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Links from GEO DataSets

Items: 17

1.
Full record GDS4462

Endothelial cells from P8 neonatal retina [MG_U74Bv2]

Analysis of FACS-sorted, GFP-positive endothelial cells from retinas of postnatal day 8 (P8) homozygous Tie2-GFP transgenics. Deregulated retinal angiogenesis causes vision loss in many ocular diseases. Results provide insight into the molecular mechanisms underlying intraretinal angiogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 cell type sets
Platform:
GPL82
Series:
GSE27238
6 Samples
Download data: CEL
2.

FACS-array profiling in retinal endothelial cells from living mouse retinas without pericyte coverage

(Submitter supplied) Pericytes confer vascular stability in the retina, and the loss of pericytes can cause the blood-retina barrier breakdown seen in diabetic retinopathy. To identify endothelial-specific genes expressed in pericyte-deprived retinal vessels, we purified genetically labeled endothelial cells from Tie2-GFP transgenic mice treated with neutralizing antibody against PDGFRb (APB5) and performed gene expression profiling using DNA microarray. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL82 GPL83 GPL81
9 Samples
Download data: CEL
Series
Accession:
GSE86819
ID:
200086819
3.

FACS-array profiling in retinal endothelial cells from living mouse retinas

(Submitter supplied) Deregulated retinal angiogenesis directly cause vision loss in many ocular diseases, such as diabetic retinopathy and retinopathy of prematurity. To identify endothelial-specific genes expressed in angiogenic retinal vessels, we purified genetically labeled endothelial cells from Tie2-GFP transgenic mice and performed gene expression profiling using DNA microarray. To find out genes associated with angiogenesis, comparisons of microarray data were carried out between GFP-negative non-endothelial retinal cells and GFP-positive retinal endothelial cells in angiogenic P8 retina.
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS4461 GDS4462 GDS4463
Platforms:
GPL82 GPL81 GPL83
18 Samples
Download data: CEL
Series
Accession:
GSE27238
ID:
200027238
4.
Full record GDS4463

Endothelial cells from P8 neonatal retina [MG_U74Cv2]

Analysis of FACS-sorted, GFP-positive endothelial cells from retinas of postnatal day 8 (P8) homozygous Tie2-GFP transgenics. Deregulated retinal angiogenesis causes vision loss in many ocular diseases. Results provide insight into the molecular mechanisms underlying intraretinal angiogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 cell type sets
Platform:
GPL83
Series:
GSE27238
6 Samples
Download data: CEL
5.
Full record GDS4461

Endothelial cells from P8 neonatal retina [MG_U74Av2]

Analysis of FACS-sorted, GFP-positive endothelial cells from retinas of postnatal day 8 (P8) homozygous Tie2-GFP transgenics. Deregulated retinal angiogenesis causes vision loss in many ocular diseases. Results provide insight into the molecular mechanisms underlying intraretinal angiogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 cell type sets
Platform:
GPL81
Series:
GSE27238
6 Samples
Download data: CEL
6.

Endothelial cell-enriched genes expression in mouse embryo

(Submitter supplied) The early blood vessels of the embryo and yolk sac in mammals develop by aggregation of de novo forming angioblasts into a primitive vascular plexus, which then undergoes a complex remodeling process. Angiogenesis is also important for disease progression in the adult. However, the precise molecular mechanism of vascular development remains unclear. It is therefore of great interest to determine which genes are specifically expressed in developing endothelial cells.Here, we utilized Flk1-deficient mouse embryos, which lack endothelial cells, to perform a genome-wide survey for genes related to vascular development.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE37431
ID:
200037431
7.

Gene Expression Analysis of 4T1 orthotopic tumors in PDGFRb-TK mice

(Submitter supplied) Analysis of the gene expression level of 4T1 orthotopic tumors in mice with and without pericyte depletion.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6887 GPL6885
13 Samples
Download data: TXT
Series
Accession:
GSE55785
ID:
200055785
8.

Retinal gene expression in Egr-1 knock-out mice during development (p30 and p42)

(Submitter supplied) In chicks, the avian homologue of the early growth response protein-1 (ZENK) has been shown to be increased in a special cell type of the retina, the glucagonergic amacrine cells, under conditions that lead to a reduction in eye growth (myopic defocus, recovery of myopia) and decreased under conditions that enhance ocular growth (hyperopic defocus, form-deprivation). The investigation of Egr-1 knock-out mice showed that homozygous knock-out mice with no functional Egr-1 protein developed relative axial myopia at the age of 42 and 56 days, compared to heterozygous- and wildtype Egr-1 knock-out mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3607
Platform:
GPL1261
16 Samples
Download data: CEL
Series
Accession:
GSE16974
ID:
200016974
9.
Full record GDS3607

Egr-1 deficiency effect on retina during eye development

Analysis of retinas of Egr-1 deficient animals at post-natal days 30 and 42. 42 day-old Egr-1 knockout animals have longer eyes and a more myopic refractive error compared to wild-types. Results provide insight into the molecular mechanisms regulating axial eye growth.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE16974
16 Samples
Download data: CEL
10.

