GEO DataSets

Analysis of primary macrophages from three donors (D1, D2, D3) up to 6 hrs after in vitro exposure to purified Zaire ebolavirus (ZEBOV) virions. ZEBOV is the etiological agent of Ebola Hemorrhagic Fever (EHF). Results provide insight into the initial response of macrophages exposed to Ebola virions.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 individual, 2 infection, 2 time sets

Platform:

GPL8300

Series:

GSE31747

12 Samples

Download data: CEL, CHP

(Submitter supplied) Zaire ebolavirus (ZEBOV) infections are associated with high lethality in primates. ZEBOV primarily targets mononuclear phagocytes, which are activated upon infection and secrete mediators believed to trigger initial stages of pathogenesis. The characterization of the responses of target cells to ZEBOV infection may therefore not only further understanding of pathogenesis but also suggest possible points of therapeutic intervention. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4356

Platform:

GPL8300

12 Samples

Download data: CEL, CHP

(Submitter supplied) To elucidate the mechanisms involved in pulmonary inflammation in Zaire ebolavirus-infected pigs, lung sections infected pigs were used for a porcine microarray to analyse changes in gene expression with particular interest in proinflammatory cytokine and chemokine transcription.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL10162

16 Samples

Download data: PDF, PNG, TXT, XLS

(Submitter supplied) Highly pathogenic Zaire ebolavirus (EBOV) infection is associated with a dysregulated immune response and high levels of cytokines and chemokines are observed in fatal human cases. . In stark contrast Reston ebolavirus (RESTV) might be non-pathogenic for humans yet the underlying mechanisms determining pathogenicity for different Ebola viruses are not understood. In this study we investigate antiviral immune responses in EBOV- and RESTV- infected primary human monocyte-derived macrophages (MDM). more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

42 Samples

Download data: CSV, TXT