Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 20

1.
Full record GDS4757

Corticosterone effect on hippocampus: dose response

Analysis of hippocampal CA1 from adrenalectomized F344 males maintained for 3 months with implanted corticosterone (CORT) pellets to produce low or intermediate (glucocorticoid receptor-activating) blood levels of CORT. Results provide insight into the effects of chronic CORT on the hippocampus.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 4 agent, 4 dose, 2 protocol sets
Platform:
GPL85
Series:
GSE37618
39 Samples
Download data: CEL
2.

Glucocorticoid-Dependent Hippocampal Transcriptome in Male Rats: Pathway-Specific Alterations with Aging

(Submitter supplied) Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover, evidence is inconsistent regarding the longstanding hypothesis that chronic GC exposure promotes brain aging/Alzheimer's disease. Here, we adrenalectomized male F344 rats at 15-months-of-age, maintained them for 3 months with implanted corticosterone (CORT) pellets producing low or intermediate (glucocorticoid-receptor (GR)-activating) blood levels of CORT, and performed microarray/pathway analyses in hippocampal CA1. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS4757
Platform:
GPL85
39 Samples
Download data: CEL
Series
Accession:
GSE37618
ID:
200037618
3.

Genome-wide analysis of T3 and CORT dependent gene expression and hormone synergy in mouse hippocampal neurons (HT-22)

(Submitter supplied) Analysis of T3 and CORT dependent gene expression tested in the mouse hippocampal neuronal cell line HT-22. The experiment was done to identify genes which are differentially regulated by the two hormones as well as to identify genes which are synergistically regulated by combined T3 + CORT treatment. Results provide an exploratory dataset for studying T3 and CORT regulation in mouse hippocampal neurons.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
12 Samples
Download data: TXT
Series
Accession:
GSE132423
ID:
200132423
4.

The Influence of Sleep Deprivation on Hippocampal CA1 Gene Expression: Relation to Stress and Aging

(Submitter supplied) Sleep deprivation (SD) in young adults is associated with metabolic, stress and cognitive responses that are also characteristic of brain aging. Given that sleep architecture changes with age, including increased fragmentation and decreased slow wave activity, it seems reasonable to investigate potential molecular relationships between SD and aging in brain tissue. Here, we tested the hypothesis that young rats exposed to 24 or 72 hour SD would respond with stress and aging-like shifts in brain hippocampal CA1 gene expression. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL85
69 Samples
Download data: CEL
Series
Accession:
GSE34424
ID:
200034424
5.

Corticosterone regulation of mRNAs and and corresponding RU486 antagonism in astrocytes in vitro

(Submitter supplied) Analysis of mRNA gene expression changes mediated by natural glucocorticoid ligand corticosterone in mouse cortical primary astrocyte cultures; also, parallel analysis of RU486 (mifepristone) antagonism of corticosterone-mediated mRNA changes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
36 Samples
Download data: TXT
Series
Accession:
GSE39270
ID:
200039270
6.

Two Populations of Glucocorticoid Receptor-Binding Sites in the Male Rat Hippocampal Genome

(Submitter supplied) In the present study, genomic binding sites of glucocorticoid receptors (GR) were identified in vivo in the rat hippocampus applying chromatin immunoprecipitation followed by next-generation sequencing. We identified 2470 significant GR-binding sites (GBS) and were able to confirm GR binding to a random selection of these GBS covering a wide range of P values. Analysis of the genomic distribution of the significant GBS revealed a high prevalence of intragenic GBS. more...
Organism:
Rattus norvegicus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11282
4 Samples
Download data: BED, WIG
Series
Accession:
GSE84202
ID:
200084202
7.

Transcriptomic response of the arcuate nucleus to oral corticosterone treatment

(Submitter supplied) Glucocorticoids (GCs) are widely prescribed to treat inflammatory and autoimmune conditions. However, patients often develop adverse metabolic effects, including hyperphagia, obesity, and hyperglycemia.The arcuate nucleus has an established role in the central control of energy balance. In this study we examined the transcriptomic response of the arcuate nucleus to oral corticosterone treatment. Gene expression changes were measured after 2 days and 4 weeks of Cort treatment in ad libitum fed C57BL6/J mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL21103
20 Samples
Download data: TXT
Series
Accession:
GSE128148
ID:
200128148
8.

Regional commonalities and specificities of age-related changes in hippocampal transcriptome.

(Submitter supplied) The project examined age-related change in hippocampal gene expression in Fisher 344 x Brown Norway F1 rats from the NIA aging colony (Adult = 12M, Aged = 24M). CA1, CA3, and DG specific dissections were examined from one cohort of animals and from a second cohort whole hippocampus was used.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
60 Samples
Download data: TXT
Series
Accession:
GSE55352
ID:
200055352
9.

FFK506-Binding Protein 12.6/1b, a negative regulator of [Ca2+], rescues memory and restores genomic regulation in the hippocampus of aging rats

(Submitter supplied) Hippocampal overexpression of FK506-binding protein 12.6/1b (FKBP1b), a negative regulator of ryanodine receptor Ca2+ release, reverses aging-induced memory impairment and neuronal Ca2+ dysregulation. Here, we test the hypothesis that FKBP1b also can protect downstream transcriptional networks from aging-induced dysregulation. We gave hippocampal microinjections of FKBP1b-expressing viral vector to male rats at either 13-months-of-age (long-term) or 19-months-of-age (short-term) and tested memory performance in the Morris water maze at 21-months-of-age. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
23 Samples
Download data: CEL
Series
Accession:
GSE102054
ID:
200102054
10.

