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Links from GEO DataSets

Items: 20

1.
Full record GDS4832

Bronchial epithelial cell response to rhinovirus infection and cigarette smoke exposure

Analysis of cultured bronchial epithelial cells (BECs) after rhinovirus (RV) infection, cigarette smoke extract exposure, or both. The airway epithelial cell is the primary site of RV infection. Results provide insight into the impact of cigarette smoking on the response of BECs to RV infections.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 agent, 4 individual sets
Platform:
GPL570
Series:
GSE27973
16 Samples
Download data: CEL, CHP
2.

Human airway epithelial responses to rhinovirus infection and cigarette smoke extract alone and in combination

(Submitter supplied) This study was performed to test the hypothesis that cigarette smoke extract would alter the responses of primary cultures of human bronchial epithelial cells to infection with purified human rhinovirus 16. The data show marked alterations in rhinovirus-induced expression profiles of a number of genes in the presence of cigarette smoke extract (CSE).
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4832
Platform:
GPL570
16 Samples
Download data: CEL, CHP
Series
Accession:
GSE27973
ID:
200027973
3.

Growth differentiation factor 15 (GDF15) promotes human rhinovirus infection and inflammation

(Submitter supplied) Analysis of normal human tracheobronchial epithelial cells treated with or without recombinant human GDF15 for two hours. Results provide insights of the genome-wide transcriptional regulation by Smad1 associated with GDF15 in human airway epithelium.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17303
4 Samples
Download data: BED
Series
Accession:
GSE100625
ID:
200100625
4.

Phenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus

(Submitter supplied) We report the application of RNA sequencing technology for high-throughput profiling of gene expression responses to human rhinovirus infection at 24 hours in air-liquid interface human airway epithelial cell cultures derived from 6 asthmatic and 6 non-asthmatic donors. RNA-seq analysis identified sets of genes associated with asthma specific viral responses. These genes are related to inflammatory pathways, epithelial remodeling and cilium assembly and function, including those described previously (e.g. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
24 Samples
Download data: TXT
Series
Accession:
GSE61141
ID:
200061141
5.

Human rhinovirus infection causes different DNA methylation changes in nasal epithelial cells from healthy and asthmatic subjects

(Submitter supplied) Background: Mechanisms underlying the development of virus-induced asthma exacerbations remain unclear. Objective: To investigate if epigenetic mechanisms could be involved in virus-induced asthma exacerbations, we undertook DNA methylation profiling in asthmatic and healthy nasal epithelial cells (NECs) during Human Rhinovirus (HRV) infection in vitro. Methods: Global and loci-specific methylation profiles were determined via Alu element and Infinium Human Methylation 450K microarray respectively. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
18 Samples
Download data: TXT
Series
Accession:
GSE52074
ID:
200052074
6.

Role of IRF7 in airway epithelial cell responses to human rhinovirus infection.

(Submitter supplied) Primary human bronchial epithelial cells were transfected with siRNA to knockdown IRF7 gene expression, allowed to recover, and then infected with human rhinovirus. At 24 hrs post rhinovirus infection, gene expression patterns were profiled on microarrays.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL20609
20 Samples
Download data: CEL
Series
Accession:
GSE70190
ID:
200070190
7.

Gene expression profiles during in vivo human rhinovirus infection: insights into the host response.

(Submitter supplied) RATIONALE: Human rhinovirus infections cause colds and trigger exacerbations of lower airway diseases. OBJECTIVES: To define changes in gene expression profiles during in vivo rhinovirus infections. METHODS: Nasal epithelial scrapings were obtained before and during experimental rhinovirus infection, and gene expression was evaluated by microarray. Naturally acquired rhinovirus infections, cultured human epithelial cells, and short interfering RNA knockdown were used to further evaluate the role of viperin in rhinovirus infections. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
93 Samples
Download data: CEL, CHP
Series
Accession:
GSE11348
ID:
200011348
8.

A Systems Approach to Understanding Human Rhinovirus and Influenza Virus Infection

(Submitter supplied) Human rhinovirus and influenza virus infections of the upper airway lead to colds and the flu and can trigger exacerbations of lower airway diseases including asthma and chronic obstructive pulmonary disease. Despite modest advances in the diagnosis and treatment of infections by these viruses, novel diagnostic and therapeutic targets are still needed to differentiate between the cold and the flu, since the clinical course of influenza can be severe while that of rhinovirus is usually more mild. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
186 Samples
Download data: CEL
Series
Accession:
GSE71766
ID:
200071766
9.

Regional heterogeneity in response of airway epithelial cells to cigarette smoke

(Submitter supplied) To investigate the biochemical and genetic alterations that occur in response to cigarette smoke exposure among airway epithelial cells from different sites in the lungs, we performed microarray-based analysis using small airway epithelial cells (SAEC) and normal human bronchial epithelial cells (NHBE) following 24 h of cigarette smoke extract (CSE). In microarray-based analysis, the small airway showed higher susceptibility to CS compared to the large airway, such as enhanced expression of inflammatory-related pathways including the TNF signaling pathway. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
8 Samples
Download data: TXT
Series
Accession:
GSE107200
ID:
200107200
10.

