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Links from GEO DataSets

Items: 7

1.
Full record GDS4563

Passive loading effect on gastrocnemius muscle of intensive care unit model: time course

Temporal analysis of loaded leg gastrocnemius of females (subjected to neuromuscular blockade, mechanical ventilation) following unilateral passive mechanical loading (PML). Results provide insight into molecular basis of the beneficial effects of PML on muscle mass and function in this ICU model.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 protocol, 3 time sets
Platform:
GPL6247
Series:
GSE37944
46 Samples
Download data: CEL
2.

Sparing of muscle mass and function by passive loading in an experimental intensive care unit model

(Submitter supplied) Critically ill intensive care unit (ICU) patients commonly develop severe muscle wasting and impaired muscle function, leading to delayed recovery, with subsequent increased morbidity and financial costs, and decrease quality of life of survivors. Acute Quadriplegic Myopathy (AQM) is one of the most common neuromuscular disorders associated with ICU-acquired muscle weakness. Although there are no available treatments for the ICU-acquired muscle weakness, it has been demonstrated that early mobilization can improve its prognosis and functional outcomes. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS4563
Platform:
GPL6247
46 Samples
Download data: CEL
Series
Accession:
GSE37944
ID:
200037944
3.

The role of sepsis in the development of limb muscle weakness in a porcine ICU model

(Submitter supplied) Background : The aim of this study is to improve our understanding of the mechanisms underlying the role of sepsis in the limb muscles of ICU patients with acute quadriplegic myopathy (AQM) by using a unique porcine ICU model, i.e., 5-day longitudinal experiments where animals are sedated, mechanically ventilated and exposed to factor triggering AQM that is endotoxin-induced sepsis. Results : An increased expression of genes involved in chemokine activity and transcriptional regulation. more...
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL3533
8 Samples
Download data: CEL
Series
Accession:
GSE33037
ID:
200033037
4.

Muscle wasting and the temporal gene expresion pattern in a novel rat ICU model

(Submitter supplied) Acute quadriplegic myopathy (AQM) or critical illness myopathy (CIM) is frequently observed in intensive care unit (ICU) patients. In order to elucidate duration-dependent effects of the ICU intervention on molecular and functional networks that control the muscle wasting and weakness in AQM, gene expression profile was analyzed at time points varying from 6 hours to 14 days in a unique experimental rat model mimicking ICU conditions, i.e., post-synaptically paralyzed, mechanically ventilated and extensively monitored animals.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
28 Samples
Download data: CEL, TXT
Series
Accession:
GSE30848
ID:
200030848
5.

Gene expression and muscle fiber function in a porcine ICU model

(Submitter supplied) Background: Skeletal muscle wasting and impaired muscle function in response to mechanical ventilation and immobilization in intensive care unit (ICU) patients are clinically challenging partly due to (i) the poorly understood intricate cellular and molecular networks; and (ii) the unavailability of an animal model mimicking this condition. By employing a unique porcine model mimicking the conditions in the ICU with long-term mechanical ventilation and immobilization, we have analyzed the expression profile of skeletal muscle biopsies taken at three time points during a five-day period. more...
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL3533
24 Samples
Download data: CEL, CHP
Series
Accession:
GSE16348
ID:
200016348
6.

Mechanisms underlying the sparing of masticatory muscle function relative to biceps femoris muscle in an experimental critical illness model

(Submitter supplied) Background: The aim of this study is to improve our understanding of the mechanisms underlying the sparing of masticatory muscles relative to limb muscles in ICU patients with acute quadriplegic myopathy (AQM) by using a unique porcine ICU model, i.e., 5-day longitudinal experiments where animals are sedated, mechanically ventilated and exposed to factors triggering AQM, such as muscle unloading, endotoxin-induced sepsis, and systemic exposure to CS and NMBA. more...
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL3533
18 Samples
Download data: CEL, TXT
Series
Accession:
GSE24239
ID:
200024239
7.

Transcriptional response of rat skeletal muscle to prolonged fasting

(Submitter supplied) Prolonged fasting-induced changes in rat tibialis anterior muscle transcriptome Skeletal muscle is of primary importance for metabolism, thermogenesis and locomotion. However, muscle integrity is inevitably challenged throughout life, and muscle atrophy occurs in various situations, being associated with development of metabolic diseases. There is virtually no fully effective countermeasure today to fight the loss of muscle mass. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
9 Samples
Download data: CEL, CHP
Series
Accession:
GSE149829
ID:
200149829
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