Effect of VEGF on expressions of C2H2 zinc finger proteins in human umbilical vein endothelial cells.

(Submitter supplied) Angiogenic homeostasis is maintained by a balance between vascular endothelial growth factor (VEGF) and Notch signalling in endothelial cells (ECs). We screened for molecules that might mediate the coupling of VEGF signal transduction with down-regulation of Notch signalling, and identified B-cell chronic lymphocytic leukemia/lymphoma6-associated zinc finger protein (BAZF). BAZF was induced by VEGF-A in ECs to bind to the Notch signalling factor CBF1, and to promote the degradation of CBF1 through polyubiquitination in a CBF1-cullin3 (CUL3) E3 ligase complex. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15142
7 Samples
Download data: TXT
Series
Accession:
GSE35171
ID:
200035171
11.

Perivascular Progenitor Cells Derived from Human Embryonic Stem Cells Exhibit Functional Characteristics of Pericytes, and Improve the Retinal Vasculature in a Rodent Model of Diabetic Retinopathy

(Submitter supplied) Diabetic retinopathy (DR) is the leading cause of blindness in working-age people. Pericyte loss is one of the pathologic cellular events in DR, which weakens the retinal microvessels. Damages to the microvascular networks are irreversible and permanent, thus further progression of DR is inevitable. In this study, we hypothesize that multipotent perivascular progenitor cells derived from human ESCs (hESC-PVPCs) improve the damaged retinal vasculature in the streptozotocin (STZ)-induced diabetic rodent models. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
9 Samples
Download data: TXT
Series
Accession:
GSE77114
ID:
200077114
12.

Expression data from co- and mono-cultured human brain microvascular endothelial cells and human brain vascular pericytes treated with and without estradiol

(Submitter supplied) For the formation of the blood-brain barrier not only endothelial cells alone, but also their interaction with surrounding cell types, like pericytes, plays an important role, and co-culture of the two cell types increases barrier function in vitro. Furthermore, observed sex differences with regard to several cardiovascular as well as neurodegenerative disorders have led to the hypothesis that the female sex hormone estrogen might protect from endothelial barrier break-down. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23159
24 Samples
Download data: CEL, TXT
Series
Accession:
GSE168514
ID:
200168514
13.

Correlating global gene regulation to morphogenesis and maturation in the chick extra-embryonic vascular system

(Submitter supplied) Formation of blood vessels requires the concerted regulation of an unknown number of genes in a spatial-, time- and dosage-dependent manner. We investigated vascular development in vivo by determining global gene regulation throughout the formation of the chick chorio-allantoic membrane (CAM). Our study provides a comprehensive molecular map of vascular maturation during developmental angiogenesis and might thus be a valuable resource to streamline further research of candidates susceptible to mediate pathological angiogenesis.
Organism:
Gallus gallus
Type:
Expression profiling by array
Platform:
GPL3213
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE11636
ID:
200011636
14.

Actively translating transcriptome (Ribotag) profiling of mouse retinal endothelial cells during postnatal development

(Submitter supplied) Angiogenesis, a process mediating the expansion of vascular beds in many physiological and pathological settings, requires dynamic changes in endothelial cell (EC) behavior. The molecular mechanisms governing EC activity during different phases of vascular growth, remodeling, maturation, and quiescence remain elusive. Here, we have employed actively translating transcriptome analysis of mouse retinal ECs for the characterization of dynamic gene expression changes during postnatal development and the identification of critical angiogenic factors. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL16417
20 Samples
Download data: TXT, XLSX
Series
Accession:
GSE86788
ID:
200086788
15.

Sox18 regulated genes

(Submitter supplied) Study of Sox18 regulated genes: Human umbilical vein endothelial cells (HUVEC) were either transduced with adenoviral vectors expressing SOX18 from an IRES-EGFP casette, or IRES-EGFP alone, or left untreated. After 16 hours, mRNA was isolated and analyzed by hybridization to Affymetrix HG-U133A arrays.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
3 Samples
Download data: CEL
Series
Accession:
GSE8952
ID:
200008952
16.

Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis

(Submitter supplied) Chip-Seq on HEK293 cells using an antibody against PAR2 in order to determe binding to promoter and enhancer sequences
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL10999
1 Sample
Download data: TXT
Series
Accession:
GSE58660
ID:
200058660
17.

The precursors of hematopoietic stem cells during mouse embryogenesis

(Submitter supplied) Definitive hematopoietic stem cells (HSCs) bud off from the hemogenic endothelial cells (HEC) located in the dorsal aorta of the mouse embryo. The maturation of HSCs from HEC occurs through the precursor of HSCs (pre-HSCs) between embryonic day (E) 9.5 and E11.5. To clarify the differentiation process of pre-HSCs, we performed single-cell RNA-seq analysis of cells dissociated from the dorsal aorta and its surrounding tissues and the fetal liver at E10.5 and E11.5. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21273
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE167932
ID:
200167932
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