GEO DataSets

Analysis of third instar wing disc from EGFR dominant negative (71B-Gal4; UAS EgfrDN) and EGFR activated (71B-GAL4; UAS EgfrACT) larvae. Aberrant signaling of highly conserved EGFR pathway is implicated in a number of diseases. Results provide insight into the identity of new EGFR-responsive genes.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL72

Series:

GSE34872

6 Samples

Download data: CEL

(Submitter supplied) The highly conserved Epidermal Growth Factor-receptor (Egfr) pathway is required in all animals for normal development and homeostasis; consequently, aberrant Egfr signaling is implicated in a number of diseases. Genetic analysis of Drosophila melanogaster Egfr has contributed significantly to understanding this conserved pathway and has led to the discovery of new components and targets. Here we used microarray analysis of Drosophila third instar wing discs, in which Egfr signaling was perturbed, to identify new Egfr-responsive genes. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS4496

Platform:

GPL72

6 Samples

Download data: CEL

(Submitter supplied) During Drosophila melanogaster oogenesis, the JAK/STAT and EGFR pathways are both required to specify a population of somatic epithelial cells called the posterior follicle cells (PFCs). The PFCs are important because they generate a signal at mid-oogenesis that is required to establish the embryonic axes. To identify novel PFC-expressed transcripts, egg chambers containing ectopic PFCs were generated and microarrays were then used to identify upregulated transcripts. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL17080

6 Samples

Download data: TXT

(Submitter supplied) The absent, small or homeotic discs 2 (ash2) gene, a member of the trithorax Group (trxG) of transcriptional regulators, is functionally related to ash1. However, ASH2 and ASH1 belong to distinct multimeric complexes of unknown composition and it is unclear how they act to regulate transcription. In this study, examination of gene expression profiles in wing imaginal discs from ash2 and ash1 mutants revealed their transcriptomes are very similar and correlate with wing phenotypes. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL3797

12 Samples

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