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Links from GEO DataSets

Items: 20

1.
Full record GDS4856

Transcription factor Yin Yang 1 deficiency effect on the skeletal muscle

Analysis of the soleus muscles of transcription factor Yin Yang 1 (YY1) deficient animals. Many nuclear genes encoding mitochondrial proteins contain binding sites for YY1 in their proximal promoters. Results provide insight into the role of YY1 in mitochondrial function.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE39009
7 Samples
Download data: CEL
2.

Expression data from mouse skeletal muscle

(Submitter supplied) We generated skeletal muscle-specific knockout mice lacking the transcription factor Yin Yang 1 (YY1) and analyzed expression patterns in the skeletal muscle these mice. We used microarrays to detail the global programme of gene expression regulated by YY1.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4856
Platform:
GPL8321
7 Samples
Download data: CEL
Series
Accession:
GSE39009
ID:
200039009
3.

mTOR pathway controls mitochondrial gene expression and respiration through the YY1/PGC-1alpha transcriptional complex

(Submitter supplied) Mitochondrial oxidative function is tightly controlled to maintain energy homeostasis in response to nutrient and hormonal signals. An important cellular component in the energy sensing response is the target of rapamycin (TOR) kinase pathway; however whether and how mTOR controls mitochondrial oxidative activity is unknown. Here, we show that mTOR kinase activity stimulates mitochondrial gene expression and oxidative function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE5332
ID:
200005332
4.

YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming during adult muscle stem cell activation

(Submitter supplied) Skeletal muscle satellite cells (SCs) are adult muscle stem cells responsible for muscle regeneration after acute or chronic injuries. The lineage progression of quiescent satellite cells toward activation, proliferation and differentiation during the regeneration is orchestrated by cascades of transcription factors (TFs). Here we elucidate the functional role of a ubiquitously expressed TF, Yin Yang1 (YY1) in muscle regeneration. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL15103 GPL13112
6 Samples
Download data: BED, TXT
Series
Accession:
GSE108249
ID:
200108249
5.

YY1 Control of Mitochondrial-Related Genes does not Account for Regulation of Immunoglobulin Class Switch Recombination

(Submitter supplied) Immunoglobulin class switch recombination (CSR) occurs in activated B cells with increased mitochondrial mass and membrane potential. Transcription factor YY1 is critical for CSR and for formation of the DNA loops involved in this process. We therefore sought to determine if YY1 knockout impacts mitochondrial gene expression and mitochondrial function in murine splenic B cells, providing a potential mechanism for regulating CSR. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21626
9 Samples
Download data: BED, TXT
Series
Accession:
GSE145161
ID:
200145161
6.

RNA-Seq analysis of murine splenic B cells with deletion of YY1

(Submitter supplied) X chromosome inactivation (XCI) in female lymphocytes is uniquely regulated, as the inactive X (Xi) chromosome lacks localized Xist RNA and heterochromatin modifications. Epigenetic profiling reveals that Xist RNA is lost from the Xi at the pro-B cell stage and that additional heterochromatic modifications are gradually lost during B cell development. Activation of mature B cells restores Xist RNA and heterochromatin to the Xi in a dynamic two-step process that differs in timing and pattern, depending on the method of B cell stimulation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21626
18 Samples
Download data: TXT
Series
Accession:
GSE104097
ID:
200104097
7.

Brown fat-specific YY1 deficiency effect on subcutaneous white adipose tissue

(Submitter supplied) Analysis of visceral white adipose tissue (EWAT) from Yin Yang 1 adipose-specific knockout mice exposed to cold (4ºC) for 4 days.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
6 Samples
Download data: CEL
Series
Accession:
GSE70562
ID:
200070562
8.

Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
18 Samples
Download data: CEL
Series
Accession:
GSE68443
ID:
200068443
9.

Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [BAT]

(Submitter supplied) Analysis of brown adipose tissue from Yin Yang 1 (YY1) brown fat specific knockout mice fed a high fat diet for 3 months. YY1 deficiency in brown adipose tissue leads to strong thermogenic deficiency. The goal was to identify the genes controlled by YY1 responsible of brown fat defective function.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
6 Samples
Download data: CEL
Series
Accession:
GSE68429
ID:
200068429
10.

Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [IWAT]

(Submitter supplied) Analysis of subcutaneous adipose tissue (IWAT) from Yin Yang 1 brown fat specific knockout mice fed a high fat diet for 2 weeks. The goal was to identify a gene signature of IWAT browning in YY1 mutant mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
6 Samples
Download data: CEL
Series
Accession:
GSE68382
ID:
200068382
11.

