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Links from GEO DataSets

Items: 6

1.
Full record GDS4822

Lung response to thoracic irradiation: dose response and time course

Analysis of total lung from C57Bl/Ncr females exposed to 0, 5, or 17.5 Gy at 2, 4, 8, 16, and 30 weeks after thoracic irradiation. The lungs show extensive fibrosis at 30 weeks after 17.5 Gy. Results provide insight into molecular mechanisms underlying radiation-induced pulmonary fibrosis (RIPF).
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 dose, 5 time sets
Platform:
GPL1261
Series:
GSE41789
45 Samples
Download data: CEL
2.

Senescence gene signature of radiation fibrosis

(Submitter supplied) Radiation lung injury is characterized by early inflammation and late fibrosis. The causes underlying the chronic, progressive nature of radiation injury are poorly understood. Here, we report that the gene expression of irradiated lung tissue correlates with that observed in the lungs in aged animals. We demonstrate that NOX4 expression and superoxide elaboration is increased in irradiated lungs and pneumocytes in a dose dependent fashion. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4822
Platform:
GPL1261
45 Samples
Download data: CEL
Series
Accession:
GSE41789
ID:
200041789
3.

Exposure of radiation on mouse lung

(Submitter supplied) This study was designed to identify molecular changes induced by radiation in mouse lung.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
9 Samples
Download data: TXT
Series
Accession:
GSE60541
ID:
200060541
4.

Targeting p16-induced Senescence Prevents Cigarette Smoke-Induced Emphysema by Promoting IGF1/Akt1 Signaling in mice

(Submitter supplied) Increased IGF1 signaling in p16 -/- lungs
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL26852
4 Samples
Download data: XLSX
Series
Accession:
GSE133380
ID:
200133380
5.

Single cell RNAseq analysis of mouse lung after irradiation

(Submitter supplied) Thoracic radiation therapy is limited by the development of acute (i.e. pneumonitis) and late (i.e. pulmonary fibrosis) side-effects. The goal of this study is to analyze, at the single cell level, the molecular impact of two radiation treatments : a conventional/clinical (CONV) modality vs. FLASH, a new radiation method that spares healthy tissue from late radiation-induced toxicities (Science Translational Medicine 6: 245ra293, 2014). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
3 Samples
Download data: MTX, TSV
Series
Accession:
GSE133992
ID:
200133992
6.

Regulation and role of the pro-apoptotic transcription factor CHOP in Idiopathic Pulmonary Fibrosis

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal interstitial lung disease characterized by alveolar epithelial cell type II (AECII) injury and enhanced fibroblast/myofibroblast proliferation. Recent data show that maladaptive endoplasmic reticulum (ER)-stress leading to AECII apoptosis could play a key role in IPF, although it is still unclear how precisely such response is initiated and signalled. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
102 Samples
Download data
Series
Accession:
GSE87298
ID:
200087298
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