GEO DataSets

Analysis of whole skin from female, K5cre-caNrf2 transgenics at P2.5. Nrf2 activation induced epidermal thickening and hyperkeratosis resembling human skin disease lamellar ichthyosis. Results provide insight into the role of Nrf2 as a regulator of protective functions of the epidermis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE35160

6 Samples

Download data: CEL

(Submitter supplied) The Nrf2 transcription factor is a key player in the cellular stress response, which regulates the expression of important antioxidant enzymes and other cytoprotective proteins. We recently generated a novel transgenic mouse model to determine the function of Nrf2 in the skin. These mice revealed interesting phenotypic abnormalities, including hyperkeratosis and acanthosis. To gain insight into the underlying molecular mechanisms, we wanted to identify genes, which are differentially expressed in the skin of wild-type and mutant mice before the onset of phenotypic abnormalities.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4498

Platform:

GPL1261

6 Samples

Download data: CEL

(Submitter supplied) Investigation of gene expression in human skin keratinocytes (HaCaT) following non-thermal plasma treatment for 20 s, 60 s, and 180 s compared to untreated and H2O2-treated controls. Microarrays were used to analyze and investigate the biological effects of non-thermal plasma on human keratinocyte cells. Using an argon plasma jet kinpen, regulated transcripts were analyzed and further described in Schmidt et al. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8971

38 Samples

Download data: PAIR

(Submitter supplied) Unveiling the molecular mechanisms underlying tissue regeneration provides new opportunities to develop treatments for diabetic ulcers and other chronic skin lesions. Here, to gain insight into critical wound response mechanisms regulated by epidermal Nrf2, we micro dissected a ~2.5mm concentric ring around the 10mm wound at 5 days-post-wounding (DPW) and used flow cytometry to isolate wound-associated keratinocytes from Nrf2 +/+ Ker and Nrf2 ∆/∆ Ker mice for bulk RNA-seq. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

5 Samples

Download data: XLSX

(Submitter supplied) Using RNA-sequencing we tested how human sebaceous glands cells respond to bacterial stimuli by comparing the mRNA profiles of sebaceous gland cells treated with lipopolysaccharide to vehicle treated sebaceous gland cells.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

6 Samples

Download data: TXT