hypothesized that there exists a postnatal gene expression program that is common to multiple tissues and is responsible for this coordinate growth deceleration. Consistent with this hypothesis, microarray analysis identified >1600 genes that were regulated with age coordinately in kidney, lung, and heart of juvenile mice, including many genes that regulate proliferation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4316

Platform:

GPL1261

40 Samples

Download data: CEL

(Submitter supplied) During early postnatal life, extensive changes in gene expression occur concomitantly in multiple major organs, indicating the existence of a common core developmental genetic program. This program includes hundreds of growth-promoting genes that are downregulated with age in liver, kidney, lung, and heart, and there is evidence that this component of the program drives the widespread decline in cell proliferation that occurs in juvenile life, as organs approach adult sizes. more...

Organism:

Mus musculus

Type:

Expression profiling by genome tiling array

Platform:

GPL5811

48 Samples

Download data: CEL, TXT

(Submitter supplied) Temporal changes of gene expression from 1-wk- to 5-wk-old rat in kidney and lung, and the effect of prior growth inhibition on these genetic changes. In mammals, body growth is rapid in early life but decelerates with age. Somatic growth deceleration is caused by a gradual decline in cell proliferation that occurs simultaneously in many different organs, but is not caused by a hormonal mechanism. We hypothesize that growth deceleration is driven by a postnatal genetic program that occurs coordinately in multiple organs. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

30 Samples

Download data: CEL

(Submitter supplied) The assembly of the developmentally arrested primordial follicle and subsequent transition to the primary follicle are poorly understood processes critical to ovarian biology. Abnormal primordial follicle development can lead to pathologies such as premature ovarian failure. The current study used a genome-wide expression profile to investigate primordial follicle assembly and development. Rat ovaries with predominantly unassembled, primordial, or primary follicles were obtained. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3006

Platform:

GPL85

6 Samples

Download data: CEL

Analysis of ovaries with unassembled, primordial, and primary follicles. Abnormal primordial follicle development can cause pathologies such as premature ovarian failure. Results provide insight into molecular mechanisms underlying primordial follicle assembly and transition to primary follicles.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 development stage, 3 protocol sets

Platform:

GPL85

Series:

GSE9300

6 Samples

Download data: CEL

(Submitter supplied) Non-coding microRNAs (miRNAs) mainly regulate the expression of targeted genes by regulating mRNA degradation or repressing their protein translation. MiRNA microarray profiling was then performed on 218 human HCC tumors samples, 10 samples from adjacent cirrhotic non-tumoral tissue, 10 samples from healthy liver and 12 HCC cell lines. In this study we investigated which miRNAs were differentially expressed in HCC compared to cirrhotic non-tumoral tissue and healthy liver.

Organism:

synthetic construct; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL14613

250 Samples

Download data: CEL

(Submitter supplied) Growth hormone (GH) is important in the development and maintenance of bone; however the IGF-dependent and -independent molecular pathways involved remain to be established. We used microarray analysis to identify genes acutely regulated by GH, in the bones of four week old GH-deficient mice at 6 or 24 hours following a single injection of GH (4 mg/kg body wt) or PBS (n = 6/group). 6,160 genes were differentially expressed at P = 0.05 and 17% of these genes were identified at both time points. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1929

Platform:

GPL922

6 Samples

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Analysis of femurs and tibias of growth hormone (GH) deficient animals at 6 and 24 hours following treatment with 4 mg/kg body weight GH. Results provide insight into the insulin-like growth factor-I dependent and independent pathways that mediate the action of GH in bone.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 2 time sets

Platform:

GPL922

Series:

GSE3689

6 Samples

Download data

(Submitter supplied) Gene expression profiling has provided critical insights into the molecular pathways underlying development of model organisms, however little information is available on regulated gene expression during human embryogenesis. We have now filled this important gap of knowledge by performing genome-wide microarray analysis of the Homo sapiens gene expression during the 4-9th week, a period when most organs develop. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

18 Samples

Download data: CEL

(Submitter supplied) To investigate the altered genes by RacGAP1 silencing

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

Download data: CEL

(Submitter supplied) Fetal lung development is a complex biological process, which involves temporal and spatial regulations of many genes. To understand molecular mechanisms of this process, we investigated gene expression profiling of lungs at gestational day 18, 19, 20, 21, new born, and adult rats using in-house rat DNA microarray containing 6,000 known genes and 4,000 ESTs. 1,512 genes passed SAM test and 583 genes (402 known genes and 181 ESTs) had a 2-fold change at least at one time point. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1699

54 Samples

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(Submitter supplied) Body size varies enormously among mammalian species. In small mammals, body growth is typically suppressed rapidly, within weeks, whereas in large mammals, growth is suppressed slowly, over years, allowing for a greater adult size. We recently reported evidence that body growth suppression in rodents is caused in part by a juvenile genetic program that occurs in multiple tissues simultaneously and involves the downregulation of a large set of growth-promoting genes. more...

Organism:

Bos taurus; Ovis aries

Type:

Expression profiling by array

Platform:

GPL2112

30 Samples

Download data: CEL, CHP

(Submitter supplied) Studies from our laboratory have demonstrated that treatment of adult male rats with tamoxifen, a selective estrogen receptor modulator, at a dose of 0.4 mg/kg/day for 60 days resulted in an increase in post-implantation loss at around mid gestation. The present study was done to assess global gene expression profile using Agilent Rat Whole Genome Microarray slides. Differential gene expression profile of resorbed to normal embryos at embryonic day (E) 11 and 13 was studied to identify the causes of resorption. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7294

6 Samples

Download data: TXT

(Submitter supplied) To explore the mechanisms responsible for spatial and temporal regulation of the growth plate, we microdissected postnatal rat growth plates into their constituent zones and then used microarray analysis to characterize the changes in gene expression that occur as chondrocytes undergo spatially-associated differentiation and temporally-associated senescence.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

35 Samples

Download data: CEL

(Submitter supplied) Microarray analysis of male and female CD-1 mouse liver was carried out at 3, 4, and 8 wk of age to elucidate developmental changes in gene expression from the pre-pubertal period to young adulthood. A large number of sex-biased and sex-independent genes showed significant changes during this developmental period. Notably, sex-independent genes involved in cell cycle, chromosome condensation, and DNA replication were down regulated from 3 wk to 8 wk, while genes associated with metal ion binding, ion transport and kinase activity were up regulated. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10333

14 Samples

Download data: TXT