Yin Yang 1 interacts with bromodomain-containing coactivators to promote tumorigenesis of advanced prostate cancer

(Submitter supplied) Castration-resistant prostate cancer (CRPC) is a terminal disease and the molecular underpinnings of CRPC development need to be better understood in order to improve its treatments. Here, we report that a transcription factor Yin Yang 1 (YY1) is significantly overexpressed during prostate cancer progression. Functional and cistrome studies of YY1 uncover its roles in promoting prostate oncogenesis in vitro and in vivo, as well as sustaining tumor metabolism including the Warburg effect and mitochondria respiration. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21697
4 Samples
Download data: BW
Series
Accession:
GSE164719
ID:
200164719
12.

A regulatory axis of YY1-PFKP promotes aggressive prostate tumorigenesis via potentiating tumor cell metabolism

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21697 GPL24676
14 Samples
Download data: BW
Series
Accession:
GSE153640
ID:
200153640
13.

A regulatory axis of YY1-PFKP promotes aggressive prostate tumorigenesis via potentiating tumor cell metabolism [ChIP-seq]

(Submitter supplied) Yin Yang 1 (YY1) acts as a transcription factor crucially involved in cell proliferation, differentiation and survival. We here report that YY1, through gene expression regulation, plays an important role in prostate tumorigenesis, notably in castration-resistant prostate cancer (CRPC) models. Specifically, we found that YY1 displays a significantly elevated level among primary samples from prostate cancer patients, relative to normal. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21697
2 Samples
Download data: BW
Series
Accession:
GSE153639
ID:
200153639
14.

A regulatory axis of YY1-PFKP promotes aggressive prostate tumorigenesis via potentiating tumor cell metabolism [RNA-seq]

(Submitter supplied) Yin Yang 1 (YY1) acts as a transcription factor crucially involved in cell proliferation, differentiation and survival. We here report that YY1, through gene expression regulation, plays an important role in prostate tumorigenesis, notably in castration-resistant prostate cancer (CRPC) models. Specifically, we found that YY1 displays a significantly elevated level among primary samples from prostate cancer patients, relative to normal. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
8 Samples
Download data: TXT
Series
Accession:
GSE153518
ID:
200153518
15.

Canonical and non-canonical regulatory roles of androgen receptor variant 7 in prostate cancer

(Submitter supplied) The androgen receptor splice variant 7 (AR-V7) lacks the ligand-binding domain; is detected with increased frequency in advanced prostate cancer and is postulated to be one crucial mechanism for disease progression and therapeutic resistance to androgen deprivation in castration–resistant prostate cancer (CRPC). Targeting AR-V7 or unique downstream targets could provide novel therapeutic approaches for CRPC. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16791 GPL11154
36 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE94013
ID:
200094013
16.

A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis

(Submitter supplied) During late gestation, structures called villi extend into the intestinal lumen to dramatically increase the surface area of the intestinal epithelium, preparing the gut for the neonatal diet. Incomplete development of the intestine is the most common gastrointestinal complication in neonates, but the causes are unclear. We provide evidence that Yin-Yang1 (Yy1) is critical for intestinal villus development. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL, TXT
Series
Accession:
GSE85602
ID:
200085602
17.

Effects of a 8-week training on human skeletal muscle

(Submitter supplied) Context: Exercise training is a plausible model for identification of molecular mechanisms that cause metabolic-related changes in human skeletal muscle. Objective: The goal was to explore the molecular basis of the adaptation of skeletal muscle to exercise training. Design and Intervention: Obese male subjects were subjected to an individualized supervised training program targeted in order to optimize lipid oxidation during 8 weeks. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16022
16 Samples
Download data: GPR
Series
Accession:
GSE40551
ID:
200040551
18.

Muscle-specific gene expression changes in normal and high-fat diet in spinal and bulbar muscular atrophy (SBMA)

(Submitter supplied) The pattern of gene expression changes were analyzed in the skeletal muscle of knock-in mouse models of SBMA fed either a normal chow diet (NCD) or a high-fat diet (HFD).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
19 Samples
Download data: TXT
Series
Accession:
GSE68441
ID:
200068441
19.

Skeletal muscle PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction.

(Submitter supplied) Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation and reactive oxygen species scavenging in skeletal muscle and other tissues, and these processes are thought to be critical to the benefits of CR. PGC-1a is a transcriptional coactivator that regulates mitochondrial function and is induced by CR. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
26 Samples
Download data: CEL
Series
Accession:
GSE34773
ID:
200034773
20.

The effects of Mkp-1 knockout and systemic E. coli infection on the transcriptome of the liver

(Submitter supplied) Previously, I have found that Mkp-1 knockout exacerbates inflammation, perturbs lipid metabolism, increases organ damage, mortality, and bacterial burdens. To understand the role of Mkp-1 in the regulation of host defense, we performed RNA-seq analysis using total RNA isolated from livers of uninfected and E. coli-infected wildtype and Mkp-1 knockout mice. Specifically, Mkp-1 wildtype and knockout (both on the C57/129 background) mice were infected with E. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
16 Samples
Download data: TXT
Series
Accession:
GSE122741
ID:
200122741
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