RNA-sequencing of bronchial epithelial cells from an adult cohort including asthmatics, COPD and healthy controls, cultured with Rhinovirus 1A

(Submitter supplied) Rhinovirus infections exacerbate chronic respiratory inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Airway epithelial cells are the primary site of rhinovirus replication and responsible for initiating the host immune response to infection. Numerous studies have reported that the anti-viral innate immune response in asthma is deficient leading to the conclusion that epithelial innate immunity is a key determinant of disease severity during a rhinovirus induced exacerbation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
120 Samples
Download data: CSV
Series
Accession:
GSE146532
ID:
200146532
11.

Rhinovirus Infection Induces a Differential Gene Expression Pattern in Pulmonary Epithelial Cells

(Submitter supplied) We aimed to investigate whether HRV infection induces a specific gene expression pattern in airway epithelial cells. The study suggests the underlying molecular regulatory networks genes which might be involved in pathogenicity of the HRV-B and potential targets for further validations and development of effective treatment.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15207
24 Samples
Download data: CEL, CHP
Series
Accession:
GSE87463
ID:
200087463
12.

RNA sequencing of primary bronchial airway epithelial cells from young children with and without CF, including those with and without rhinovirus infection in vitro

(Submitter supplied) Early life viral infections are responsible for pulmonary exacerbations that can contribute to disease progression in young children with CF. The most common respiratory viruses detected in the CF airway are human rhinoviruses (RV) and susceptibility to infection has been attributed to dysregulated airway epithelial responses, although evidence has been conflicting. Here, we exposed airway epithelial cells from children with and without CF to RV in vitro. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
24 Samples
Download data: CSV
Series
Accession:
GSE138167
ID:
200138167
13.

HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL

(Submitter supplied) Objective: Cigarette smoking ameliorates ulcerative colitis (UC) and aggravates Crohn’s disease (CD). Cigarette smoke suppresses inflammation-induced apoptosis in intestinal epithelial cells (DLD-1), which may explain its protective effect in UC. Here, we performed transcriptome profiling of cigarette smoke extract (CSE)-exposed DLD-1 and Jurkat cells (T-lymphocytes) and related this to UC susceptibility genes with protective functions in the intestinal epithelium. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
36 Samples
Download data: TXT
Series
Accession:
GSE72163
ID:
200072163
14.

Differential RNASeq of human bronchial and nasal epithelial cells stimulated with RIG-I ligand SLR14

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
8 Samples
Download data
Series
Accession:
GSE117884
ID:
200117884
15.

Differential RNASeq of human nasal epithelial cells stimulated with RIG-I ligand SLR14

(Submitter supplied) The purpose of this study was to assess transcriptome changes in primary human airway epithelial cells following stimulation with RIG-I ligand.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
4 Samples
Download data: TXT
Series
Accession:
GSE107898
ID:
200107898
16.

Differential RNASeq of human bronchial epithelial cells stimulated with RIG-I ligand SLR14

(Submitter supplied) The purpose of this study was to assess transcriptome changes in primary human airway epithelial cells following stimulation with RIG-I ligand.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
4 Samples
Download data: TXT
Series
Accession:
GSE107897
ID:
200107897
17.

Major and Minor Group Human Rhinovirus Response in Human Macrophages

(Submitter supplied) Major- and minor-group rhinoviruses enter their host by binding to the cell surface molecules ICAM-1 and LDL-R, respectively, which are present on both macrophages and epithelial cells. Although epithelial cells are the primary site of productive HRV infection, previous studies have implicated macrophages in establishing the cytokine dysregulation that occurs during rhinovirus-induced asthma exacerbations. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15433
3 Samples
Download data: TXT
Series
Accession:
GSE55271
ID:
200055271
18.

The Impact of Acute Exposure to Cigarette Smoke on Airway Gene Expression

(Submitter supplied) BACKGROUND: We have previously reported gene expression changes in the bronchial airway epithelium of active chronic smokers. In this study, we investigate the effects of Acute Smoke Exposure (ASE) from cigarettes on airway epithelial gene expression. METHODS: Bronchial airway epithelial cell brushings were collected via fiberoptic bronchoscopy from 63 individuals without recent exposure to cigarette smoke (> 2 days), at baseline and at 24 hours after smoking three cigarettes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17244
126 Samples
Download data: CEL
Series
Accession:
GSE97010
ID:
200097010
19.

Effects of cigarette smoke on the human airway epithelial cell transcriptome

(Submitter supplied) A number of studies have shown that cigarette smoking produces a field defect, such that genetic mutations induced by smoking occur throughout the lung and its intra and extra-pulmonary airways. Based on this concept, we have begun this study, which has as its goal the definition of the normal airway transcriptome, an analysis of how that transcriptome is affected by cigarette smoke, and to explore the reversibility of altered gene expression when smoking has been discontinued. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS534
Platform:
GPL96
75 Samples
Download data: CEL
Series
Accession:
GSE994
ID:
200000994
20.
Full record GDS534

Smoking-induced changes in airway transcriptome

Analysis of cigarette smoking-induced changes in bronchial epithelia, and reversibility of effects when smoking is discontinued. May provide insight to molecular events leading to chronic obstructive pulmonary disease (COPD) and lung cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 other sets
Platform:
GPL96
Series:
GSE994
75 Samples
Download data: CEL
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