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Links from GEO DataSets

Items: 7

1.
Full record GDS4860

All-trans retinoic acid (ATRA) vitamin A and 1,25-dihydroxyvitamin D3 (1,25D3) vitamin D stimulated peripheral blood monocytes

Analysis of monocytes stimulated with biologically active forms of vitamin A and vitamin D. Vitamin A plays a role in host defense against Mycobacterium tuberculosis. Results provide insight into molecular mechanisms underlying the antimicrobial activities for vitamin A and vitamin D in monocytes.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent, 4 individual sets
Platform:
GPL570
Series:
GSE46268
12 Samples
Download data: CEL, CHP
2.

Gene expression profile of human monocytes stimulated with all-trans retinoic acid (ATRA) or 1,25a-dihydroxyvitamin D3 (1,25D3)

(Submitter supplied) A role for vitamin A in host defense against Mycobacterium tuberculosis has been suggested through epidemiological and in vitro studies; however, the antimicrobial mechanism is unclear. Here, we demonstrate that vitamin A mediates host defense through regulation of cellular cholesterol content. Comparison of monocytes stimulated with all-trans retinoic acid (ATRA) or 1,25-dihydroxyvitamin D3, the biologically active forms of vitamin A and vitamin D respectively, indicates that ATRA and 1,25D3 induce mechanistically distinct antimicrobial activities. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4860
Platform:
GPL570
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE46268
ID:
200046268
3.

Microarray analysis adherent peripheral blood mononuclear cells stimulated with IL-10, IL-15, and IL-4

(Submitter supplied) Tuberculosis remains a major cause of death from an infectious disease worldwide, yet only 10% of people infected with Mycobacterium tuberculosis develop disease. Defining both necessary and sufficient immunologic determinants of protection remains a great scientific challenge. Analysis of peripheral blood gene expression profiles of active tuberculosis patients has identified correlates of risk for disease or pathogenesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
32 Samples
Download data: CEL
Series
Accession:
GSE59184
ID:
200059184
4.

Vitamin D treatment of M.tb. infected macrophages

(Submitter supplied) As macrophages are the primary site of Mtb infection and are sites of vitamin D signaling, we have used these cells to understand the molecular mechanisms underlying modulation of the immune response by the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D). Microarrays were used to measure the changes in gene expression induced by 1,25D treatment of H37Rv-infected THP-1 cells
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4781
Platform:
GPL6244
12 Samples
Download data: CEL, XLSX
Series
Accession:
GSE52819
ID:
200052819
5.
Full record GDS4781

Mycobacterium tuberculosis H37Rv-infected macrophages response to vitamin D

Analysis of Mtb H37Rv-infected THP-1 macrophages treated with the hormonal form of vitamin D (1,25D). Macrophages are the primary site of Mtb infection and are sites of 1,25D signaling. Results provide insight into the molecular basis of the 1,25D-enhanced macrophage response to Mtb infection.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 infection sets
Platform:
GPL6244
Series:
GSE52819
12 Samples
Download data: CEL
6.

Transcriptomics of vitamin D treatment effects in Mycobacterium tuberculosis-infected THP-1 cells

(Submitter supplied) Previous reports have shown low vitamin D serum levels and polymorphisms in the vitamin D receptor (VDR) to be associated with increased risk for TB. Given that 1α,25-dihydroxyvitamin D3 has a role in lipid metabolism control, we tested whether the link between 1α,25-dihydroxyvitamin D3 and tuberculosis involves macrophage lipid metabolism. Since formation of lipid droplets (LD) is a hallmark of lipid dysregulation in M. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
14 Samples
Download data: CEL
Series
Accession:
GSE57028
ID:
200057028
7.

Tubercolosis and healthy infected patients PBMC_TB_vs_Pool_LTBI

(Submitter supplied) Comparison of PBMC tuberculosis patients and healthy infected control donors via an reference RNA pool from non-infected controls Keywords: Case control study
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4475
36 Samples
Download data: XML
Series
Accession:
GSE6112
ID:
200006112
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