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Links from GEO DataSets

Items: 20

1.
Full record GDS4625

Dorsal root ganglion in three peripheral neuropathic pain models: time course

Analysis of L4 and L5 dorsal root ganglion (DRGs) up to 40 days post-injury in three distinct peripheral neuropathic pain models: spared nerve injury (SNI), chronic constriction injury (CCI), and spinal nerve ligation injury (SNL). Results provide insight into putative pain modulating genes.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 6 protocol, 5 time sets
Platform:
GPL85
Series:
GSE30691
56 Samples
Download data: CEL
2.

Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1

(Submitter supplied) Not all patients with nerve injury develop neuropathic pain. The extent of nerve damage and age at the time of injury are two of the few risk factors identified to date. In addition, preclinical studies show that neuropathic pain variance is heritable. To define such factors further, we performed a large-scale gene profiling experiment which plotted global expression changes in the rat dorsal root ganglion in three peripheral neuropathic pain models. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS4625
Platform:
GPL85
56 Samples
Download data: CEL
Series
Accession:
GSE30691
ID:
200030691
3.

MicroRNA profiling in dorsal root ganglion after sciatic nerve injury

(Submitter supplied) Changes in microRNA (miRNA) expression in the mouse L4 and L5 dorsal root ganglion following unilateral sciatic nerve transection. The timepoint of 7 days post-axotomy was chosen to capture miRNA expression profiles at a time when the injured neurons were beginning to regenerate.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL13498
3 Samples
Download data: TXT
Series
Accession:
GSE29096
ID:
200029096
4.

Analysis of gene expression during neurite outgrowth and regeneration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL81 GPL339 GPL82
74 Samples
Download data: CEL
Series
Accession:
GSE9744
ID:
200009744
5.

Analysis of gene expression during neurite outgrowth and regeneration (MG-U74B)

(Submitter supplied) We have undertaken a genome-wide study of transcriptional activity in embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time course of neurite outgrowth in vitro. Gene expression observed in these models likely includes both developmental gene expression patterns and regenerative responses to axotomy, which occurs as the result of tissue dissection. Comparison across both models revealed many genes with similar gene expression patterns during neurite outgrowth. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL82
26 Samples
Download data: CEL
Series
Accession:
GSE9740
ID:
200009740
6.

Analysis of gene expression during neurite outgrowth and regeneration (MG-U74A)

(Submitter supplied) We have undertaken a genome-wide study of transcriptional activity in embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time course of neurite outgrowth in vitro. Gene expression observed in these models likely includes both developmental gene expression patterns and regenerative responses to axotomy, which occurs as the result of tissue dissection. Comparison across both models revealed many genes with similar gene expression patterns during neurite outgrowth. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
26 Samples
Download data: CEL
Series
Accession:
GSE9739
ID:
200009739
7.

Analysis of gene expression during neurite outgrowth and regeneration (430A and 430A 2.0 array)

(Submitter supplied) We have undertaken a genome-wide study of transcriptional activity in embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time course of neurite outgrowth in vitro. Gene expression observed in these models likely includes both developmental gene expression patterns and regenerative responses to axotomy, which occurs as the result of tissue dissection. Comparison across both models revealed many genes with similar gene expression patterns during neurite outgrowth. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
22 Samples
Download data: CEL
Series
Accession:
GSE9738
ID:
200009738
8.

PROM1(CD133)-dependent expressed genes from mouse embryonic DRG neurons

(Submitter supplied) Prom1, also knwon as CD133 is a stem cell marker that are down-regulated during developmental process. Here we first reports that PROM1 is a regulator of expression of specific sets of genes from DRG neurons.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: XLSX
Series
Accession:
GSE147936
ID:
200147936
9.

Gene expression in mouse DRG neurons at 2 or 5 days post-sciatic lesion in WT and Nfil3-KO

(Submitter supplied) Mice with a deletion of transcription factor Nfil3 show delayed functional regeneration after sciatic lesion compared to WT mice. To analyze differential gene expression, sciatic nerves were lesioned and nerve endings were coaptated. After two or 5 days, DRGs L4 and L5 were dissected out and gene expression was measured by microarray. Control tissue was taken from the non-injured side. We found that expression of classic regeneration associated genes was similar in WT and Nfil3 KO mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
24 Samples
Download data: TXT
Series
Accession:
GSE66259
ID:
200066259
10.

Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

(Submitter supplied) N6-methyladenosine (m6A) affects multiple aspects of mRNA metabolism and regulates developmental transitions by promoting mRNA decay. Little is known about the role of m6A in the adult mammalian nervous system. Here we report that sciatic nerve lesion elevates levels of m6A-tagged transcripts encoding many regeneration-associated genes and protein translation machinery components in the adult mouse dorsal root ganglion (DRG). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL19057
24 Samples
Download data: BED, BEDGRAPH, TXT
11.

