GEO DataSets

Analysis of heart from high-fat diet-induced obese (DIO) C57BL/6 males exposed to mainstream (MS) or sidestream (SS) cigarette smoke. Smoking and obesity are risk factors for heart disease. Results provide insight into molecular mechanisms underlying cardiac responses of smoke-exposed DIO animals.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 disease state, 3 protocol sets

Platform:

GPL8321

Series:

GSE47022

45 Samples

Download data: CEL

(Submitter supplied) To identify biosignatures that describe these lifestyle susceptibility factors, we performed parallel exposures of regular weight (RW) C57BL/6 and diet-induced obese (DIO) C57BL/6 mice to cigarette smoke, either mainstream (MS) or sidestream (SS), mimicking both the smoker and environmental exposure through second-hand smoke, respectively. Transcriptional responses were measured by global microarray analysis of heart tissue.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4799

Platform:

GPL8321

45 Samples

Download data: CEL

(Submitter supplied) To identify biosignatures that describe these lifestyle susceptibility factors, we performed parallel exposures of regular weight (RW) C57BL/6 and diet-induced obese (DIO) C57BL/6 mice to cigarette smoke, either mainstream (MS) or sidestream (SS), mimicking both the smoker and environmental exposure through second-hand smoke, respectively. Transcriptional responses were measured by global microarray analysis of lung tissue.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

48 Samples

Download data: CEL

(Submitter supplied) Gene expression data on wild-type and Rora mutant mice exposed to room air and smoke. The results provide a general insight into the relationship of Rora to known DNA damage response pathways and its role in cigarette smoke-induced airspace enlargement.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

12 Samples

Download data: TXT

(Submitter supplied) These studies tested the hypotheses that smoke induces changes in mRNA profiles that are dependent on sex and the health status of the lung, and that the effects of smoke are different after 1 day compared to 5 days of smoke exposure. The ways in which the lungs modulate their response to cigarette smoke after repeated exposures are important for understanding the toxicology of smoke, for developing biomarkers of chronic smoke exposure, and for understanding the therapeutic potential in regulatory signaling pathways that are beneficial or detrimental to lung health. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL22070

79 Samples

Download data: CEL

(Submitter supplied) We have investigated the effects of cigarette smoke exposure in three different strains of mice. DBA/2 and C57Bl/6J are susceptible to smoke and develop different lung changes in response to chronic exposure, while ICR mice are resistant to smoke and do not develop emphysema. The present study was carried out to determine early changes in the gene expression profile of mice exposed to cigarette smoke with either a susceptible or resistant phenotype. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

6 Samples

Download data: CEL, CHP

(Submitter supplied) To identify key biological pathways that define susceptibility factors for pulmonary infection during obesity, diet-induced obese (DIO) and regular weight (RW) C57BL/6 mice were exposed to 0.5 µg/L inhaled lipopolysaccharide (LPS) for 1 hr/d for 4 days over a period of 2 weeks. Transcriptional responses were measured by global microarray analysis of lung tissue.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

32 Samples

Download data: CEL

(Submitter supplied) The aim of this study was to characterize the obesity-related gene expression profiles between bone marrow adipocytes and peripheral white adipocytes from obese mice fed with high fat diet and leptin deficient mice Alterations of gene expression with high fat diet and in mice lacking leptin were analyzed in bone marrow and peripheral white adipocytes isolated from C57BL/6J male mice using Affymetrix Mouse Gene 1.0 ST arrays.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

36 Samples

Download data: CEL, TXT

(Submitter supplied) Cigarette smoke (CS) imposes a strong oxidative burden on exposed tissues resulting in a severely disturbed oxidant/antioxidant balance, which in the context of chronic exposure is assumed to be a key contributor to CS-related diseases. Because of its emerging central role in orchestrating the general cellular antioxidant response, the pathway leading to the activation of the transcription factor Nrf2 has received mounting attention over the past decade in investigations aimed at elucidating CS-induced patho-physiological mechanisms. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3622

Platform:

GPL1261

110 Samples

Download data: CEL

Analysis of lungs from transcription factor Nrf2-deficient animals exposed to cigarette smoke (CS) at various doses and for various lengths of time with or without a subsequent recovery period. Results provide insight into the impact of Nrf2 in acute and subchronic smoking scenarios.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 4 dose, 2 genotype/variation, 3 protocol, 3 time sets

Platform:

GPL1261

Series:

GSE18344

110 Samples

Download data: CEL

(Submitter supplied) Second-hand smoke (SHS) exposure during pregnancy has adverse effects on offspring. We used microarrays to characterize the gene expression changes caused by in-utero exposure and adult exposure to SHS in adult mouse lungs.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4609

Platform:

GPL1261

16 Samples

Download data: CEL

Analysis of lung from 15-wk-old males exposed in utero and then as adults to second hand smoke (SHS). These animals exhibit increased airway hyperresponsiveness. Results provide insight into the role of in utero SHS exposure in potentiating subsequent adult physiological responses to SHS exposure.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 4 protocol sets

Platform:

GPL1261

Series:

GSE36810

16 Samples

Download data: CEL

(Submitter supplied) Time-course analysis of adipocyte gene expression profiles response to high fat diet. The hypothesis tested in the present study was that in diet-induced obesity, early activation of TLR-mediated inflammatory signaling cascades by CD antigen genes, leads to increased expression of pro-inflammatory cytokines and chemokines, resulting in chronic low-grade inflammation. Early changes in collagen genes may trigger the accumulation of ECM components, promoting fibrosis in the later stages of diet-induced obesity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS6247 GDS6248

Platform:

GPL6887

91 Samples

Download data: TXT

Analysis of livers of C57BL/6J mice fed a high fat diet for up to 24 weeks. Significant body weight gain was observed after 4 weeks. Results provide insight into the effect of high fat diets on metabolism in the liver.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 protocol, 9 time sets

Platform:

GPL6887

Series:

GSE39549

51 Samples

Download data

Analysis of epididymal and mesenteric white adipose tissues (WAT) of mice fed a high fat diet for up to 24 weeks. Excessive fat accumulation was evident in visceral WAT depots after 4 weeks. Results provide insight into the molecular events that occur during the development of diet-induced obesity.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol, 5 time, 2 tissue sets

Platform:

GPL6887

Series:

GSE39549

40 Samples

Download data

(Submitter supplied) RNA sequencing was used to identify genes up- and down-regulated when Fa was grown in cigarette smoke media

Organism:

Filifactor alocis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32579

9 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10379

1349 Samples

Download data: CEL

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10379

445 Samples

Download data: CEL

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10379

405 Samples

Download data: CEL

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10379

499 Samples

Download data: CEL