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Links from GEO DataSets

Items: 15

1.
Full record GDS4621

Mutated anaplastic lymphoma kinase-driven neuroblastoma model

Analysis of neuroblastomas (NB) induced by mutated anaplastic lymphoma kinase (ALKF1174L), MYCN, or both oncogenes. ALK is a gene normally expressed in the developing nervous system. Results provide insight into the role of mutated ALK in tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 4 genotype/variation, 2 tissue sets
Platform:
GPL1261
Series:
GSE32386
13 Samples
Download data: CEL
DataSet
Accession:
GDS4621
ID:
4621
2.

Expression profiling of murine neuroblastoma in transgenic mice

(Submitter supplied) Neuroblastoma is an embryonal tumor arising from the neural crest. It can be mimicked in mice by neural crest-specific overepxression of oncogenes such as MYCN or mutated ALK.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4621
Platform:
GPL1261
13 Samples
Download data: CEL
Series
Accession:
GSE32386
ID:
200032386
3.

Transcriptional profiles of transgenic ALK^F1174L/MYCN vs. MYCN tumors

(Submitter supplied) The ALK^F1174L mutation is associated with intrinsic and acquired resistance to crizotinib and cosegregates with MYCN in neuroblastoma. In this study, we generated a mouse model overexpressing ALK^F1174L in the neural crest. Comapred to mice expressing ALK^F1174L or MYCN alone, combined expression of the two aberrations led to development of neuroblastoma with a shorter latency and higher penetrance. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
10 Samples
Download data: TXT
Series
Accession:
GSE35560
ID:
200035560
4.

SNP data from Neuroblastoma samples

(Submitter supplied) Neuroblastoma in advanced stages is among the most intractable pediatric cancers, even with the recent therapeutic advances. Neruroblastoma harbours a variety of genetic changes, including a high frequency of MYCN amplification, loss of heterozygosity in 1p36 and 11q, and gain of genetic material from 17q, all of which have been implicated in the pathogenesis of neuroblastoma. However, the scarcity of reliable molecular targets has hampered the development of effective therapeutic agents targeting neuroblastoma. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platforms:
GPL2005 GPL3718 GPL2004
262 Samples
Download data: CEL, CHP
Series
Accession:
GSE12494
ID:
200012494
5.

Expression data from neuroblastoma of TH-MYCN/KI Alk mice

(Submitter supplied) Neuroblastoma is an embryonal neoplasm that remains of dramatic prognosis in its aggressive forms. Activating mutations of the ALK tyrosine kinase receptor have been identified in sporadic and familial cases of this cancer. We generated knock-in mice carrying the two most frequent Alk mutations observed in neuroblastoma patients. We used microarrays to detail the global programme of gene expression underlying the impact of ALK mutations on neuroblastoma formation in a MYCN amplified background.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16225
31 Samples
Download data: CEL
Series
Accession:
GSE46583
ID:
200046583
6.

Expression profiling of the murine neural crest precursor cell line, JoMa1

(Submitter supplied) JoMa1 cells are pluripotent precursor cells, derived from the neural crest of mice transgenic for tamoxifen-inducible c-Myc. Following transfection with a cDNA encoding for MYCN, cells become immortlized even in the absence of tamoxifen.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE27159
ID:
200027159
7.

SNP array analysis of neuroblastic tumor NB99

(Submitter supplied) The genetic aberrations of NB tumor NB99 were determined using the Affymetrix SNP chip 50K array (Hind III).
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platform:
GPL2004
1 Sample
Download data: CEL
Series
Accession:
GSE12461
ID:
200012461
8.

Expression profiling of neuroblastic tumors

(Submitter supplied) The expression profiles of 64 neuroblastic tumors (mainly neuroblastoma) were determined on Affymetrix chips HG U133 Plus 2.0.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
64 Samples
Download data: CEL
Series
Accession:
GSE12460
ID:
200012460
9.

