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Links from GEO DataSets

Items: 6

1.
Full record GDS4869

Imatinib mesylate effect on bone marrow hematopoietic cells of chronic myeloid leukemia patients

Analysis of bone marrow hematopoietic cells in chronic myeloid leukemia (CML) patients one month after imatinib mesylate (IM) therapy. CML is caused by expression of the BCR/ABL fusion oncogene. Results provide insight into the molecular consequences of IM blockade of oncoprotein Bcr-Abl in CML.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 10 age, 10 gender, 10 individual, 3 protocol sets
Platform:
GPL570
Series:
GSE33075
27 Samples
Download data: CEL
DataSet
Accession:
GDS4869
ID:
4869
2.

Imatinib therapy of chronic myeloid leukemia restores the expression levels of key genes for DNA damage and cell cycle progression

(Submitter supplied) Background: Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. It is well known that CML cells are genetically unstable. However, the mechanisms by which these cells acquire genetic alterations are poorly understood. Imatinib mesylate (IM) is the standard therapy for newly diagnosed CML patients. IM targets the oncogenic kinase activity of BCR-ABL. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4869
Platform:
GPL570
27 Samples
Download data: CEL
Series
Accession:
GSE33075
ID:
200033075
3.

Imatinib effects on CD34+ cells

(Submitter supplied) purified CD34+ cells from bone marrow of imatinib-treated patients were compared to those of healthy donors Keywords = CML Keywords = CD34+ cells Keywords = imatinib Keywords: ordered
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS838
Platform:
GPL201
14 Samples
Download data: CEL
Series
Accession:
GSE1418
ID:
200001418
4.
Full record GDS838

Imatinib effects on chronic myelogenous leukemia CD34+ cells

Comparison of purified bone marrow CD34+ cells from imatinib-treated chronic myelogenous leukemia (CML) patients and healthy donors.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL201
Series:
GSE1418
14 Samples
Download data: CEL
DataSet
Accession:
GDS838
ID:
838
5.

Gene expression profiling of CD34/CD38 sorted CML cells

(Submitter supplied) BACKGROUND: BCR-ABL1+ chronic myeloid leukemia (CML) is characterized by abnormal production of leukemic stem (LSC) and progenitor cells and their spread from the bone marrow into the blood resulting in extramedullary myeloproliferation. So far, little is known about specific markers and functions of LSC in CML. METHODS: We examined the phenotype and function of CD34+/CD38─/Lin─ CML LSC by a multi-parameter screen approach employing antibody-phenotyping, mRNA expression profiling, and functional studies, including LSC repopulation experiments in irradiated NOD-SCID-IL-2Rgamma-/- (NSG) mice, followed by marker-validation using diverse control-cohorts and follow-up samples of CML patients treated with imatinib. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15207
10 Samples
Download data: CEL
Series
Accession:
GSE40721
ID:
200040721
6.

Gene expression changes associated with progression and response in chronic myeloid leukemia

(Submitter supplied) Chronic myeloid leukemia (CML) is a hematopoetic stem cell disease with distinct biological and clinical features. The biological foundation of the stereotypical progression from chronic phase through accelerated phase to blast crisis is poorly understood. We used DNA microarrays to compare gene expression in 91 cases of CML in chronic (42 cases), accelerated (17 cases), and blast phases (32 cases). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2029
119 Samples
Download data: XLS
Series
Accession:
GSE4170
ID:
200004170
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