Regulation of neuroregeneration by long noncoding RNAs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
75 Samples
Download data: BW, TXT
Series
Accession:
GSE119491
ID:
200119491
12.

Regulation of neuroregeneration by long noncoding RNAs [ATAC-seq]

(Submitter supplied) In mammals, neurons in the peripheral nervous system (PNS) have regenerative capacity following injury, a capacity which but it is generally absent in the central nervous system (CNS). This difference is attributed, at least in part, to the intrinsic ability of PNS neurons to activate a unique regenerative transcriptional program following injury. Long noncoding RNA (lncRNA) transcripts are typically expressed in a small subset of cell types and may facilitate specificity in regulatory programs. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
12 Samples
Download data: BED
Series
Accession:
GSE119489
ID:
200119489
13.

Regulation of neuroregeneration by long noncoding RNAs [RNA-seq]

(Submitter supplied) In mammals, neurons in the peripheral nervous system (PNS) have regenerative capacity following injury, a capacity which but it is generally absent in the central nervous system (CNS). This difference is attributed, at least in part, to the intrinsic ability of PNS neurons to activate a unique regenerative transcriptional program following injury. Long noncoding RNA (lncRNA) transcripts are typically expressed in a small subset of cell types and may facilitate specificity in regulatory programs. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
63 Samples
Download data: BW, GTF, TXT
Series
Accession:
GSE111497
ID:
200111497
14.

Jun promotes axon regeneration by binding enhancer sites and dimerizing with Atf3

(Submitter supplied) Axon regeneration is a necessary step toward functional recovery after spinal cord injury. The AP-1 transcription factor c-Jun has long been known to play an important role in directing the transcriptional response of Dorsal Root Ganglion (DRG) neurons to peripheral axotomy that results in successful axon regeneration. Here we performed ChIPseq for Jun in mouse DRG neurons after a sciatic nerve crush or sham surgery in order to measure the changes in Jun’s DNA binding in response to peripheral axotomy. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
12 Samples
Download data: BED
Series
Accession:
GSE105442
ID:
200105442
15.

Enhanced neuronal regeneration in the CAST/Ei mouse strain is linked to expression of differentiation markers after injury

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL18635 GPL19057
530 Samples
Download data: CSV
Series
Accession:
GSE98417
ID:
200098417
16.

miRNA sequencing of primary mouse dorsal root ganglia

(Submitter supplied) Peripheral nerve regeneration after injury is a complex process involving a large number of transcriptional changes. How these changes impact the regenerative outcome is though, poorly understood. Here, we take advantage of the genetically based differences in the peripheral and central regenerative capacity of CAST/Ei and C57BL/6j inbred mice to better understand the molecular bases driving superior regeneration in the CAST/Ei mouse strain.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL18635
14 Samples
Download data: CSV
Series
Accession:
GSE98416
ID:
200098416
17.

Single cell sequencing of primary dorsal root ganglia from CAST/Ei or C57BL/6 mouse highlights strain differences in cellular populations.

(Submitter supplied) Peripheral nerve regeneration after injury is a complex process involving a large number of transcriptional changes. How these changes impact the regenerative outcome is though, poorly understood. Here, we take advantage of the genetically based differences in the peripheral and central regenerative capacity of CAST/Ei and C57BL/6j inbred mice to better understand the molecular bases driving superior regeneration in the CAST/Ei mouse strain. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
516 Samples
Download data: CSV
Series
Accession:
GSE98415
ID:
200098415
18.

Postnatal developmental changes in Sprague-Dawley rats in the model of neuropathic pain 'spare nerve injury'

(Submitter supplied) Neuropathic pain is an apparently spontaneous experience triggered by abnormal physiology of the peripheral or central nervous system, which evolves with time. Neuropathic pain arising from peripheral nerve injury is characterized by a combination of spontaneous pain, hyperalgesia and allodynia. There is no evidence of this type of pain in human infants or rat pups; brachial plexus avulsion, which causes intense neuropathic pain in adults, is not painful when the injury is sustained at birth. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
16 Samples
Download data: CEL
Series
Accession:
GSE15041
ID:
200015041
19.

Whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat, at different sequencing depths

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL6543 GPL6194 GPL10669
30 Samples
Download data: CEL
Series
Accession:
GSE53861
ID:
200053861
20.

Whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat, at different sequencing depths (Affymetrix exon-level)

(Submitter supplied) RNA derived from the L5 DRG 7 days following L5-SNT and from naïve L5-DRG tissue was subjected to microarray analysis and expression was determined at the exon and gene level
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6194
6 Samples
Download data: CEL
Series
Accession:
GSE53860
ID:
200053860
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