SNP array analysis of neuroblastoma tumors

(Submitter supplied) Chromosome 1p LOH was seen in one-third of cases. LOH events on chromosomes 11q and 1p were generally accompanied by copy number loss. The one exception was on chromosome 11p, where LOH in all 4 cases was accompanied by normal copy number or diploidy, implying uniparental disomy. Amplification of MYCN was also noted, and also, amplification of a second gene, ALK, in a single case. Keywords: SNP array analysis
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platforms:
GPL1266 GPL2641
44 Samples
Download data: CEL, TXT
Series
Accession:
GSE8333
ID:
200008333
10.

Anaplastic lymphoma kinase (ALK) inhibitor response in neuroblastoma is highly correlated with ALK mutation status, ALK mRNA and protein levels.

(Submitter supplied) High anaplastic lymphoma kinase (ALK) protein levels may be correlated with an unfavorable prognosis in neuroblastoma (NBL) patients, regardless of ALK mutation status. We therefore examined the correlation between levels of ALK, phosphorylated ALK (pALK) and downstream signaling proteins and response to ALK inhibition in a large panel of both ALK mutated (MUT) and wild type (WT) NBL cell lines. Six of the nineteen NBL cell lines had a point mutation and four an amplification of the ALK gene. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
17 Samples
Download data: CEL, CHP
Series
Accession:
GSE22771
ID:
200022771
11.

Expression data from neuroblastoma of TH-MYCN/KI RetM919T mice

(Submitter supplied) The RET gene has been identified previously as a target of activated ALK at the mRNA level in both human neuroblastoma cell lines and primary tumors as well as in murine tumors driven by mutated Alk and MYCN. Moreover, it has been shown that tumor growth of murine TH-MYCN/KI Alkmut tumors was impaired upon Ret inhibition by the vandetanib inhibitor, suggesting RET as a therapeutic target in ALK mutated neuroblastoma. more...
Organism:
Mus musculus
Type:
Expression profiling by array; Third-party reanalysis
Platform:
GPL16368
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE72678
ID:
200072678
12.

Differentially expressed genes in certinib-resistant NB-1 xenografts

(Submitter supplied) The goal of this study is to elucidate the molecular mechanism that allowed NB-1 xenograft tumors to grow out in the presence of continued ALK inhibition. Poly(A)-selected RNA was extracted from tissues of NB-1 tumors that progressed on ceritinib treatment and those treated with a vehicle to identify differentially expressed genes between these two groups.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
4 Samples
Download data: TXT
Series
Accession:
GSE82143
ID:
200082143
13.

Alteration of treatment of the ALK inhibitor in ALK-amplified neuroblastoma

(Submitter supplied) Anaplastic Lymphoma Kinase (ALK) most frequently mutated in neuroblastoma (NB) and is atractive molecular target for therapy. However, efficacy of the ALK inhibitor against ALK-amplified NB is unclear. To elucidate genetic alterations induced by treatment of the ALK inhibitor, we compared expression profile between ALK inhibitor-treated and DMSO-treated NB39nu cells using Agilent SurePrint G3 Human GE 8x60K V2 Microarray Kit
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
12 Samples
Download data: TXT
Series
Accession:
GSE107354
ID:
200107354
14.

Tumor-derived Schwann-like cells promote neuroblastoma survival through secreted trophic factors

(Submitter supplied) Neuroblastoma (NB) is comprised of a mixture of neuroblastic N-type cancer cells, and Schwannian stromal S-type cells. Sublines of N- and S-type cells were isolated from an early passage of SK-N-SH NB cell line. RNA-Seq analysis was conducted on slected N- and S-type cells in order to define their unique expression profiles.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23227
4 Samples
Download data: TXT
Series
Accession:
GSE139235
ID:
200139235
15.

Global gene expression analysis in NGP CRISPR control cells and NGP ALK(LF655del) cells.

(Submitter supplied) We performed gene expression profiling by Affymetrix primeview array in both NGP CRISPR control cells and NGP ALK(LF655del) cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16043
6 Samples
Download data: CEL
Series
Accession:
GSE140025
ID:
200140025
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