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Links from GEO DataSets

Items: 6

1.
Full record GDS4488

Notch1 signaling inhibition effect on aortic valve interstitial cells

Analysis of aortic valve interstitial cells treated with the Notch1 signaling inhibitor DAPT. NOTCH1 mutations are associated with aortic valve malformations and adult-onset calcification. Results provide insight into the role of Notch in the pathogenesis of calcific aortic valve disease.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL1355
Series:
GSE31668
6 Samples
Download data: CEL
2.

Inhibitory Role of Notch1 in Calcific Aortic Valve Disease

(Submitter supplied) Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown. NOTCH1 mutations are associated with aortic valve malformations and adult-onset calcification in families with inherited disease. The Notch signaling pathway is critical for multiple cell differentiation processes, but its role in the development of CAVD is not well understood. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS4488
Platform:
GPL1355
6 Samples
Download data: CEL
Series
Accession:
GSE31668
ID:
200031668
3.

Characterization of Heart Valve Leaflets from Adult and Juvenile Rapacz Familial Hypercholesterolemic Swine

(Submitter supplied) Rapacz Familial Hypercholesterolemic (RFH) swine have been used extensively in the vascular biology field as a robust model of complex atherosclerotic lesions. However, the heart valves from RFH swine have not been evaluated and it is unknown whether these animals develop calcific aortic valve disease without dietary intervention. Histological assessment of heart valve leaflets isolated from juvenile and adult swine revealed RFH swine develop the early hallmarks of the disease at two years of age. more...
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL3533
10 Samples
Download data: CEL
Series
Accession:
GSE53997
ID:
200053997
4.

Raloxifene Attenuates Gas6 and Apoptosis in Experimental Aortic Valve Disease in Renal Failure

(Submitter supplied) Introduction: Renal failure is associated with aortic valve calcification. Using our rat model of uraemia-induced reversible aortic valve calcification, we assessed the role of apoptosis and survival pathways in aortic valve calcification. We also explored the effects of raloxifene - an estrogen receptor modulator on valvular calcification. Methods: Gene array analysis was performed in aortic valves obtained from 3 groups of rats (n=7 each): calcified valves from rats fed with uremic diet -high-adenine (0.75%), high-phosphate diet (1.5%), valves after calcification resolution following diet cessation (reversibility) and control. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL16305
4 Samples
Download data: GPR
Series
Accession:
GSE21771
ID:
200021771
5.

Gene expression in aortic roots of wild type versus klotho-deficient mice at 6 weeks of age

(Submitter supplied) Klotho-deficient mice develop aortic valve annulus calcification by 6 weeks of age. Understanding the molecular basis by which aortic valve calcification is initiated will help define potential molecular targets which may be inhibited to reduce or prevent aortic valve calcification. Changes in gene expression related to aortic valve annulus calcification were analyzed by comparing gene expression in the aortic roots from wild type versus klotho-deficient mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE52794
ID:
200052794
6.

Gene expression from healthy male and female porcine aortic valve leaflets

(Submitter supplied) Calcific aortic valvular disease (CAVD) is characterized by sclerosis of the aortic valve leaflets and recent clinical studies have linked several other risk factors to this disease, including male sex. In this study we examined potential sex-related differences in gene expression profiles between porcine male and female valvular interstitial cells (VICs) to explore possible differences in CAVD propensity on the cellular level.
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL3533
6 Samples
Download data: CEL
Series
Accession:
GSE33654
ID:
200033654
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