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Links from GEO DataSets

Items: 7

1.
Full record GDS4527

Atherosclerosis susceptibility model: macrophages

Analysis of macrophages from C57BL/6.MOLFc4(51Mb)-Ldlr-/- mice. This model harbors an atherosclerosis susceptibility locus and the region homologous to the human 9p21 locus associated with coronary artery disease. Results provide insight into the molecular basis of increased atherosclerotic risk.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL9734
Series:
GSE24342
20 Samples
Download data: CEL
2.

Athsq1 is linked to Cdkn2a

(Submitter supplied) Common genetic variants in a 58-kilobase (kb) region of chromosome 9p21, near the CDKN2A/B cell proliferation inhibitor genes, are strongly associated with coronary artery disease (CAD). We previously reported a congenic mouse model harboring an atherosclerosis susceptibility locus in a region of homology with the human 9p21 locus. We now report markedly decreased Cdkn2a (cyclin-dependent kinase inhibitor 2a) mRNA expression in macrophages and increased circulating levels of Ly6Chigh inflammatory monocytes in congenic mice compared to controls. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4527
Platform:
GPL9734
40 Samples
Download data: CEL
Series
Accession:
GSE24342
ID:
200024342
3.

Comparison of gene expression in aorta and CD115+ isolated circulating cells from apoE-/- versus apoE-/-LTbR-/- mice

(Submitter supplied) Affymetrix Microarrays were used to analyse gene expression in aortas and circulating CD115+ cells of ApoE- and ApoE/Lymphotoxin beta receptor (LTbR)-double-deficent mice fed a Western diet from 8 to 12 weeks of age in order to identify regulated genes and pathways leading to reduced atherosclerosis in ApoE-/-/LTbR-/- mice compared to ApoE-/- littermate controls.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
14 Samples
Download data: CEL
Series
Accession:
GSE63259
ID:
200063259
4.

Suppressor of cytokine signaling 1 is involved in gene regulation which control the survival of Ly6Clow monocytes in mice

(Submitter supplied) Objective: Monocytes are crucially involved in inflammatory processes. In mice, different subsets of monocytes can be distinguished by the expression of Ly6C, a surface marker that is highly expressed on inflammatory monocytes (Ly6C high) and to a lesser extent on patrolling monocytes (Ly6C low). Our previous study revealed an aggravated accumulation of inflammatory Ly6C high monocytes in atherosclerotic-prone mice bearing a deficiency in suppressor of cytokine signaling (Socs)-1. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18752
33 Samples
Download data: IDAT, TXT
Series
Accession:
GSE103705
ID:
200103705
5.

Deep phenotyping by mass cytometry and single cell RNA-sequencing reveals LYN regulated signaling profiles underlying monocyte subset heterogeneity and lifespan

(Submitter supplied) Rationale: Monocytes are key effectors of the mononuclear phagocyte system (MPS), playing critical roles in regulating tissue homeostasis and coordinating inflammatory reactions, including those involved in chronic inflammatory diseases such as atherosclerosis. Monocytes have traditionally been divided into two major subsets termed conventional (cMo) and patrolling (pMo) monocytes but recent systems immunology approaches have identified marked heterogeneity within these cells, and much of what regulates monocyte population homeostasis remains unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
2 Samples
Download data: CSV
Series
Accession:
GSE146216
ID:
200146216
6.

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans.

(Submitter supplied) Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their role in human health and disease remains obscure. Here, we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome 9p21, confers athero-protection by controlling ribosomal RNA (rRNA) maturation and modulating pathways of atherogenesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
6 Samples
Download data: IDAT, TXT
Series
Accession:
GSE65392
ID:
200065392
7.

The MTAP-CDKN2A Locus Confers Susceptibility to a Naturally Occurring Canine Cancer

(Submitter supplied) Well-defined, closed breeding populations coupled with excessive disease predispositions among purebred domestic dog breeds offer unique advantages to genetic studies of disease susceptibility. Advantages offered by canine population substructure, combined with similarity to human disease in terms of clinical presentation and response to treatment, make the dog a particularly attractive system for finding genes associated with cancer. more...
Organism:
Canis lupus familiaris
Type:
SNP genotyping by SNP array
Platform:
GPL15578
474 Samples
Download data: TXT
Series
Accession:
GSE38011
ID:
200038011
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