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Links from GEO DataSets

Items: 13

1.
Full record GDS4579

Subchronic silicosis model: whole lung

Analysis of lung at 28 wk following subchronic silica inhalation exposure to occupationally relevant doses and particle sizes of aerosolized silica. Results provide insight into molecular events associated with chronic silicosis.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL1355
Series:
GSE29110
6 Samples
Download data: CEL
2.

Fibrogenic and redox-related but not proinflammatory genes are upregulated in lewis rat model of chronic silicosis

(Submitter supplied) Silicosis, a fibrotic granulomatous lung disease, may occur through accidental high-dose or occupational inhalation of silica, leading to acute/accelerated and chronic silicosis, respectively. While chronic silicosis has a long asymptomatic latency, lung inflammation and apoptosis are hallmarks of acute silicosis. In animal models, histiocytic granulomas develop within days after high-dose intratracheal silica instillation. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS4579
Platform:
GPL1355
6 Samples
Download data: CEL
Series
Accession:
GSE29110
ID:
200029110
3.

Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats

(Submitter supplied) Identification of molecular target(s) and mechanism(s) of silica-induced pulmonary toxicity is important for the intervention and/or prevention of diseases associated with occupational exposure to crystalline silica. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 h/day, 5 days) and global gene expression profile was determined in the lungs by microarray analysis at 1, 2, 4, 8, and 16 weeks following termination of silica exposure. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
60 Samples
Download data: TXT
Series
Accession:
GSE32147
ID:
200032147
4.

Gene expression profiles in rat lung following intratracheal instillation with C60 fullerene particles

(Submitter supplied) Gene expression profiling of the rat lung following intratracheal instillation with C60 fullerene particles was employed to gain insights into these molecular events.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL7294
22 Samples
Download data: TXT
Series
Accession:
GSE17747
ID:
200017747
5.

Gene expression profiles in rat lung following intratracheal instillation with single-wall carbon nanotubes

(Submitter supplied) Gene expression profiling of the rat lung following intratracheal instillation with single-wall carbon nanotubes (SWCNTs) was employed to gain insights into these molecular events. We attempted to characterize time-dependent changes in the gene expression until 754 days after intratracheal instillation with SWCNTs suspensions at 0.2 mg (L-SWCNT) and 0.4 mg (H-SWCNT) injected dose per rat, and to identify the shift from the acute-phase to the chronic-phase phase on the basis of evaluation at the molecular level.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL7294
21 Samples
Download data: TXT
Series
Accession:
GSE50664
ID:
200050664
6.

Gene expression response to silica treatment in wild-type C57 black 6 mice vs Rag1 knockout, NK-depleted mice

(Submitter supplied) The lung is constantly exposed to potentially pathogenic particles and microorganisms. It has recently become evident that not only innate, but also adaptive immune responses to particulates such as crystalline silica (SiO2) entering the respiratory tract are complex and dynamic events. Although the cellular mechanisms and anatomical consequences involved in the development of silicosis have been extensively studied, they still remain poorly understood. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
8 Samples
Download data: GPR
Series
Accession:
GSE19563
ID:
200019563
7.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6947 GPL6101
80 Samples
Download data
Series
Accession:
GSE30216
ID:
200030216
8.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling (A549 cells dataset 5)

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
10 Samples
Download data: TXT
Series
Accession:
GSE30215
ID:
200030215
9.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling (A549 cells dataset 4)

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
10 Samples
Download data: TXT
Series
Accession:
GSE30214
ID:
200030214
10.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling (A549 cells dataset 3)

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
10 Samples
Download data: TXT
Series
Accession:
GSE30213
ID:
200030213
11.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling (A549 cells dataset 2)

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
20 Samples
Download data: TXT
Series
Accession:
GSE30200
ID:
200030200
12.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling (A549 cells dataset 1)

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
10 Samples
Download data: TXT
Series
Accession:
GSE30180
ID:
200030180
13.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling (rat lungs)

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
20 Samples
Download data: TXT
Series
Accession:
GSE30178
ID:
200030178
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