Gene Microarrays in Hippocampal Aging

(Submitter supplied) Male Fischer 344 rats aged 4 months (young, n=10), 14 months (mid-aged, n=10), and 24 months (aged, n=10) were trained sequentially on two tasks: Morris Spatial Water Maze (SWM) and Object Memory Task (OMT). The training/testing sequence lasted 7 d, and hippocampal tissue was collected 24 hr later. Training and testing occured on each day except for days 2 and 3 of the 7 d sequence. (01/10/05: Series was updated to correct mislabeling of all sample signal values within the Young Treatment Group) Keywords = bioinformatics Keywords = gene expression Keywords = memory Keywords = synaptic plasticity Keywords = myelin Keywords = inflamation Keywords = aging Keywords: repeat sample
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS520
Platform:
GPL85
29 Samples
Download data: CEL, TXT
Series
Accession:
GSE854
ID:
200000854
11.
Full record GDS520

Hippocampal aging and cognitive impairment

Identification of aging-dependent cognitive decline gene expression. Hippocampal CA1 tissue collected from 4, 14, and 24 month old male Fischer 344 rats after 7 days training on water maze and object memory task.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 age sets
Platform:
GPL85
Series:
GSE854
29 Samples
Download data: CEL, TXT
12.

Genetic, functional and molecular features of glucocorticoid receptor binding

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL6947 GPL9115
104 Samples
Download data
Series
Accession:
GSE45640
ID:
200045640
13.

Genetic, functional and molecular features of glucocorticoid receptor binding (sequencing)

(Submitter supplied) Glucocorticoids (GCs) are key mediators of stress response and are widely used as pharmacological agents to treat immune diseases, such as asthma and inflammatory bowel disease, and certain types of cancer. GCs act mainly by activating the GC receptor (GR), which interacts with other transcription factors to regulate gene expression. Here, we combined different functional genomics approaches to gain molecular insights into the mechanisms of action of GC. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9115
8 Samples
Download data: TXT
Series
Accession:
GSE45638
ID:
200045638
14.

Genetic, functional and molecular features of glucocorticoid receptor binding (expression)

(Submitter supplied) Glucocorticoids (GCs) are key mediators of stress response and are widely used as pharmacological agents to treat immune diseases, such as asthma and inflammatory bowel disease, and certain types of cancer. GCs act mainly by activating the GC receptor (GR), which interacts with other transcription factors to regulate gene expression. Here, we combined different functional genomics approaches to gain molecular insights into the mechanisms of action of GC. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
96 Samples
Download data: TXT
Series
Accession:
GSE44248
ID:
200044248
15.

Expression data from aged, calorically restricted rat hippocampal regions CA1, CA3, and DG

(Submitter supplied) Aging is associated with a decline in hippocampal mediated learning and memory, a process wich can be ameliorated by dietary (caloric) restriction. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction. Old rats were determined to be good performers (GP) or poor performers (PP) in behavioral tests to assess thier hippocampal function.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
45 Samples
Download data: CEL, CHP, TXT, XLS
Series
Accession:
GSE21681
ID:
200021681
16.

Divergent transcriptional activation by glucocorticoids in mouse and human macrophages is the result of gain and loss of enhancers

(Submitter supplied) Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid receptor (GR) was detected at candidate enhancers in the vicinity of induced genes in both species and this was strongly associated with canonical GR binding motifs. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
4 related Platforms
52 Samples
Download data: CEL
Series
Accession:
GSE61881
ID:
200061881
17.

Expression response of human monocyte derived macrophages to dexamethasone over a 24h time series

(Submitter supplied) Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid receptor (GR) was detected at candidate enhancers in the vicinity of induced genes in both species and this was strongly associated with canonical GR binding motifs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13158
24 Samples
Download data: CEL
Series
Accession:
GSE61880
ID:
200061880
18.

Expression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages

(Submitter supplied) Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid receptor (GR) was detected at candidate enhancers in the vicinity of induced genes in both species and this was strongly associated with canonical GR binding motifs. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11180
18 Samples
Download data: CEL
Series
Accession:
GSE61879
ID:
200061879
19.

Genome wide binding of glucocorticoid receptor in dexamethasone treated human monocyte derived macrophages

(Submitter supplied) Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid receptor (GR) was detected at candidate enhancers in the vicinity of induced genes in both species and this was strongly associated with canonical GR binding motifs. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL16791
2 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE61878
ID:
200061878
20.

Genome wide binding of glucocorticoid receptor in dexamethasone treated mouse bone marrow derived macrophages

(Submitter supplied) Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid receptor (GR) was detected at candidate enhancers in the vicinity of induced genes in both species and this was strongly associated with canonical GR binding motifs. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
8 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE61877
ID:
200061877
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=4|blobid=MCID_616ba39145cdce078945f894|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center